Organization
Reata
47 clinical trials
Clinical trial
A 52-Week, Multi-center, Double-blind, Randomized, Placebo-controlled Phase IIb Trial to Determine the Effects of Bardoxolone Methyl (RTA 402) on eGFR in Patients With Type 2 Diabetes and Chronic Kidney Disease With an eGFR of 20 - 45 mL/Min/1.73m2Status: Completed, Estimated PCD: 2010-05-31
Clinical trial
An Open-Label, Single-Center, Dose-Escalation, Phase 1 Study of the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RTA 408 in the Treatment of Patients With Advanced Solid TumorsStatus: Completed, Estimated PCD: 2015-10-01
Clinical trial
A Single Sequence, 2-Period, Open-label Crossover Study in Healthy Subjects to Determine the Effect of a Moderate CYP3A4 Inducer on the Pharmacokinetics of OmaveloxoloneStatus: Completed, Estimated PCD: 2023-08-30
Clinical trial
Safety and Clinical Activity of Nivatrotamab, an Anti GD2×CD3 Bispecific Antibody, in Relapsed/Recurrent Metastatic Small-cell Lung Cancer An Open-label, Single-arm, Multicenter, Phase 1/2 TrialStatus: Terminated, Estimated PCD: 2022-04-08
Clinical trial
Phase 1 Study to Investigate the Absorption, Metabolism, and Excretion of [14C] Omaveloxolone Following Single Oral Dose Administration in Healthy Male SubjectsStatus: Completed, Estimated PCD: 2019-05-31
Clinical trial
A Phase I Dose-finding and Pharmacokinetic Study of RTA 402 (CDDOMe) Administered Orally for 21 Days of a 28-day Cycle in Patients With Advanced Solid Tumors or Lymphoid MalignanciesStatus: Completed, Estimated PCD: 2008-12-01
Clinical trial
A Phase II Efficacy and Tolerability Study of RTA 744 in Breast Cancer Patients With Progression of Previously Irradiated Brain MetastasesStatus: Terminated, Estimated PCD: 2008-12-01
Clinical trial
Pilot Assessment of the Effects of Bardoxolone Methyl on Renal Perfusion, Systemic Haemodynamics and Cardiac Function in Patients With Chronic Kidney Disease and Type 2 DiabetesStatus: Withdrawn, Estimated PCD: 2012-11-30
Clinical trial
An Open-Label, Randomized, Dose-ranging Phase IIa Trial to Determine the Effects of RTA 402 (Bardoxolone Methyl) on Renal Function in Patients With Diabetic NephropathyStatus: Completed, Estimated PCD: 2009-05-31
Clinical trial
A Phase I Safety and Pharmacokinetic Study of Intravenous RTA 744 Injection in Patients With Recurrent, Progressive or Refractory Neoplastic MeningitisStatus: , Estimated PCD: 2008-12-01
Clinical trial
A Phase 2 Study of the Safety, Efficacy, and Pharmacodynamics of RTA 408 in the Treatment of Mitochondrial Myopathy (MOTOR)Status: Completed, Estimated PCD: 2017-11-02
Clinical trial
A Phase 2 Study of the Safety, Efficacy, and Pharmacodynamics of RTA 408 in the Treatment of Friedreich's Ataxia (MOXIe)Status: Active (not recruiting), Estimated PCD: 2019-10-31
Clinical trial
A Phase I Dose-finding and Pharmacokinetic Study of Intravenous RTA 744 Injection in Patients With Recurrent or Refractory Anaplastic Astrocytoma (AA), Anaplastic Oligodendroglioma (AO), Anaplastic Mixed Oligo-astrocytoma (AOA), Glioblastoma Multiforme (GBM) or Gliosarcoma (GS), With or Without Concurrent Treatment With Enzyme-inducing Anticonvulsant TherapyStatus: , Estimated PCD: 2008-12-01
Clinical trial
