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Clinical trial

Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based Stones Among Patients With Renal Calcular Disease in Mansoura Urology and Nephrology Center

ID
Name
MD.21.02.426
Description
Evaluation of Prevalence, Molecular and Genetic Backgrounds of Calcium-Based stones among Patients with Renal Calcular Disease in Mansoura Urology and Nephrology Center
Trial arms
Trial start
2021-03-21
Estimated PCD
2023-09-21
Trial end
2024-01-19
Status
Completed
Treatment
percutaneous nephrlolithotomy
Endoscopic removal of renal stones
VDR gene, CASR gene
checking possible mutations of VDR and CASR genes
Size
84
Primary endpoint
prevalence of Ca-based renal stones
two years
Genetic background of Ca based renal stones
two years
Eligibility criteria
Inclusion Criteria: * All patients with unilateral or bilateral renal stones (de novo or recurrent) who were candidates for endoscopic or surgical intervention were included. Metabolic workup was done for selected patients with radio-opaque stones, while genetic testing was done for those with dominant Ca composition proven by postoperative stone analysis. Thirty healthy individuals with no urologic abnormalities were involved as control cases. Patients with renal calculi for whom metabolic and genetic testing were performed are designated "α" cases. Exclusion Criteria: * For metabolic and genetic testing, patients with a well-known lesion precipitating stone disease were excluded e.g. ureteric stricture, ureteropelvic or ureterovesical junction obstruction, urinary diversion, history of ureterovesical re-implantation as well as patients with non-Ca stones by post-operative stone analysis
Protocol
{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'enrollmentInfo': {'count': 84, 'type': 'ACTUAL'}}
Updated at
2024-06-10

1 organization

1 product

1 indication

Organization
Mansoura University
Product
VDR
Indication
Kidney Stones