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tobacco dependence

76 clinical trials

53 products

3 drugs

Product
Nicoderm
Clinical trial
A Randomized Study to Evaluate Harm Reduction Products as a Second Line Intervention for Adult Smokers Who Do Not Quit With Nicotine Replacement Therapy (NRT)
Status: Active (not recruiting), Estimated PCD: 2024-08-31
Product
Nicorette
Product
Nicorette Lozenge
Product
Cytisinicline
Clinical trial
A Second Multicenter, Double-blind, Randomized, Placebo-controlled Phase 3 Trial Evaluating the Efficacy and Safety of Cytisinicline in Adult Smokers
Status: Completed, Estimated PCD: 2023-03-21
Product
Placebo
Product
SBP-9330
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled, First-In-Human Study to Assess Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of SBP-9330 (With a Nested Food-Effect Arm) After Oral Administration in Healthy Subjects
Status: Completed, Estimated PCD: 2023-03-06
Product
Nicorette 4Mg Chewing Gum
Product
NFL-101
Clinical trial
Phase II Study Assessing Efficacy and Safety of NFL-101 on Reduction of Reinforcing Properties of Cigarettes (PRECESTO Trial)
Status: Completed, Estimated PCD: 2023-09-15
Clinical trial
A Four Way Crossover Thorough QT/QTc Study to Evaluate the Electrocardiographic Effects of Therapeutic and Supratherapeutic Doses of Cytisinicline in Healthy Smokers
Status: Completed, Estimated PCD: 2022-12-23
Product
Moxifloxacin
Clinical trial
A Phase 1 Study to Investigate the Effect of Food on the Bioavailability of a Single Cytisinicline 3 mg Tablet and Evaluation of the Pharmacokinetics of Multiple 3 mg Doses (Three Times Daily) in Healthy Adult Smokers
Status: Completed, Estimated PCD: 2023-09-21
Clinical trial
Study Assessing Efficacy and Safety of NFL-101 as a Tobacco Cessation Therapy
Status: Recruiting, Estimated PCD: 2024-07-01
Clinical trial
Efficacy of Centanafadine SR as a Potential Smoking Cessation Treatment
Status: Completed, Estimated PCD: 2022-05-31
Clinical trial
The Effectiveness of Using E-Cigarettes as Harm Reduction Strategy for Smoking Cessation and Decreasing Risk of Diseases Among Heavy Smokers: an Open-label Randomized Controlled Trial
Status: Withdrawn, Estimated PCD: 2024-04-30
Product
Electronic cigarettes
Product
Centanafadine
Clinical trial
Efficacy and Tolerability of Combination Varenicline With Hydroxyzine as a Potential Smoking Cessation Treatment
Status: Completed, Estimated PCD: 2019-12-15
Clinical trial
A Multicenter, Double-blind, Randomized, Placebo-controlled Phase 3 Trial Evaluating the Efficacy and Safety of Cytisinicline in Adult Smokers
Status: Completed, Estimated PCD: 2021-12-23
Product
Varenicline
Product
Hydroxyzine
Clinical trial
A Randomized Controlled Trial to Determine the Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette
Status: Recruiting, Estimated PCD: 2024-02-28
Product
Bupropion
Product
Zonisamide
Clinical trial
Assisting Smokers to Switch to an e-Cigarette by Accelerating Learning of Adaptive Habits Using D-cycloserine
Status: Recruiting, Estimated PCD: 2024-02-28
Product
d-cycloserine
Clinical trial
Smartphone-Based Smoking Cessation and Mental Health Intervention
Status: Recruiting, Estimated PCD: 2024-12-01
Product
Smart-T
Product
Smart-T Mental Health
Product
QuitGuide + NRT
Clinical trial
An Integrated Smoking Cessation Intervention Model of Brief Advice, Nicotine Replacement Therapy and Mobile Health Support for Smoking Parents to Increase Abstinence and Protect Children From Tobacco Smoke Exposure: A Randomized Controlled Trial
Status: Recruiting, Estimated PCD: 2025-11-01
Product
Nicotine Replacement Therapy
Clinical trial
