Indication
Heart Failure with Reduced Ejection Fraction
44 clinical trials
51 products
2 drugs
Product
TovinontrineClinical trial
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Finding Study to Assess the Safety and Effectiveness of Tovinontrine in Patients With Chronic Heart Failure With Reduced Ejection FractionStatus: Recruiting, Estimated PCD: 2025-10-01
Product
PlaceboProduct
DanicamtivClinical trial
An Open-label, Single-sequence Study to Evaluate the Effect of Coadministration of Danicamtiv on the Pharmacokinetics of Midazolam in Patients With Stable Heart Failure With Reduced Ejection FractionStatus: Completed, Estimated PCD: 2024-03-15
Product
MidazolamClinical trial
Phase IV, Double-Blind, Placebo-Controlled, Randomized-Withdrawal Trial Evaluating Sodium Zirconium Cyclosilicate (SZC) for the Management of Hyperkalaemia in Patients With Symptomatic Heart Failure With Reduced Ejection Fraction and Receiving SpironolactoneStatus: Active (not recruiting), Estimated PCD: 2024-07-31
Clinical trial
Randomized, Double-blind, Placebo-controlled, Two-Part, Adaptive Design Study of Safety, Tolerability, Preliminary Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Oral Doses of MYK-491 in Patients With Stable Heart Failure With Reduced Ejection FractionStatus: Completed, Estimated PCD: 2019-10-24
Product
JK07Clinical trial
A Randomized, Double-Blind, Placebo-controlled, Single-ascending Dose Study to Assess the Safety, Tolerability, and Pharmacokinetics of JK07 in Subjects With Heart Failure With Reduced Ejection Fraction (HFrEF)Status: Completed, Estimated PCD: 2023-06-08
Product
Matching PlaceboProduct
MYK-491Product
CRD-740Clinical trial
A Phase 2, Randomized, Double-Blind, Placebo-Controlled Clinical Study to Assess the Effectiveness of CRD-740 in Subjects With Chronic Heart Failure (CARDINAL-HF)Status: Terminated, Estimated PCD: 2023-05-02
Product
LCZ696Clinical trial
A Multicenter, Randomized, Double-blind, Parallel Group, Active-controlled Study to Evaluate the Efficacy and Safety of LCZ696 Compared to Enalapril on Morbidity and Mortality in Japanese Patients With Chronic Heart Failure and Reduced Ejection Fraction.Status: Completed, Estimated PCD: 2019-02-08
Clinical trial
A Double-blind, Randomized, Placebo-controlled, Multicenter Study to Assess the Effect of Omecamtiv Mecarbil on Exercise Capacity in Subjects With Heart Failure With Reduced Ejection Fraction and Decreased Exercise ToleranceStatus: Completed, Estimated PCD: 2021-11-08
Product
EnalaprilProduct
Omecamtiv MecarbilClinical trial
Enhanced Diuresis and Natriuresis in Acute Decompensated Heart Failure Patients Treated With SGLT-2 Inhibitor and High-Dose Furosemide Plus Small-Volume Hypertonic Saline Solution: A Clinical TrialStatus: Not yet recruiting, Estimated PCD: 2026-01-31
Product
DapagliflozinProduct
Hypertonic Saline SolutionProduct
FurosemideClinical trial
Withdrawal of Pharmacological Treatment for Heart Failure Patients With Recovery From Tachycardia-induced Cardiomyopathy - WEAN-HFStatus: Not yet recruiting, Estimated PCD: 2027-01-01
Product
GDMTClinical trial
Ketones, Muscle Metabolism, and SGLT2 InhibitorsStatus: Recruiting, Estimated PCD: 2026-11-01
Product
EmpagliflozinProduct
AcipimoxClinical trial
Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 3 Study to Assess the Efficacy of Ertugliflozin on Reduction of Mitral Regurgitation in Patients With Functional Mitral Regurgitation Secondary to Left Ventricular DysfunctionStatus: Completed, Estimated PCD: 2023-11-15
Product
ErtugliflozinClinical trial
