Indication
Cognitive Impairment
68 clinical trials
69 products
2 drugs
Clinical trial
Pilot Study of GLY-LOW Supplementation in Postmenopausal Women With ObesityStatus: Recruiting, Estimated PCD: 2024-07-27
Clinical trial
A First in Human Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Oral Doses of KYN-5356 in Adult, Healthy SubjectsStatus: Recruiting, Estimated PCD: 2024-07-01
Product
placeboClinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Assess the Efficacy and Safety of JNJ-63733657, an Anti-tau Monoclonal Antibody, in Participants With Early Alzheimer's DiseaseStatus: Active (not recruiting), Estimated PCD: 2025-03-07
Product
PlaceboProduct
JNJ-63733657Product
KYN-5356Product
MW151Clinical trial
Safety and Tolerability of MW151 Administered With Whole-brain Radiotherapy in Patients With Intracranial MetastasesStatus: Recruiting, Estimated PCD: 2025-08-31
Product
GLY-LOWProduct
Valerian-Hop ExtractClinical trial
Feasibility Study on the Use of Redormin® 500 (Ze 91019) on Day-time Cognition and Quality of Life in People With Occasional Sleep ProblemsStatus: Completed, Estimated PCD: 2023-12-20
Product
SAGE-718Clinical trial
A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effects of SAGE-718 in Parkinson's Disease Cognitive ImpairmentStatus: Completed, Estimated PCD: 2024-01-17
Product
MetaxaloneClinical trial
Assessment of the Effect of Metaxalone 640 mg (M640) on Truck Driving Ability and Cognition Compared to Other Skeletal Muscle Relaxants: A Prospective, Single-blind, Within-subject Pilot StudyStatus: Recruiting, Estimated PCD: 2025-04-15
Product
TizanidineClinical trial
An Open-Label Evaluation of the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's DiseaseStatus: Completed, Estimated PCD: 2021-09-21
Clinical trial
An Open-Label Investigation of the Effects of Sub-Perceptual Repeat Dosing of Psilocybin on the Behavioural and Cognitive Symptoms of Fragile X Syndrome in Adult PatientsStatus: , Estimated PCD: 2024-05-01
Product
PsilocybinProduct
ACI-35.030Clinical trial
A Phase Ib/IIa Multicenter, Double-Blind, Randomized, Placebo-Controlled Study to Evaluate the Safety, Tolerability and Immunogenicity of Different Doses, Regimens and Combinations of Tau Targeted Vaccines in Subjects With Early Alzheimer's DiseaseStatus: Completed, Estimated PCD: 2023-09-05
Clinical trial
A Multicentre Double-blind Placebo-controlled Randomized Study of Efficacy and Safety of Cytoflavin®, Intravenous Administration and Enteric-coated Tablets, Used in Elderly Patients for Prevention of Cognitive Decline After Major SurgeryStatus: Completed, Estimated PCD: 2019-04-11
Product
RL-007Clinical trial
An Adaptive, Randomized, Placebo-controlled, Double-blind Study to Evaluate the Safety and Efficacy of RL-007 in the Treatment of Cognitive Impairment Associated With Schizophrenia (CIAS)Status: Recruiting, Estimated PCD: 2024-07-15
Product
JACI-35.054Product
CytoflavinClinical trial
An Open-Label Evaluation of the Safety and Tolerability of SAGE-718 in Participants With Parkinson's Disease Mild Cognitive ImpairmentStatus: Completed, Estimated PCD: 2022-03-25
Product
VIX001Clinical trial
Phase 1 Study: Assessing VIX001 Safety, Efficacy, and Dosing in Post Acute COVID-19 Syndrome (PACS) Patients With Neurological Symptoms and Cognitive Impairment.Status: Not yet recruiting, Estimated PCD: 2025-04-01
Clinical trial
Lithium Treatment to Prevent Cognitive Impairment After Brain RadiotherapyStatus: Recruiting, Estimated PCD: 2030-08-31
