Indication
Progressive Multifocal Leukoencephalopathy
11 clinical trials
12 products
1 drug
Clinical trial
An Observational Study Utilising Data From the US Tysabri TOUCH Programme and Select EU MS Registries to Estimate the Risk of Progressive Multifocal Leukoencephalopathy (PML) and Other Serious Opportunistic Infections Among Patients Who Were Exposed to an MS Disease Modifying Treatment Prior to Treatment With TysabriStatus: Completed, Estimated PCD: 2023-12-31
Product
TysabriClinical trial
Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of ALVR105 Posoleucel (ALVR105,Viralym-M) Compared to Placebo for the Prevention of AdV, BKV, CMV, EBV, HHV-6, and JCV Infection and/or Disease, in High-Risk Patients After Allogeneic Hematopoietic Cell TransplantStatus: Terminated, Estimated PCD: 2024-01-31
Product
PlaceboProduct
PosoleucelClinical trial
Phase 2/3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Safety and Efficacy of ALVR105 (Viralym-M) Compared to Placebo for the Prevention of AdV, BKV, CMV, EBV, HHV-6, and JCV Infection and/or Disease, in High-Risk Patients After Allogeneic Hematopoietic Cell TransplantStatus: Completed, Estimated PCD: 2023-01-19
Clinical trial
ASCEND-JC: A Multi-center, Randomized, Double-blind, Phase 2 Study, Evaluating JCPyV-specific T Cell Therapy for the Treatment of PMLStatus: Not yet recruiting, Estimated PCD: 2024-03-01
Product
CE-VST01-JCClinical trial
Study Assessing the Feasibility, Safety and Efficacy of Genetically Engineered Glucocorticoid Receptor Knock Out Virus Specific CTL Lines for Viral Infections in Immunosuppressed Cancer PatientsStatus: Recruiting, Estimated PCD: 2025-01-31
Clinical trial
A Pilot Study of NT-I7, a Long-Acting Recombinant IL-7 Molecule, as an Immune Reconstitution Strategy for Lymphopenia in Patients With Progressive Multifocal LeukoencephalopathyStatus: Recruiting, Estimated PCD: 2026-01-31
Drug
NT-I7Clinical trial
Central Nervous System Uptake of Anti-CD8+ T Cell Minibodies in Multiple Sclerosis and Progressive Multifocal Leukoencephalopathy: A Pilot StudyStatus: Recruiting, Estimated PCD: 2024-06-30
Product
Zr-Df-crefmirlimabClinical trial
Pembrolizumab in Progressive Multifocal Leukoencephalopathy (PML) in Immunocompromised Patients Without HIV InfectionStatus: Not yet recruiting, Estimated PCD: 2028-04-01
Product
PembrolizumabClinical trial
A Pilot Study of Adoptive Cellular Immunotherapy for Progressive Multifocal Leukoencephalopathy With Ex Vivo Generated Polyomavirus-Specific T-cellsStatus: Completed, Estimated PCD: 2019-12-13
Product
PyVSTClinical trial
Phase II Study Assessing the Effect of BK Specific CTL Lines Generated by Ex Vivo Expansion in Patients With BK Virus Infection and JC Virus InfectionStatus: Recruiting, Estimated PCD: 2024-07-31
Clinical trial
Dynamics of T Cell Expression of Immune Checkpoint Molecules in Progressive Multifocal LeukoencephalopathyStatus: Recruiting, Estimated PCD: 2023-12-31
Product
Spinal tapProduct
Neurological evaluation