Comparative Effectiveness Trial of Tobacco Cessation Treatments Among Cancer Patients Who Smoke
Status: , Estimated PCD: 2026-06-01
Product
Nicotine Patch
Clinical trial
A Multicenter, Open-Label Study Assessing Long-Term Exposure With Cytisinicline 3 mg TID
Status: Not yet recruiting, Estimated PCD: 2025-12-31
Clinical trial
Strategies to Promote Cessation in Smokers Who Are Not Ready To Quit (PACE)
Status: Completed, Estimated PCD: 2020-06-16
Product
Pharmacological
Clinical trial
PARQuit Smoking Cessation Intervention for Adults With Serious Mental Illness
Status: Recruiting, Estimated PCD: 2025-07-01
Clinical trial
Gain-framed Messages and NRT Sampling to Promote Smoking Cessation in Lung Cancer Screening Programs
Status: Active (not recruiting), Estimated PCD: 2023-11-10
Product
Gain-framed messaging plus NRT
Clinical trial
Treating Nicotine Addiction in Caregivers of Children at American Family Children's Hospital
Status: Recruiting, Estimated PCD: 2024-10-01
Product
Nicotine Replacement
Clinical trial
Optimizing Smoking Cessation Interventions for People Living With HIV in Nairobi, Kenya
Status: Completed, Estimated PCD: 2023-07-25
Clinical trial
Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)
Status: Recruiting, Estimated PCD: 2025-11-01
Product
Nicotine
Clinical trial
A Mechanistic Test of Treatment Strategies to Foster Practice Quitting
Status: Recruiting, Estimated PCD: 2027-05-30
Clinical trial
Improving Smoking Abstinence Outcomes in the African American Community Through Extended Treatment
Status: Recruiting, Estimated PCD: 2026-01-15
Clinical trial
A Translational Randomized Clinical Trial of Varenicline Sampling to Promote Smoking Cessation and Scalable Treatment Dissemination
Status: Recruiting, Estimated PCD: 2025-03-01
Clinical trial
Implementing Tobacco Treatment in Low Dose CT Lung Cancer Screening Sites
Status: Active (not recruiting), Estimated PCD: 2025-10-01
Clinical trial
A Randomized Controlled Trial (RCT) to Compare Efficacy of Nicotine Replacement Therapy (NRT) Versus Electronic Cigarettes (EC) for Quitting Tobacco Smoking in Pakistan
Status: Not yet recruiting, Estimated PCD: 2025-05-31
Clinical trial
Varenicline and Mobile Behavioral Assistance for Tobacco Cessation in HIV Care in India
Status: Recruiting, Estimated PCD: 2025-07-20
Clinical trial
Phone Enabled Implementation of Cessation Support (PHOENICS)
Status: Recruiting, Estimated PCD: 2026-06-01
Clinical trial
Smartphone Based Smoking Cessation Intervention
Status: Completed, Estimated PCD: 2023-11-17
Product
Smart-T + NRT
Product
QuitGuide
Clinical trial
Randomized Trial of Automated Video-Assisted Smoking Treatment for People Living With HIV (Project RESOURCE)
Status: Recruiting, Estimated PCD: 2025-03-31
Clinical trial
Multi-method Pilot Study to Evaluate the Interest of Music Therapy Associated to Nicotine Replacement Therapy (NRT) Versus NRT Alone on Craving Related to Smoking Cessation in Health Staff.
Status: Recruiting, Estimated PCD: 2025-01-10
Product
Music intervention
Clinical trial
Early-phase Studies of a Tailored Evidence-Based Smoking Cessation mHealth App for Persons Living With HIV
Status: Completed, Estimated PCD: 2022-06-02
Clinical trial
Smoking Cessation Treatment for Head & Neck Cancer Patients: Acceptance and Commitment Therapy
Status: Active (not recruiting), Estimated PCD: 2025-09-30
Clinical trial
Combining Varenicline and Guanfacine for Smoking Cessation
Status: Recruiting, Estimated PCD: 2024-08-31
Product
Guanfacine ER
Clinical trial
Multi-method Pilot Study to Evaluate the Interest of Music Therapy Associated to Nicotine Replacement Therapy (NRT) Versus NRT Alone on Craving Related to Smoking Cessation in Students.