Product
LithiumClinical trial
Building a Platform for Precision Anesthesia in the Geriatric Surgical PatientStatus: Recruiting, Estimated PCD: 2024-08-30
Product
Neurocognition InterventionsClinical trial
Effect of Pentoxifylline on Cognitive Impairment After Ischemic Stroke and Its Mechanism of Brain Electricity and Brain MetabolismStatus: Recruiting, Estimated PCD: 2024-10-31
Product
PentoxifyllineClinical trial
Phase I Dose-Escalating and Phase II Dose-Expansion Study of N-Acetyl-Cysteine (NAC) Administration to Ovarian Cancer Patients Receiving Platinum-Based Therapy (PBT) for the Mitigation of Chemotherapy-Related Cognitive Impairment (CRCI)Status: Not yet recruiting, Estimated PCD: 2025-12-01
Product
N-Acetyl-CysteineClinical trial
Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway (CARPE DIEM)Status: Completed, Estimated PCD: 2022-01-13
Drug
sirolimusClinical trial
Cognitive Decline and Underlying Mechanisms in Symptomatic Intracranial Atherosclerotic Stenosis Patients: A Multicenter Cohort StudyStatus: Recruiting, Estimated PCD: 2025-12-31
Product
AspirinClinical trial
The Effects of Some Antihyperglycemic Drugs on Cognitive Function and Risk of Depression of Diabetic PatientsStatus: Not yet recruiting, Estimated PCD: 2024-06-30
Product
ControlProduct
DPP-4 inhibitorProduct
DPP-4 inhibitor + metforminClinical trial
Large-Scale Randomized Clinical Trial Assessing Intensive Blood Pressure Control for Reduction of Major Cardiovascular Events in Patients With Diabetes Mellitus (OPTIMAL-DIABETES)Status: Active (not recruiting), Estimated PCD: 2025-12-31
Clinical trial
Cognitive Decline and Underlying Mechanisms in Asymptomatic Intracranial Artery Stenosis Patients: A Cohort StudyStatus: Recruiting, Estimated PCD: 2024-12-31
Clinical trial
Examining the Role of Tolerance on Dose-dependent Effects of Acute THC on Oculomotor and Cognitive PerformanceStatus: Not yet recruiting, Estimated PCD: 2025-08-01
Product
CannabisClinical trial
Cognitive Improvement After cARotid stEnting in HyperBaric Oxygen Therapy Trial (CARE-HBOT)Status: Not yet recruiting, Estimated PCD: 2025-12-31
Product
Standard medical treatmentClinical trial
Effect of Dexmedetomidine on Serum Tau-217 Protein as a Biomarker for Post-operative Cognitive Dysfunction in Elderly Patients.Status: Recruiting, Estimated PCD: 2025-03-01
Product
DexmedetomidineClinical trial
Stellate Ganglion Block in Cerebral Small Vessel Disease Patients With Dysphagia and Cognitive ImpairmentStatus: Completed, Estimated PCD: 2023-05-05
Product
Stellate ganglionClinical trial
Gulf War Illness Inflammation Reduction TrialStatus: Completed, Estimated PCD: 2023-10-19
Product
Modified-Release PrednisoneClinical trial
A Phase 3 Randomized Placebo Controlled Clinical Trial of Donepezil in Chemotherapy Exposed Breast Cancer Survivors With Cognitive ImpairmentStatus: Completed, Estimated PCD: 2022-07-29
Product
DonepezilClinical trial
Choline to Improve Malnutrition and Enhance CognitionStatus: Recruiting, Estimated PCD: 2026-03-01
Product
AmoxicillinClinical trial
Multimodal Assessment of Cognitive Impairment in Alzheimer PatientsStatus: Not yet recruiting, Estimated PCD: 2030-12-29
Product
Blood samplesClinical trial
Amyloid Deposition and Preexisting Vulnerable Carotid Plaque Features Predicting Cognitive Improvement After SurgeryStatus: Active (not recruiting), Estimated PCD: 2024-09-10
Product
Flutemetamol F 18 PETProduct