A Multiple-Dose, Open-Label Pharmakokinetic and Pharmacodynamic Study of Bardoxolone Methyl in Patients With Chronic Kidney Disease and Type 2 DiabetesStatus: Terminated, Estimated PCD: 2012-11-30
Clinical trial
A Phase 1 Study to Investigate the Absorption, Metabolism, and Excretion of [14C]-Bardoxolone Methyl Following a Single Oral Dose Administration in Healthy Male SubjectsStatus: Completed, Estimated PCD: 2011-12-31
Clinical trial
An Open-label, Multicenter, Dose-escalation, Phase 1b/2 Study of the Safety, Efficacy, Pharmacodynamics, and Pharmacokinetics of RTA 408 in Combination With Ipilimumab or Nivolumab in the Treatment of Patients With Unresectable or Metastatic MelanomaStatus: Completed, Estimated PCD: 2018-05-09
Clinical trial
A Multicenter, Phase II, Randomized, Open Label Trial of 2 Dose Levels of RTA 402 in Patients With Advanced Malignant MelanomaStatus:
Clinical trial
An Open-Label Study of the Effect of a Strong CYP3A4 Inhibitor (Itraconazole) on the Pharmacokinetics of Bardoxolone Methyl in Healthy VolunteersStatus: Completed, Estimated PCD: 2017-11-13
Clinical trial
A Single Dose, Open Label Pharmacokinetic Study of Omaveloxolone in Subjects With Mild, Moderate, or Severe Hepatic Impairment, or With Normal Hepatic FunctionStatus: Completed, Estimated PCD: 2020-01-27
Clinical trial
A Study of the Efficacy and Safety of Bardoxolone Methyl in Patients With Connective Tissue Disease-associated Pulmonary Arterial HypertensionStatus: Terminated, Estimated PCD: 2020-05-07
Clinical trial
A Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Doses of RTA 1701 in Healthy AdultsStatus: Completed, Estimated PCD: 2019-06-28
Clinical trial
A Phase 1, Open-Label Study to Evaluate the Pharmacokinetics and Safety of Local Administration of EXPAREL for Postsurgical Analgesia in Pediatric Subjects 12 to Less Than 17 Years of AgeStatus: Completed, Estimated PCD: 2019-02-12
Clinical trial
A Study of the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of RTA 901 in Healthy AdultsStatus: Completed, Estimated PCD: 2017-07-23
Clinical trial
An Extended Access Program to Assess Long-term Safety of Bardoxolone Methyl in Patients With Pulmonary HypertensionStatus: Terminated, Estimated PCD: 2020-09-30
Clinical trial
A Dose-Ranging Study of the Efficacy and Safety of Bardoxolone Methyl in Patients With Pulmonary HypertensionStatus: Completed, Estimated PCD: 2018-01-19
Clinical trial
A Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacodynamics, and Pharmacokinetics of RTA 408 Lotion in Healthy VolunteersStatus: Completed, Estimated PCD: 2014-04-01
Clinical trial
A Blinded Randomized Parallel Trial to Define the ECG Effects of Bardoxolone Methyl Using a Clinical and a Supratherapeutic Dose Compared to Placebo and Moxifloxacin (a Positive Control) in Healthy Men and Women: A Thorough ECG Trial.Status: Completed, Estimated PCD: 2012-11-30
Clinical trial
A Multicenter, Randomized, Dose-Ranging, Double-Masked, Placebo-Controlled Phase 2 Study Evaluating the Safety and Efficacy of RTA 408 Ophthalmic Suspension for the Treatment of Ocular Inflammation and Pain Following Ocular SurgeryStatus: Completed, Estimated PCD: 2014-09-30
Clinical trial
