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Clinical trial

Comparative Examination of the Postoperative Effects of Low-laser Treatment and Platelet-rich Fibrin Applications After Mandibular Impacted Wisdom Teeth Extraction

ID
Name
YDU/2024/120-1808
Description
The aim of this study was investigate the comparison of postoperative effects of low laser treatment and platelet-rich fibrin application on mandibular impacted third molar tooth extraction. The study included a total of 60 patients with impacted mandibular third molar. Patients were evaluated in 4 randomly separated groups. In group 1, PRF was applied to the tooth socket. In group 2, PRF was applied to the tooth socket combined with Low Laser Treatment extraorally to the extraction area for three days within surgery day In group 3, Low Laser Treatment was applied to the extraorally to the extraction area for three days within surgery day. In group 4 (control group), tradional osteomy was made. The outcome variables were pain, swelling, the number of analgesics taken, and trismus. These variables were also assessed based on first, second, third, and seventh days following the operation. All of the 4 groups patients were prescribed an 875/125 mg amoxicillin/clavulanic acid tablet twice daily for five days.
Trial arms
Trial start
2024-01-02
Estimated PCD
2024-02-06
Trial end
2024-02-07
Status
Completed
Treatment
Diagnoses
All of the patients withstand a radiological examination, including panoramic radiography, and all were handled by the same surgeon and assistant.
Arms:
Control group., Group 1, Group 2, Group 3
traditional osteotomies
In all groups the flap incision was triangular in shape which avoids muscle involvement (Archer flap).
Arms:
Control group., Group 1, Group 2, Group 3
platelet rich fibrin
Platelet rich fibrin (PRF), is an example and popular procedure for accelerate healing of soft and hard tissue because of the presence of various growth factors.a blood sample was taken without anticoagulant in 10 mL glass-coated plastic tubes that were immediately centrifuged (Elektro-mag M415P) at 3,000 rpm for 10 min (approximately 400 g) (13). The platelet-poor plasma that accumulated at the top of the tubes was discarded.PRF was dissected approximately 2 mm below its contact point with the red corpuscles situated beneath, to include any remaining platelets that may have localized below the junction between the PRF and red corpuscles.
Arms:
Group 1, Group 2
Antibiotics, Penicillin
Antibiotics are prescribed for the patients.
Arms:
Control group., Group 1, Group 2, Group 3
low laser therapy, bicure laser
There are studies in the literature that low-energy lasers have positive effects on the biological and biochemical processes of wound healing. Acceleration of local circulation, increase in cell proliferation and collagen synthesis are among the various effects of laser application. B Cure Dental Pro Laser application will be applied to the patient for the first 3 days. Low dose laser application will be applied to the angulus area, covering the surgical area for 8 minutes. Before this laser procedure, the patient will be asked to fill out a pain scale. This pain scale and the number of analgesics used will be monitored for 3 days.
Arms:
Group 2, Group 3
Analgesic
Analgesics are prescribed for the patients.
Arms:
Control group., Group 1, Group 2, Group 3
Size
60
Primary endpoint
Visual analogue scale (VAS)
Day 1
Visual analogue scale (VAS)
Day 2
Visual analogue scale (VAS)
Day 3
Visual analogue scale (VAS)
Day 7
Trismus
Day 1
Trismus
Day 2
Trismus
Day 3
Trismus
Day 7
Swelling
Day 1
Swelling
Day 2
Swelling
Day 3
Swelling
Day 7
Eligibility criteria
Inclusion Criteria: * The patient had no systemic diseases, no taken opioids for a long period, no current infections or acute pericoronitis, no smoke or drink alcohol, no pregnancy, the absence of allergy to penicillin and presence of penicillin allergy. Exclusion Criteria: * pericoronitis, no inflammation
Protocol
{'studyType': 'OBSERVATIONAL', 'patientRegistry': False, 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'RETROSPECTIVE'}, 'enrollmentInfo': {'count': 60, 'type': 'ACTUAL'}}
Updated at
2024-02-16

1 organization

3 products

1 indication

Organization
Beste Erismen
Product
Platelet Rich Fibrin
Indication
Impacted Third Molar
Product
Antibiotics, Penicillin
Product
Analgesic