Indication
Septic shock
70 clinical trials
69 products
4 drugs
Product
AdrecizumabClinical trial
A Double-Blind, Placebo-Controlled, Randomized, Multicenter, Proof of Concept and Dose-Finding Phase II Clinical Trial to Investigate the Safety, Tolerability and Efficacy of ADRECIZUMAB in Patients With Septic Shock and Elevated AdrenomedullinStatus: Completed, Estimated PCD: 2019-12-20
Product
GEM00220Clinical trial
Advanced Mesenchymal Enhanced Cell THerapY for SepTic PatientsStatus: Terminated, Estimated PCD: 2023-08-10
Product
PlaceboClinical trial
Effect of Early Administration of Albumin 20% Versus Crystalloid During Resuscitation of Patient With Septic Shock: a Randomized Controlled TrialStatus: Not yet recruiting, Estimated PCD: 2024-11-01
Product
AlbuminProduct
VBI-SClinical trial
VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock PatientsStatus: Not yet recruiting, Estimated PCD: 2024-08-01
Clinical trial
Human Albumin Treatment in Adult Septic Shock. A Study Evaluating Immune Response and Organ Failure.Status: Not yet recruiting, Estimated PCD: 2025-11-01
Product
Human AlbuminClinical trial
VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock PatientsStatus: Active (not recruiting), Estimated PCD: 2023-12-31
Clinical trial
A Phase II Open Label Randomised Controlled Clinical Trial of Different Dosing Regimens of Fludrocortisone in Septic Shock With Assessment of Temporal Changes in Hormonal, Inflammatory, and Genetic Markers of Vascular ResponsivenessStatus: Completed, Estimated PCD: 2023-04-30
Product
FludrocortisoneClinical trial
Effects of Glucocorticoid Combined With Vitamin C and Vitamin B1 Versus Hydrocortisone Alone on Microcirculation in Severe Septic ShockStatus: Completed, Estimated PCD: 2020-01-01
Product
GlucocorticoidClinical trial
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged VentilationStatus: Completed, Estimated PCD: 2021-12-01
Product
MeropenemClinical trial
Effect of Bronchoscopy on the Outcome of Patients With Severe Sepsis With ARDS and Complicated by VAP From Prolonged VentilationStatus: Completed, Estimated PCD: 2021-12-01
Clinical trial
Vitamin C to Reduce Exogenous Vasopressor Dose in Septic Shock; a Randomized Clinical TrialStatus: Withdrawn, Estimated PCD: 2022-12-01
Product
Vitamin CProduct
PlacebosClinical trial
Treating Vitamin C Deficiency in Septic Shock: Would it Help?Status: Completed, Estimated PCD: 2023-01-31
Product
Ascorbic acidClinical trial
A Phase I Trial Evaluating the Safety, Tolerability and Pharmacokinetics of Intravenously Administered M6229 in Critically Ill Sepsis Patients - "HistoSeps"Status: Completed, Estimated PCD: 2023-09-28
Product
M6229Clinical trial
Comparative Study Between High and Low Dose Methylene Blue Infusion in Septic Cancer Patients. A Randomized Blinded Controlled StudyStatus: Recruiting, Estimated PCD: 2024-02-29
Product
Normal salineProduct
Methylene BlueClinical trial
Oral Bedtime Melatonin in Critically Ill PatientsStatus: Not yet recruiting, Estimated PCD: 2026-02-01
Product
MelatoninClinical trial
Days Alive and Out of Hospital for Patients With SepsisStatus: Completed, Estimated PCD: 2024-02-23
Product
Hydroxyethyl starchProduct
HydrocortisoneClinical trial
DPP3, Angiotensin II, and Renin Kinetics in Sepsis (DARK-Sepsis) Pilot: Serum Biomarkers to Predict Response to Angiotensin II vs. Standard-of-care Vasopressor Therapy in the Treatment of Septic Shock, a Randomized Controlled Pilot TrialStatus: Recruiting, Estimated PCD: 2024-09-15
Product
Angiotensin IIClinical trial