ERTU-SODIUM: Double-blind, Prospective, Randomized, Crossover, Placebo-control Study on the Effects of the SGLT2 Inhibitor Ertugliflozin on the Regulation of Interstitial Volume, Plasma Volume, Subcutaneous Sodium Storage, and the Functionality of the Subcutaneous Glycosaminoglycan Network in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF)Status: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
The Efficacy and Safety of SGLT2 Inhibitors in Improving Heart Failure in Patients With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) and Severe Renal InsufficiencyStatus: Terminated, Estimated PCD: 2024-04-16
Product
SGLT-2 inhibitorClinical trial
Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart FailureStatus: Recruiting, Estimated PCD: 2026-06-30
Product
SemaglutideClinical trial
Developing a Heart Failure Polypill to Improve Outcomes at a Safety Net Hospital: A Pilot Crossover Randomized Controlled TrialStatus: Recruiting, Estimated PCD: 2024-07-01
Product
Heart failure polypillProduct
Control RxClinical trial
Initiation of Angiotensin Receptor-neprilysin Inhibitor (ARNi) and Sodium-glucose Cotransporter-2 Inhibitors (SGLT2i) in Patients With Heart Failure With Reduced Ejection Fraction (HFrEF): the INITIATE-HFrEF Randomized Open-label TrialStatus: Recruiting, Estimated PCD: 2024-11-01
Product
Sacubitril-valsartanProduct
SGLT2 inhibitorClinical trial
The Gender-Based Differences in the Outcome of Treatment by Aldosterone Antagonists in Patients With Heart FailureStatus: Completed, Estimated PCD: 2023-07-15
Product
Potassium sparing diureticClinical trial
Ertugliflozin to Reduce Arrhythmic Burden in Implantable Cardioverter-defibrillators (ICD)/Cardiac Resynchronisation Therapy(CRT) patientS (ERASe-Trial) - a Phase III StudyStatus: Terminated, Estimated PCD: 2023-06-23
Clinical trial
Heart Failure Patients With Left Ventricular Assist Devices Being Treated With Sodium-Glucose Co-Transporter 2 InhibitorsStatus: Recruiting, Estimated PCD: 2024-09-01
Drug
SGLT2iClinical trial
Developing Oral LT3 Therapy For Heart Failure With Reduced Ejection FractionStatus: Completed, Estimated PCD: 2023-08-31
Product
LiothyronineClinical trial
Effect of Vericiguat on Endpoint Events in ACS Patients With Ejection Fraction <45%：a Prospective Preventional Clinical StudyStatus: Recruiting, Estimated PCD: 2025-10-01
Product
VericiguatClinical trial
Prevention of Age-associated Cardiac and Vascular Dysfunction Through Nrf2 Signaling Using the Nutritional Supplement SulforaphaneStatus: Recruiting, Estimated PCD: 2025-08-30
Product
SulforaphaneClinical trial
Colchicine in Acutely Decompensated Heart Failure With Reduced Ejection Fraction: a Pilot StudyStatus: Recruiting, Estimated PCD: 2026-06-01
Product
ColchicineProduct
Control/PlaceboClinical trial
Midodrine in Heart Failure With Reduced Ejection Fraction With Hypotension: A Pilot, Open-label, Randomized Controlled TrialStatus: Not yet recruiting, Estimated PCD: 2026-04-01
Product
MidodrineClinical trial
The Safety and Efficacy of Empagliflozin in Patients With End-stage Renal Disease and Heart Failure With Reduced Ejection Fraction - a Randomized Controlled TrialStatus: Not yet recruiting, Estimated PCD: 2027-12-31
Drug
VarlilumabClinical trial
Use of Determination of Drug Levels to Optimize Pharmacotherapy of Heart FailureStatus: Not yet recruiting, Estimated PCD: 2026-04-01
Product
NebivololProduct
Valsartan + SacubitrilProduct
CarvedilolProduct
BisoprololProduct
MetoprololProduct
SpironolactoneClinical trial
Effects of "ShengXian-QuYu Decoction" on Quality of Life, Symptoms, and Biomarkers in Heart Failure Patients With Reduced Ejection Fraction: a Nationwide, Multicenter, Parallel Group, Randomized, Double-Blind, Placebo-Controlled TrialStatus: Recruiting, Estimated PCD: 2025-04-30