Fecal samplesClinical trial
The Safety and Efficacy of Fecal Microbiota Transplantation in Patients With Chronic Insomnia DisorderStatus: Active (not recruiting), Estimated PCD: 2025-06-01
Product
Fecal microbiotaClinical trial
Multimodal METformin and FINGER Lifestyle Intervention to Prevent Cognitive Impairment and Disability in Older Adults at Risk for Dementia: a Phase IIb Multi-national Randomised, Controlled TrialStatus: Recruiting, Estimated PCD: 2027-02-28
Product
FINGER 2.0Clinical trial
Maximizing trEatment of Neurological Dysfunction Using INtravenous Guanfacine StudyStatus: Active (not recruiting), Estimated PCD: 2024-03-30
Product
GuanfacineClinical trial
Study of Nasal Insulin to Fight Forgetfulness - Combination Intranasal Insulin and Empagliflozin TrialStatus: Recruiting, Estimated PCD: 2026-10-01
Product
Insulin (Humulin R U-100)Product
EmpagliflozinClinical trial
Characterization of Neuroimmune Dysfunction in Alcohol Use DisorderStatus: Completed, Estimated PCD: 2023-09-20
Product
MinocyclineProduct
Sugar pillClinical trial
Device Study for Intranasal Delivery of InsulinStatus: Active (not recruiting), Estimated PCD: 2025-08-01
Product
InsulinClinical trial
Research on Standardized Electronic Cognitive Training Technique in Early Stage of Senile Depression With Cognitive ImpairmentStatus: Recruiting, Estimated PCD: 2024-01-04
Clinical trial
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone TherapyStatus: Completed, Estimated PCD: 2023-10-04
Product
SomatropinClinical trial
11C-PIB PET Study in the Multi Ethnic Study of Atherosclerosis at Columbia UniversityStatus: , Estimated PCD: 2025-06-30
Product
11C-PIBClinical trial
PRagmatic EValuation of evENTs And Benefits of Lipid-lowering in oldEr Adults (PREVENTABLE)Status: Recruiting, Estimated PCD: 2026-06-30
Product
AtorvastatinClinical trial
A Randomized Controlled Trial to Assess the Effect of Intensive Blood Pressure Control on Major Cardiovascular Events in Stroke PatientsStatus: Active (not recruiting), Estimated PCD: 2025-12-01
Clinical trial
SNIFF Multi-Device Study 2 - Study of Nasal Insulin to Fight ForgetfulnessStatus: Active (not recruiting), Estimated PCD: 2025-10-01
Product
Humulin R U-100Clinical trial
MCLENA-1: A Phase II Clinical Trial for the Assessment of Safety, Tolerability, and Efficacy of Lenalidomide in Patients With Mild Cognitive Impairment Due to Alzheimer's DiseaseStatus: Recruiting, Estimated PCD: 2024-09-01
Product
LenalidomideClinical trial
Double Blind, Randomized, Placebo-Controlled Study of MitoQ as Adjunctive Treatment for Patients With Early-phase Schizophrenia-spectrum Disorder and Mitochondrial DysfunctionStatus: Not yet recruiting, Estimated PCD: 2027-01-31
Product
MitoQDrug
VarlilumabClinical trial
Bicarbonate Administration and Cognitive Function in Midlife and Older Adults With CKDStatus: Completed, Estimated PCD: 2023-08-30
Product
Sodium BicarbonateClinical trial
Impact of Obesity on Post-operative Cognitive Dysfunction: Role of Adipose TissueStatus: Recruiting, Estimated PCD: 2024-09-21
Product
Blood samplingProduct
White Adipose TissueClinical trial
Minocycline In Neurocognitive Outcomes - Sickle Cell DiseaseStatus: Not yet recruiting, Estimated PCD: 2025-12-01
Clinical trial
Phase II Study of Low-Dose Ibuprofen for Cognitive Problems in Patients With CancerStatus: Completed, Estimated PCD: 2022-03-30
Product
IbuprofenClinical trial