Haemodynamic Effects of Paracetamol (Acetaminophen) as Extended Intravenous Infusion Versus Intravenous Bolus in Septic Shock PatientsStatus: Completed, Estimated PCD: 2022-11-01
Product
ParacetamolClinical trial
Early Administration of Vitamin C in Patients With Sepsis or Septic Shock in Emergency Departments: a Multicentre, Double Blinded, Randomized Controlled Trial: the C-EASIE TrialStatus: Completed, Estimated PCD: 2023-08-31
Clinical trial
Endotoxins and Cytokines Removal During Continuous Hemofiltration With oXiris™Status: Completed, Estimated PCD: 2022-06-03
Product
Arterial blood samplingProduct
Ultrafiltrate samplingClinical trial
Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot StudyStatus: Completed, Estimated PCD: 2014-01-01
Clinical trial
Clinical Efficacy of Megadose Vitamin C in Sepsis (CEMVIS): A Multicenter, Randomized, Single-blind, Placebo-controlled Clinical TrialStatus: Recruiting, Estimated PCD: 2024-12-04
Product
5% Glucose InjectionClinical trial
Efficacy and Safety of 72-hour Infusion of Prostacyclin (1 Nanogram(ng)/Kilo(kg)/Minute(Min)) in Patients With Septic Shock Induced Endotheliopathy - a Multicentre Randomized, Placebo-controlled, Blinded, Investigator-initiated Trial"Status: Completed, Estimated PCD: 2022-06-28
Product
IloprostProduct
Isotonic salineClinical trial
Comparing the Hemodynamic Effects of Bolus of Ketamine and Fentanyl in Patients With Septic Shock: a Randomized Controlled TrialStatus: Completed, Estimated PCD: 2023-12-15
Drug
KetamineProduct
FentanylClinical trial
LANdiolol MIcrocirculatory Effects During Septic chOcStatus: Recruiting, Estimated PCD: 2024-01-01
Product
LandiololClinical trial
Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic ShockStatus: Completed, Estimated PCD: 2020-10-31
Product
Tranexamic acidClinical trial
Pharmacokinetics of Caspofungin in Critically Ill PatientsStatus: Completed, Estimated PCD: 2018-08-06
Product
CaspofunginClinical trial
Proton Pump Inhibitors (PPI) as a New Strategy for Therapy in Sepsis: Clinical Trial to Reduce Severity of Organ Failure and in Vitro Experiments to Search Specific Hallmarks in Monocytes From Septic Patients and to Characterize the Mechanism of Action of PPIStatus: Completed, Estimated PCD: 2023-08-21
Product
EsomeprazoleClinical trial
Midodrine Use in the Recovery Phase of Septic ShockStatus: Withdrawn, Estimated PCD: 2018-05-02
Product
midodrineClinical trial
Blessing or Curse? Combined Vitamin Therapy in Non Viral Septic Shock.Status: Completed, Estimated PCD: 2020-03-01
Clinical trial
Effect of Dexmedetomidine vs Esmolol or Placebo on Cerebral Hemodynamics in Septic Shock: A Randomized Clinical Trial.Status: Completed, Estimated PCD: 2021-11-01
Product
DexmedetomidineProduct
EsmololClinical trial
Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic ShockStatus: Active (not recruiting), Estimated PCD: 2023-10-01
Clinical trial
Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock: a Randomized Clinical Study (VITAMIN TRIAL)Status: Terminated, Estimated PCD: 2022-07-14
Clinical trial
The Effect Of Resuscitation Guided By Two Different Dynamic Parameters On Time To Normalization Of The Capillary Refill Time In Adult Patients With Septic Shock, A Randomized Controlled Prospective StudyStatus: Recruiting, Estimated PCD: 2024-07-01
Product
Group VTIProduct
Group IVCClinical trial
The Effect of Vasopressor Therapy on Renal Perfusion in Patients With Septic Shock - a Mechanistically Focussed Randomized Control StudyStatus: Not yet recruiting, Estimated PCD: 2026-01-01
Product
VasopressinProduct
NorepinephrineClinical trial