Product
ShengXian-QuYuClinical trial
Adjunctive DobutAmine in sePtic Cardiomyopathy With Tissue Hypoperfusion: a Randomized Controlled Multi-center TrialStatus: Recruiting, Estimated PCD: 2024-12-20
Product
PlacebosProduct
DobutamineClinical trial
A Phase 3, Single-arm, Open-label Extension of the Vericiguat VALOR Study in Pediatric Participants With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction (VALOR EXT)Status: Not yet recruiting, Estimated PCD: 2032-04-15
Clinical trial
Treatment of Non-ischemic Dilated Cardiomyopathies by Intravenous Infusions of the Extracellular Vesicle-Enriched Secretome of Cardiovascular Progenitor CellsStatus: Recruiting, Estimated PCD: 2025-08-15
Clinical trial
Interest of Levosimendan Preconditioning for Cardiac Surgery Under CEC in Heart Failure Patients With Impaired Ejection FractionStatus: Recruiting, Estimated PCD: 2023-07-02
Product
LevosimendanClinical trial
Telmisartan Versus Enalapril in Heart Failure With Reduced Ejection Fraction Patients With Moderately Impaired Kidney Functions. "TRIUMF Trial"Status: Completed, Estimated PCD: 2022-07-30
Product
TelmisartanClinical trial
Randomized, Double-blind, Multiple Ascending Dose, Placebo-controlled, Safety, Tolerability, Efficacy, Pharmacokinetic (PK) and Pharmacodynamic (PD) Phase Ib/IIa Clinical Trial With AC01 in Patients With HFrEFStatus: Recruiting, Estimated PCD: 2025-06-30
Product
AC01Clinical trial
Factors Associated With Sub - Targeted Therapeutic Dose Of Renin - Angiotensin Blockage Among Chronic Heart Failure With Reduced Ejection Fraction PatientsStatus: Completed, Estimated PCD: 2020-12-31
Clinical trial
A Phase 2/3 Randomized, Placebo-Controlled, Double-blind, Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Vericiguat in Pediatric Participants With Heart Failure Due to Systemic Left Ventricular Systolic Dysfunction (VALOR)Status: Recruiting, Estimated PCD: 2030-04-30
Clinical trial
Lokelma for Maximisation of RAAS Inhibition in CKD Patients With Heart Failure; Randomised.Status: Recruiting, Estimated PCD: 2023-12-31
Product
LokelmaClinical trial
Administration of the SGLT-2 Inhibitor Dapagliflozin in the Patients With Amyloid Cardiomyopathy: a Pilot StudyStatus: Recruiting, Estimated PCD: 2025-01-01
Clinical trial
Effect of Empagliflozin on NT-Pro Brain Natriuretic Peptide in Heart Failure Patients With Reduced Ejection FractionStatus: Recruiting, Estimated PCD: 2024-06-15
Clinical trial
The Effects of Ferric Derisomaltose Administered Before Hospital Discharge in Stabilised Patients With Acute Heart Failure and Iron Deficiency on Exercise Capacity and Quality of Life: a Randomised, Parallel-group, Double-blind, Placebo Controlled Trial (COREVIVE-HFrEF)Status: Recruiting, Estimated PCD: 2024-08-01
Product
Ferric derisomaltoseClinical trial
Efficacy of Pulmonary Pressure Guided Therapy in Stable Outpatients With Advanced Heart Failure - A Randomized Controlled Clinical TrialStatus: Recruiting, Estimated PCD: 2025-12-31
Clinical trial
Hemodynamic Effects of Angiotensin Receptor Neprilysin Inhibition on Noninvasive Pressure-volume Analysis in Patients With Heart Failure With Reduced Ejection FractionStatus: Active (not recruiting), Estimated PCD: 2025-12-31
Product
Sacubitril-ValsartanClinical trial
EVOlocumab in Stable Heart Failure With Reduced Ejection Fraction of Ischemic Etiology: EVO-HF PilotStatus: Completed, Estimated PCD: 2021-06-30
Product
EvolocumabClinical trial
A Phase 2 Randomized, Double-blind, Placebo-controlled Study to Assess the Safety and Efficacy of JK07 in Adults With Chronic Heart Failure (RENEU-HF)Status: Recruiting, Estimated PCD: 2025-12-31