Clinical trial
ESO-Shanghai9
Name
ESO-Shanghai9
Description
The purpose of this study is to evaluate safety and 2-year local control rate for extensive clinical target volumes in postoperative radiotherapy concurrent with chemotherapy for esophageal squamous cell carcinoma.
Trial arms
Trial start
2016-09-01
Estimated PCD
2021-07-01
Trial end
2023-07-01
Status
Completed
Phase
Early phase I
Treatment
Paclitaxel
paclitaxel 50mg/m2/d, ivgtt over 3 hours, d1, qw\*5
Arms:
Chemo-radiation group
Carboplatin
carboplatin AUC=2, ivgtt, d1, qw\*5
Arms:
Chemo-radiation group
Radiotherapy
1.8Gy/d, d1-5/week, 25Fx
Arms:
Chemo-radiation group
Size
70
Primary endpoint
Local control rate
2 years
Eligibility criteria
Inclusion Criteria:
* Joined the study voluntarily and signed informed consent form;
* Age 18-75;
* ECOG 0-2;
* Esophageal squamous cell carcinoma, radical surgery ≤ 3 months, R0 resection;
* The operative incision healed well;
* T3-4N0M0, T1-4N1-3M0 (according to AJCC2009);
* No radiotherapy, chemotherapy or other treatments pre (post) surgery;
* PS ECOG 0-2;
* Life expectancy of more than 3 months;
* Hemoglobin (Hb) ≥ 9 g/dL • WBC ≥ 3 x 109/L, Neutrophils (ANC ) ≥ 1.5 x 109/L • platelet count (Pt) ≥ 100 x 109/L • Hepatic function: ALAT and ASAT \< 2.5 x ULN, TBIL\< 1.5 x ULN • Renal function: creatinine \< 1.5 x ULN
* No immuno-deficiency;
* Use of an effective contraceptive for adults to prevent pregnancy.
Exclusion Criteria:
* Complete esophageal obstruction after surgery, Esophageal perforation, Haematemesis;
* Other malignant tumors, except for skin basal cell carcinoma, or cervical carcinoma in situ, who survived with no evidence disease for over 3 years;
* Participation in other interventional clinical trials within 30 days;
* Pregnant or breast-feeding women or people during the birth-period who refused to take contraceptives;
* Drug addiction, Alcoholism or AIDS;
* Uncontrolled seizures or psychiatric diseases, loss of control over their own behavior;
* Unsuitable to be enrolled in the trial in the opinion of the investigators.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NA', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 70, 'type': 'ACTUAL'}}
Updated at
2023-12-22
1 organization
1 product
1 drug
1 indication
Organization
Fudan UniversityDrug
TiragolumabIndication
Esophageal squamous cell carcinomaProduct
Carboplatin