Umbilical Mesenchymal Stromal Cells as Cellular Immunotherapy for Septic Shock: A Multi-Center, Double Blind, Phase II Randomized Controlled TrialStatus: Recruiting, Estimated PCD: 2026-09-30
Clinical trial
Prospective, Randomized Trial of Personalized Medicine With Pentaglobin® After Surgical Infectious Source Control in Patients With Peritonitis (PEPPER Trial).Status: Recruiting, Estimated PCD: 2027-09-01
Product
PentaglobinClinical trial
A Randomized Clinical Trial of the Safety and Feasibility of Metformin as a Treatment for Sepsis Induced AKI.Status: , Estimated PCD: 2026-11-08
Product
MetforminDrug
VarlilumabClinical trial
Temporal Changes in Plasma Lactate Concentration in Critically Ill Patients With Septic Shock Treated With Restrictive Compared to Standard Fluid TherapyStatus: Completed, Estimated PCD: 2022-12-28
Product
Resuscitation fluidClinical trial
Septic cArdiac Deficiency and MenIngococcal seveRe SepsisStatus: Completed, Estimated PCD: 2018-07-11
Product
BNPClinical trial
Interstitial Fluid Composition in Patients With Septic Versus Non-septic Shock: an Exploratory Pilot StudyStatus: Recruiting, Estimated PCD: 2025-01-01
Product
Interstitial Fluid SamplingProduct
Blood SamplingClinical trial
Evaluation of the Hemodynamics Effects of Fludrocortisone on the Pressor Response to Noradrenaline in Septic Shock PatientsStatus: , Estimated PCD: 2024-06-01
Clinical trial
Natriuresis as a Predictor of the Haemodynamic Response to Steroid Replacement Therapy in Patients in Septic ShockStatus: Completed, Estimated PCD: 2017-11-15
Product
Aldosterone / ReninProduct
NatriuresisClinical trial
Stress Hydrocortisone In Pediatric Septic ShockStatus: Recruiting, Estimated PCD: 2026-09-30
Clinical trial
Albumin and Crystalloid Administration in Septic Shock (ALCAMIST): Multi-center, Open Labelled Randomized Controlled TrialStatus: Recruiting, Estimated PCD: 2024-09-30
Drug
CisplatinClinical trial
The Construction and Application of Therapeutic System of Intelligent Decision-Oriented Hemodynamic Organized Therapy for Shock PatientsStatus: Recruiting, Estimated PCD: 2025-01-01
Product
norepinephrine+vasopressinClinical trial
MUNI-SEP TRIAL-The Role of Ulinastatin in Preventing Severe Sepsis and Consequent Morbidities and Mortality; A Randomized Clinical Trial in Pakistan.Status: Recruiting, Estimated PCD: 2023-10-01
Drug
UlinastatinClinical trial
A Crossover, Cluster Randomised Controlled Trial of Selective Decontamination of the Digestive Tract in Intensive Care Unit Patients (SuDDICU)Status: Completed, Estimated PCD: 2023-04-26
Product
SDD Oral PasteProduct
SDD Gastric SuspensionProduct
Intravenous AntibioticClinical trial
Renin and Renal Biomarker Response to Angiotensin II Versus Controls in Septic Shock: An Open-Label StudyStatus: Completed, Estimated PCD: 2023-07-24
Clinical trial
Clinical Study Evaluating the Efficacy and Safety of Adjunctive Use of Midodrine in Septic Shock PatientsStatus: Recruiting, Estimated PCD: 2024-04-30
Product
MidodrineClinical trial
Dosing of Extracorporeal Cytokine Removal In Septic Shock (DECRISS): a Prospective, Randomized, Multicenter Clinical TrialStatus: , Estimated PCD: 2026-10-31
Product
Standard medical therapyClinical trial
Effect of Combined Vitamin C, Stress-dose Steroids, and Thiamine on Cerebral Autoregulation and Functional Outcomes of Patients With Septic ShockStatus: Recruiting, Estimated PCD: 2025-05-01
Clinical trial
Randomized Clinical Trial Comparing Noradrenaline Plus Placebo Versus Terlipressin Plus Noradrenaline for the Treatment of Septic ShockStatus: Recruiting, Estimated PCD: 2024-11-01
Product
Noradrenaline + TerlipressinClinical trial
