Clinical trial
Contribution of PET/CT With Gallium 68 Citrate (68Ga-PET/CT) for the Diagnosis of Prosthetic Valve Infective Endocarditis
Name
CHUBX 2020/49
Description
CiGal-EI-TEP is an exploratory study that aim to assess the diagnostic performance of 68Ga Positron emission tomography (PET) / Computed Tomography (CT) for the diagnosis of prosthetic valve infective endocarditis in comparison with the final diagnosis established according to the ESC 2023 criteria, after 3 months of follow-up, by a panel of experts.
Trial arms
Trial start
2024-02-01
Estimated PCD
2026-02-01
Trial end
2026-02-01
Status
Not yet recruiting
Phase
Early phase I
Treatment
68Ga-citrate PET/CT
PET/CT Imaging with 68Ga-citrate PET/CT injection
Arms:
68Ga-citrate PET/CT
Size
40
Primary endpoint
Sensitivity of 68Ga-PET/CT for the diagnosis of prosthetic valve infective endocarditis in patients suspected of infective endocarditis on prosthetic valve
3 months after baseline (Day 0)
Eligibility criteria
Inclusion Criteria:
* adult patient (over 18 years old);
* patient with a prosthetic heart valve;
* patient suspected of infective endocarditis (on clinical and/or microbiological and/or imaging data);
* patient whose history is discussed in the multidisciplinary meeting dedicated to endocarditis;
* patient beneficiary of a social security scheme;
* free, informed and written consent signed by the participant and the investigator.
Exclusion Criteria:
* pregnant or breastfeeding women;
* women of childbearing potential not using effective contraception;
* patients referred to in articles L.1121-5 to L.1121-8 (persons deprived of liberty by judicial or administrative decision, minors, adults subject to a legal protection measure or unable to express their consent);
* subject in a period of relative exclusion due to another protocol;
* known contraindication to PET/CT with injection of radiotracers (hypersensitivity to radiopharmaceuticals and/or excipients).
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'DIAGNOSTIC', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 40, 'type': 'ESTIMATED'}}
Updated at
2024-01-12
1 organization
1 product
1 indication
Organization
University Hospital BordeauxProduct
68Ga-citrateIndication
Endocarditis