Clinical trial
Impact of Statin Therapy on Muscle Mitochondrial Function and Aerobic Capacity
Name
STUDY00140789
Description
The purpose of this study is to test how different doses of a statin, Lipitor, affect muscle health and function, and cardiovascular fitness.
Trial arms
Trial start
2018-02-22
Estimated PCD
2023-07-07
Trial end
2023-07-07
Status
Completed
Phase
Early phase I
Treatment
Lipitor 20Mg Tablet
20 mg/day pills.
Arms:
Low dose statin
Other names:
atorvastatin
Lipitor 80Mg Tablet
80 mg/day pills.
Arms:
High dose statin
Other names:
atorvastatin
Placebo Oral Tablet
Matching placebo pill.
Arms:
Placebo
Other names:
Placebo
Size
68
Primary endpoint
Difference in mitochondrial respiratory function
12 Months
Eligibility criteria
Inclusion Criteria:
* Body mass index (BMI) between 25-43
* Weight stable (no more than 5% change in body weight the previous 3 months)
* \>5% risk for a cardiovascular event in the next 10 years according to the 2013 American College of Cardiology/American Heart Association risk calculator and/or 2 out of 5 metabolic syndrome risk factors (Triglycerides ≥ 150 mg/dL; HDL ≤ 40 mg/dL; Glucose ≥ 100mg/dL; Waist Circumference ≥ 102cm for males, 88cm for females; Blood pressure: ≥ 130mmHg systolic and/or 85mmHg diastolic or being treated for hypertension) and/or LDL-Cholesterol \>120 mg/dl.
* Stable doses of medications for 90 days
* Willing to stop all Nonsteroidal Antiinflammatory Drugs (NSAIDs) and aspirin for 7 days prior to muscle biopsy
Exclusion Criteria:
* Smoking
* Previous use of statins
* Use of other medications or supplements that affect lipid profiles or body weight in the last 6 months (e.g., fibric acids, bile acid sequestrants, nicotinic acids, fish oil)
* Diagnosis of chronic diseases including CVD, other metabolic diseases (e.g., thyroid), current diagnosis and active treatment of cancer, HIV, or acquired immunodeficiency syndrome.
* Diagnosis of type 1 or type 2 diabetes at the time of screening (fasting blood glucose \>126mg/dL). If evidence of type 2 diabetes outcome measures is detected during the course of the study (fasting glucose \> 126 mg/dl or HbA1c \> 6.5%) we will notify the participant to contact their physician.
* History of abnormal bleeding problems
* Currently taking (within the last 10 days) anti-platelet medication (Plavix), Warfarin, and other anti-coagulants (eliquis, pradaxa, and xarelto) medications.
* \>2 fold upper normal limit (UNL) for alanine aminotransferase (ALT) or creatinine
* Women who are pregnant or breastfeeding
* Individuals with polymorphisms (SLCO1B1 and GATM) known to be associated with susceptibility for statin induced myopathies (tested at screening)
* Currently enrolled in another research study
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE4'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'PREVENTION', 'maskingInfo': {'masking': 'DOUBLE', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 68, 'type': 'ACTUAL'}}
Updated at
2023-12-08
1 organization
2 products
1 indication
Organization
University of Kansas Medical CenterProduct
LipitorIndication
Mitochondrial DiseasesProduct
Placebo