Pentaglobin as Early Adjuvant Treatment for Febrile Neutropenia in Acute Leukemia or Allogeneic Hematopoietic Stem Cell Transplant Patients Colonized by Carbapenem-resistant Enterobacteriaceae (CRE) or Pseudomonas Aeruginosa (PA)Status: Recruiting, Estimated PCD: 2024-06-30
Clinical trial
The Efficacy of Adjunctive Use of Ondansetron in Patients With Sepsis and Septic ShockStatus: Recruiting, Estimated PCD: 2023-06-01
Product
OndansetronClinical trial
Comparison of Landiolol Versus Standard of Care for Prevention of Mortality in Patients Hospitalized for a Septic Shock With Hypercontractility: an Open Label Prospective Randomized StudyStatus: Recruiting, Estimated PCD: 2024-02-01
Clinical trial
Norepinephrine Administration Through a Midline Catheter in an Intermediate Care Unit - a Retrospective Study of Complications and Patient OutcomesStatus: Completed, Estimated PCD: 2024-03-01
Clinical trial
Empirical Meropenem Versus Piperacillin/Tazobactam for Adult Patients With Sepsis (EMPRESS) TrialStatus: Not yet recruiting, Estimated PCD: 2028-06-30
Product
Piperacillin/TazobactamClinical trial
Dexmedetomidine and Vasopressin (DEX-PRESSIN) for Reducing In-hospital Mortality in Septic Shock Patients: A Protocol for Randomized Controlled Trial (DecatSepsis-2)Status: Not yet recruiting, Estimated PCD: 2025-12-01
Product
DEX-PRESSINProduct
Standard of CareClinical trial
An Open-label, Single-arm, Single-center Study Evaluating the Hemodynamic Response to Angiotensin-II When Used as the Second Vasopressor Agent for Septic ShockStatus: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
A Randomized Controlled Pilot Study Evaluating the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic ShockStatus: Terminated, Estimated PCD: 2023-01-31
Product
5% GlucoseClinical trial
Piperacillin-tazobactam and Temocillin as Carbapenem-alternatives for the Treatment of Severe Infections Due to Extended-spectrum Beta-lactamase-Producing Gram-negative Enterobacteriaceae in the Intensive Care UnitStatus: Recruiting, Estimated PCD: 2026-04-01
Clinical trial
Decatecholaminisation With Dexmedetomidine for Reduction of Mortality in Septic Shock: A Randomized Clinical TrialStatus: Completed, Estimated PCD: 2023-02-01
Clinical trial
Evaluation of Immunosuppression in Septic Shock: Biomarkers and Pharmacological RestorationStatus: Recruiting, Estimated PCD: 2024-11-21
Product
Blood samplingClinical trial
Norepinephrine and Vasopressin for Rescue Versus Early Vasopressin for Vasopressor Dependent Sepsis: An Open-label, Multicenter, Randomized, Controlled Trial: NoVaStatus: Not yet recruiting, Estimated PCD: 2027-08-01
Clinical trial
Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic ShockStatus: Recruiting, Estimated PCD: 2026-05-15
Product
Vasopressin infusionClinical trial
A Multicenter, Prospective, Randomized, Placebo-controlled, Double-blind, Multi-arm, Multi-stage Clinical Trial of Ivabradine for Heart Rate Control In Septic ShockStatus: Recruiting, Estimated PCD: 2024-09-24
Product
IvabradineClinical trial
Stratégie Transfusionnelle érythrocytaire Dans la réanimation du Choc Septique du Patient d'Onco-hématologie : Essai randomisé Multicentrique TRANSPORT [TRANSfusion in Patients With Onco-hematological Malignancies ResusciTated From Septic Shock]Status: Completed, Estimated PCD: 2024-02-28
Clinical trial
Exploratory Study on the Efficacy and Safety of Methylene Blue in Treating Severe Septic Shock Patients: A Prospective, Randomized, Controlled TrialStatus: Not yet recruiting, Estimated PCD: 2026-06-20
Product
Normal Saline Control Group