Status: Recruiting, Estimated PCD: 2025-09-01
Clinical trial
PeRiopEratiVE smokiNg cessaTion Trial
Status: Recruiting, Estimated PCD: 2026-07-01
Product
Cytisine
Clinical trial
Using Sleep Health to Optimize Smoking Cessation Treatment Response in HIV-Positive Adults
Status: Recruiting, Estimated PCD: 2025-02-28
Clinical trial
A Comparison of the Effectiveness of Combination Varenicline and Oral Nicotine Replacement Therapy Versus Varenicline Alone for Smoking Cessation: a Pilot Study
Status: Terminated, Estimated PCD: 2022-02-07
Product
Oral Nicotine Replacement Therapy
Clinical trial
Developing and Pilot Testing a Remote Smoking Cessation Digital Therapeutic for Individuals With Serious Mental Illness
Status: Not yet recruiting, Estimated PCD: 2025-03-01
Product
LTQ
Clinical trial
Modifying Progesterone and Estradiol Levels to Prevent Postpartum Cigarette Smoking Relapse and Reduce Secondhand Smoke Exposure in Infants and Children
Status: Recruiting, Estimated PCD: 2025-06-02
Product
Progesterone
Clinical trial
NRT Sampling and Selection to Increase Medication Adherence
Status: Completed, Estimated PCD: 2020-05-31
Product
Combination NRT
Clinical trial
Partnering With a State Food Bank to Provide Tobacco Treatment to Underserved Smokers (Project NOURISH)
Status: Recruiting, Estimated PCD: 2025-08-01
Clinical trial
Analysis of Aldehyde Biomarkers of Exposure and Host Response
Status: Terminated, Estimated PCD: 2007-09-09
Product
Nicotine polacrilex
Clinical trial
Integration of Smoking Cessation Into Standard Treatment for People Receiving Opioid Agonist Therapy Who Are Smoking Tobacco: Protocol for a Randomised Controlled Trial
Status: Active (not recruiting), Estimated PCD: 2023-10-01
Clinical trial
Project HOPES: Healthy Options for Pain and Ending Smoking. A Program for Cancer Survivors.
Status: Not yet recruiting, Estimated PCD: 2025-03-09
Clinical trial
Cytisine and E-cigarettes With Supportive Text-messaging for Smoking Cessation
Status: Active (not recruiting), Estimated PCD: 2024-04-01
Product
Cytisine + Nicotine
Clinical trial
BREATHE 2 Cluster-randomized Trial of Health System Changes to Increase Reach of Smoking Cessation Treatments
Status: , Estimated PCD: 2024-10-01
Product
Wisconsin Tobacco QuitLine
Product
Primary Care Provider
Clinical trial
Suvorexant to Reduce Symptoms of Nicotine Use: A Double-blind, Placebo-controlled Study
Status: Recruiting, Estimated PCD: 2024-09-01
Product
Suvorexant
Product
BREATHE 2 Cessation Study
Clinical trial
Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation
Status: Completed, Estimated PCD: 2023-06-14
Product
Isradipine
Clinical trial
Use of Nicotine Replacement Therapy (NRT) Sample and Brief Smoking Cessation Advice for Recruiting Smokers to Smoking Cessation Services and Motivating Quit Attempts
Status: Completed, Estimated PCD: 2019-12-31
Product
Nicotine replacement therapy
Clinical trial
A Test of Short and Long Term Naturalistic Outcomes of Smokers Who Sample Smokeless Tobacco
Status: Completed, Estimated PCD: 2016-03-01
Product
Potentially Reduced Exposure Product (PREP)
Clinical trial
Glucagon-like Peptide-1 Receptor Agonists as Novel Pharmacotherapies for Nicotine Dependence
Status: Completed, Estimated PCD: 2022-05-25
Product
Liraglutide
Drug
Varlilumab
Clinical trial
High Dose Bupropion Treatment for Smoking Cessation - Pilot Study
Status: Terminated, Estimated PCD: 2023-07-01
Clinical trial
Contingency Management to Promote Smoking Abstinence in Cancer Patients
Status: Recruiting, Estimated PCD: 2025-06-30
Product
Contingency Management
Product
Standard Care
Clinical trial
Smoking Cessation is Associated With Short-term Improvement of Vascular Health in a Cohort of People Living With HIV in Rio de Janeiro, Brazil.