Clinical Evaluation on the Therapeutic Effect of Acupuncture Treatment for Alzheimer's Disease: Multicenter Randomized Controlled TrialStatus: Recruiting, Estimated PCD: 2024-12-30
Clinical trial
Donanemab Follow-On Study: Safety, Tolerability, And Efficacy in Symptomatic Alzheimer's Disease With Validation of Remote Neuropsychological AssessmentsStatus: Completed, Estimated PCD: 2024-02-27
Clinical trial
The Effect of Respiratory Muscle Performance on Cognitive Functions in Children With Epilepsy: Monitoring With Glymphatic System Activation and NeuropeptidesStatus: Recruiting, Estimated PCD: 2024-06-24
Product
Antiepileptic medicationClinical trial
Prospective Randomized Double Blind Placebo Controlled Study of Efficacy of the Therapy With BRAINMAX® Using Functional Magnetic Resonance Imaging (fMRI) for the Treatment of Patients With Post-COVID Asthenic SyndromeStatus: Completed, Estimated PCD: 2022-12-20
Clinical trial
Behavioral and Pharmacological Manipulation of Time Cell Activity in the Human Mesial Temporal LobeStatus: Recruiting, Estimated PCD: 2026-05-31
Product
ScopolamineClinical trial
Erythropoietin as an add-on Treatment for Cognitive Side-effects of Electroconvulsive TherapyStatus: Completed, Estimated PCD: 2023-01-10
Product
ErythropoietinClinical trial
Istradefylline for Parkinson Disease Cognitive ImpairmentStatus: Recruiting, Estimated PCD: 2025-07-01
Product
IstradefyllineClinical trial
Randomized Study to Evaluate Strategies to Address Cognitive Fog in Long-COVID-19 PatientsStatus: Terminated, Estimated PCD: 2023-05-18
Product
Tau PET scanClinical trial
XanaCIDD: A Double-Blind, Randomized, Placebo Controlled, Parallel-Group Trial to Assess the Safety, Tolerability, and Efficacy of Xanamem® in Adults With Major Depressive Disorder and Impaired CognitionStatus: Active (not recruiting), Estimated PCD: 2024-07-15
Product
Xanamem™Clinical trial
Efficacy of Cariprazine in Improving Cognitive Functioning in Euthymic Patients With Bipolar I Disorder: A Proof of Concept Randomized, Double Blind Placebo Controlled TrialStatus: Recruiting, Estimated PCD: 2025-09-30
Product
CariprazineClinical trial
Randomized, Double-Blinded, Placebo-Controlled Study Evaluating Vortioxetine for Cognitive Deficits in Persons With Post-COVID-19 ConditionStatus: Completed, Estimated PCD: 2023-02-22
Product
VortioxetineClinical trial
1/2-Dopaminergic Dysfunction in Late-Life Depression (The D3 Study)Status: Terminated, Estimated PCD: 2021-10-27
Product
Carbidopa/levodopaClinical trial
Cognitive Functions and Mood During Thyrotropin Suppressive Therapy in Patients With Differentiated Thyroid CarcinomaStatus: Recruiting, Estimated PCD: 2023-12-01
Product
TSH-suppressive therapyClinical trial
Effects of Erythropoietin on Cognitive Functions and Neural Activity in Cognitively Impaired Remitted Patients With Bipolar Disorder or Recurrent Depressive Disorder and Healthy People: Study Protocol for a Randomized, Controlled TrialStatus: Completed, Estimated PCD: 2022-10-01
Clinical trial
Multi-Modal Imaging of Psychostimulant Effects on Executive Function Post-RRSOStatus: Completed, Estimated PCD: 2022-04-30
Product
LisdexamfetamineClinical trial
Study of Nasal Insulin to Fight Forgetfulness (SNIFF) - 3-Week Aptar CPS DeviceStatus: Not yet recruiting, Estimated PCD: 2029-05-01
Clinical trial
Clinical Evaluation of Acupuncture Treatment on Alzheimer's Disease in APOE e4 Carriers and Non-Carriers: A Randomized Controlled TrialStatus: Not yet recruiting, Estimated PCD: 2026-11-30
Product
Donanemab