Clinical trial
Methadone-Maintained Smokers Switching to E-Cigarettes
Name
1702236
Description
Participants in this randomized clinical trial will be methadone-maintained smokers interested in switching to electronic cigarettes (ECs). There will be a total of 7 study visits over the course of 6 weeks; each visit includes psychometric assessment and biomarker measurements. After completion of the baseline visit, participants will be randomized to either: 1) 6 weeks of EC use (JUUL 5% nicotine pods) or 2) 6 weeks of nicotine replacement therapy (NRT) in the form of nicotine lozenges. EC and NRT use will begin the day after the baseline assessment.
Trial arms
Trial start
2022-03-31
Estimated PCD
2024-06-30
Trial end
2024-06-30
Status
Recruiting
Phase
Early phase I
Treatment
Electronic Cigarette
Electronic Cigarettes are provided to replace tobacco cigarettes
Arms:
Electronic Cigarettes
Nicotine Lozenge
Nicotine Lozenges are provided to replace tobacco cigarettes
Arms:
Nicotine Lozenges
Size
240
Primary endpoint
Nicotine Exposure
6 weeks
FVC Lung Functioning
6 weeks
FEV1 Lung Functioning
6 weeks
FEV1/FVC Ratio Lung Functioning
6 weeks
Smoking Behavior and Experiences
6 weeks
Nicotine Exposure for Complete Switchers
6 weeks
FVC Lung Functioning for Complete Switchers
6 weeks
FEV1 Lung Functioning for Complete Switchers
6 weeks
FEV1/FVC Ratio Lung Functioning for Complete Switchers
6 weeks
Smoking Behavior and Experiences for Complete Switchers
6 weeks
Eligibility criteria
Inclusion Criteria:
* moderate to heavy cigarette smokers (10 cigarettes/day for \> 1 yr; breath CO \> 10 ppm)
* have been receiving methadone for at least three months
* attend at least weekly to receive methadone dose
* speak English
* have a telephone or access to a telephone
* are available over the next 6 weeks
* are interested in switching to either electronic cigarettes or nicotine replacement therapy
Exclusion Criteria:
* use of ECs on \> 2 of the past 30 days
* currently use medications that may reduce smoking (e.g., bupropion, varenicline, NRT)
* have unstable psychiatric conditions
* have near-daily or daily use of marijuana
* are pregnant
* had a cardiovascular event in the last month
* daily medication for asthma or COPD
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 240, 'type': 'ESTIMATED'}}
Updated at
2023-10-10
1 organization
2 products
2 indications
Organization
Butler HospitalProduct
Electronic CigaretteIndication
Nicotine DependenceIndication
VapingProduct
Nicotine