Status: Completed, Estimated PCD: 2022-04-15
Clinical trial
The Acute Effects of Moderate Intensity Exercise and Nicotine on Cognition in Smokers
Status: Completed, Estimated PCD: 2018-04-01
Clinical trial
Randomized, Two Arm Parallel, Clinical Trial to Compare Effectiveness of Different Tobacco Harm Reduction Products in General Adult Population in Low Middle Income Countries
Status: Not yet recruiting, Estimated PCD: 2025-03-01
Clinical trial
Ending Tobacco Use Through Interactive Tailored Messaging for Cambodian People Living With HIV/AIDS (Project END-IT)
Status: Recruiting, Estimated PCD: 2025-03-01
Clinical trial
Comparing the Effects of Augmented Doses of Nicotine Replacement Therapy on Quitting Cigarettes and E-cigarettes
Status: Recruiting, Estimated PCD: 2024-09-01
Product
Regular Nicotine patch and lozenge
Product
Augmented Nicotine
Clinical trial
Efficacy and Safety of E-cigarettes for Smoking Cessation in Middle-aged Heavy Smokers
Status: Completed, Estimated PCD: 2021-03-31
Clinical trial
Individualizing Pharmacotherapy: A Novel Optimization Strategy to Increase Smoking Cessation in the African American Community
Status: Completed, Estimated PCD: 2021-11-30
Clinical trial
A Pilot SMART Pre- and Post-testing of an Integrative Mindfulness-Based Smoking Cessation Intervention for HIV Patients
Status: Recruiting, Estimated PCD: 2024-12-09
Clinical trial
Deep rTMS and Varenicline for Smoking Cessation: A Pilot Study Exploring the Efficacy of a Combined Treatment Approach
Status: Completed, Estimated PCD: 2022-09-13
Clinical trial
Behavioral Mechanisms of Lorcaserin Treatment for Smoking Cessation
Status: Terminated, Estimated PCD: 2020-02-26
Product
Lorcaserin
Clinical trial
Cytisine: Testing Its Potential as a Therapeutic Strategy for Smoking Cessation Among People With Concurrent Alcohol Use Disorder
Status: Recruiting, Estimated PCD: 2024-01-01
Clinical trial
Ketamine and Motivational Enhancement Therapy for the Treatment of Tobacco Use Disorder
Status: Recruiting, Estimated PCD: 2024-05-01
Drug
Ketamine
Clinical trial
A Randomized Open-label, Superiority, Multicenter, Two-arm Intervention Study of the Effect of "High-intensity" vs. 'Low-intensity' Smoking Cessation Intervention in Active Smokers With COPD
Status: Withdrawn, Estimated PCD: 2026-01-01
Product
Low-intensity smoking cessation intervention
Clinical trial
Coordinating Smoking Cessation Treatment With Menstrual Cycle Phase to Improve Quit Outcomes: A Randomized Controlled Trial
Status: Recruiting, Estimated PCD: 2024-08-31
Clinical trial
Efficacy of Naltrexone in Women's Smoking Cessation
Status: Completed, Estimated PCD: 2009-06-01
Product
Naltrexone
Clinical trial
Effectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary Care
Status: Recruiting, Estimated PCD: 2025-03-01
Product
Algorithm Treatment
Clinical trial
Multifactorial Intervention of Primary Prevention in High Risk Subjects: a Randomized Trial
Status: Active (not recruiting), Estimated PCD: 2024-12-31
Drug
Aspirin
Clinical trial
Varenicline for Treatment of E-cigarette Dependence
Status: Completed, Estimated PCD: 2023-09-01
Clinical trial
Mindfulness Training Plus Oxytocin to Reduce Smoking and Craving Among Smokers in Withdrawal
Status: Terminated, Estimated PCD: 2023-12-31
Product
Oxytocin
Clinical trial
Dual Use Cessation: A MOST Screening Trial to Identify Effective Interventions to Help People Who Smoke and Vape
Status: Not yet recruiting, Estimated PCD: 2028-07-01