A Randomized, Double-Blind, Placebo- and Active-Controlled, 3-Way Crossover Study in Healthy Subjects to Determine the Effect of Omaveloxolone on QTc IntervalStatus: Completed, Estimated PCD: 2023-09-01
Clinical trial
A Multi-Center, Open-Label, Randomized, Parallel Group, Dose-Ranging, Pharmacodynamic Phase II Trial to Determine the Effects of Bardoxolone Methyl (RTA 402, Amorphous Dispersion) on eGFR in Patients With Type 2 Diabetes and Chronic Kidney Disease (eGFR 15-45 mL/Min/1.73m2)Status: Completed, Estimated PCD: 2010-12-31
Clinical trial
A Phase 1, Open-Label, 4-Part, Drug-Drug Interaction Study With Omaveloxolone in Healthy SubjectsStatus: Completed, Estimated PCD: 2019-08-18
Clinical trial
A Phase 2 Trial to Evaluate Safety, Tolerability, and Efficacy of Bardoxolone Methyl in Patients With Chronic Kidney Disease at Risk of Rapid ProgressionStatus: Completed, Estimated PCD: 2021-10-20
Clinical trial
A Multicenter, Randomized, Double-Masked, Vehicle-Controlled, Parallel-Group, Phase 2 Study of the Efficacy and Safety of RTA 408 For the Prevention of Corneal Endothelial Cell Loss in Patients Undergoing Cataract SurgeryStatus: Completed, Estimated PCD: 2015-02-28
Clinical trial
A Phase 2 Trial of the Safety and Efficacy of Bardoxolone Methyl in Patients With Rare Chronic Kidney DiseasesStatus: Completed, Estimated PCD: 2019-01-02
Clinical trial
A Single-Dose, Open-Label, Randomized, Food Effect and Blinded, Randomized, Dose Proportionality Study in Healthy Volunteers With Bardoxolone MethylStatus: Completed, Estimated PCD: 2011-12-31
Clinical trial
A Phase 2 Study to Evaluate the Safety and Efficacy of RTA 901 in Patients With Diabetic Peripheral Neuropathic Pain (DPNP)Status: Recruiting, Estimated PCD: 2026-08-01
Clinical trial
Randomized, Double-blind, Placebo-controlled, Multiple-dose, Dose-escalation Study to Assess the Safety, Tolerability, and Pharmacodynamics of RTA 402 (CDDO-Me) Administered Orally for 14 Days in Patients With Hepatic DysfunctionStatus: Terminated, Estimated PCD: 2007-11-30
Clinical trial
A Randomized, Double-blind, Vehicle-controlled, Parallel-group Phase 2 Study of the Efficacy, Safety, and Pharmacokinetics of RTA 408 Lotion in the Treatment of Patients at Risk for Radiation DermatitisStatus: Completed, Estimated PCD: 2015-04-30
Clinical trial
A Phase 2/3 Trial of the Efficacy and Safety of Bardoxolone Methyl in Patients With Alport SyndromeStatus: Completed, Estimated PCD: 2020-10-06
Clinical trial
A Randomized Phase I/II Study With Gemcitabine and RTA 402 or Gemcitabine and Placebo for Patients With Unresectable Pancreatic CancerStatus: Terminated, Estimated PCD: 2009-11-01
Clinical trial
Bardoxolone Methyl Evaluation in Patients With Chronic Kidney Disease and Type 2 Diabetes: the Occurrence of Renal Events (BEACON)Status: Terminated, Estimated PCD: 2012-10-31
Clinical trial
A Phase 1, Open-Label, Food Effect, And Dose Proportionality Study With Omaveloxolone In Healthy VolunteersStatus: Completed, Estimated PCD: 2018-11-20
Clinical trial
An Extended Access Program to Assess Long Term Safety of Bardoxolone Methyl in Patients With Chronic Kidney DiseaseStatus: Terminated, Estimated PCD: 2023-08-23
Clinical trial
A Phase 3 Trial of Bardoxolone Methyl in Patients With Autosomal Dominant Polycystic Kidney DiseaseStatus: Terminated, Estimated PCD: 2023-08-08