Exparel (Bupivacaine Liposome Injectable Suspension) for Distal Upper Extremity Blocks in Orthopedic Surgery

04262013

The purpose of this study is to compare Exparel, a new, long-lasting numbing medication and a shorter-acting nerve block to a traditional single-shot nerve block in patients having hand, wrist or finger surgery.

2014-02-01

2016-03-01

2016-03-01

Terminated

Early phase I

37

Inclusion Criteria: * patients 18 years or older having hand, wrist, or finger surgery * ability to understand and provide informed consent * American Society of Anesthesiologists status I-III * presence of a responsible adult caregiver for 48-72 hours after surgery Exclusion Criteria: * patient refusal or inability to provide informed consent * true allergy, not sensitivity to local anesthetics, midazolam, fentanyl, hydromorphone, propofol * pregnancy * hepatic or renal failure * evidence of infection at or near the proposed needle insertion site * any sensorimotor deficit of the upper extremity * BMI greater than or equal to 35 * uncontrolled or severe pulmonary disease * anticoagulant use (not aspirin or non-steroidal anti-inflammatories) * chronic pain patients

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 37, 'type': 'ACTUAL'}}

2024-05-21