Organization
Lykos Therapeutics
28 clinical trials
Clinical trial
A Randomized, Double-Blind, Active Placebo-Controlled Phase 2 Pilot Study of MDMA-assisted Psychotherapy in People With Chronic, Treatment-Resistant Posttraumatic Stress Disorder (PTSD)Status: Completed, Estimated PCD: 2016-04-07
Clinical trial
Phase II Clinical Trial Testing the Safety and Efficacy of 3,4-Methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy in Subjects With Chronic Posttraumatic Stress DisorderStatus: Completed, Estimated PCD: 2008-05-02
Clinical trial
A First-in-human, Randomized, Double-blinded, Placebo-controlled, Single and Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, Bioavailability and Food-effects of EA1080 in Healthy Caucasian and Japanese Male VolunteersStatus: Completed, Estimated PCD: 2023-08-06
Clinical trial
An Open-Label Proof-of-Principle Study Testing the Use of an Additional MDMA-Assisted Therapy Session in People Who Relapsed After Participating in a Phase 2 Clinical Trial of MDMA-Assisted Therapy to Treat Chronic, Treatment-Resistant Posttraumatic Stress DisorderStatus: Completed, Estimated PCD: 2014-06-27
Clinical trial
An Open-Label Feasibility and Safety Study of MDMA-Assisted Group Therapy for the Treatment of Posttraumatic Stress Disorder in VeteransStatus: Withdrawn, Estimated PCD: 2024-12-01
Clinical trial
Evaluation of 3,4-methylenedioxymethamphetamine (MDMA) on Startle ResponseStatus: Completed, Estimated PCD: 2020-08-01
Clinical trial
A Randomized, Double-Blind, Dose Response Phase 2 Pilot Study of Manualized MDMA-Assisted Psychotherapy in Subjects With Chronic, Treatment-Resistant Posttraumatic Stress Disorder (PTSD)Status: Completed, Estimated PCD: 2015-12-03
Clinical trial
Exploring Mechanisms of Action of ±3,4-methylenedioxymethamphetamine (MDMA)- Assisted Psychotherapy for Posttraumatic Stress Disorder (PTSD)Status: Completed, Estimated PCD: 2015-08-03
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled Phase 2 Pilot Study of MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening IllnessStatus: Completed, Estimated PCD: 2017-04-25
Clinical trial
An Open-Label, Multi-Site Phase 2 Study of the Safety and Effect of Manualized MDMA-Assisted Therapy for the Treatment of Severe Posttraumatic Stress DisorderStatus: Completed, Estimated PCD: 2019-08-10
Clinical trial
A Phase 1/2 Open-Label Treatment Development Study of Methylenedioxymethamphetamine (MDMA)-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic Posttraumatic Stress Disorder (PTSD)Status: Completed, Estimated PCD: 2017-12-16
Clinical trial
A Placebo-controlled, Randomized, Blinded, Dose Finding Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic AdultsStatus: Completed, Estimated PCD: 2017-04-28
Clinical trial
Phase II Clinical Trial Testing the Safety and Efficacy of 3,4-Methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy in Subjects With Chronic Posttraumatic Stress DisorderStatus: Completed, Estimated PCD: 2008-05-02
Clinical trial
An Open-Label, Multi-Site Phase 2 Study of the Safety and Feasibility of MDMA-Assisted Psychotherapy for Eating DisordersStatus: Not yet recruiting, Estimated PCD: 2025-08-10
Clinical trial
A Phase 2, Open-Label, Randomized Comparative Effectiveness Study for MDMA-Assisted Psychotherapy in U.S. Veterans With Chronic PTSDStatus: Active (not recruiting), Estimated PCD: 2025-07-01
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled, Multi-Site Phase 3 Study of the Efficacy and Safety of Manualized MDMA-Assisted Psychotherapy for the Treatment of Posttraumatic Stress Disorder of Moderate or Greater SeverityStatus: Completed, Estimated PCD: 2022-10-30
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled, Multi-Site Phase 3 Study of the Efficacy and Safety of Manualized MDMA-Assisted Psychotherapy for the Treatment of Severe Posttraumatic Stress DisorderStatus: Completed, Estimated PCD: 2020-08-11
Clinical trial
A Phase 1, Single Center, Open Label, Randomized Sequence, 2-period Cross-over Study to Determine the Effect of Food on the Relative Bioavailability of 3,4-methylenedioxymethamphetamine (MDMA) Oral Formulation in Healthy VolunteersStatus: Completed, Estimated PCD: 2022-12-02
Clinical trial
A Phase 2, Open Label Study of the Safety and Effectiveness of MDMA-assisted Therapy for Participants With Posttraumatic Stress DisorderStatus: Withdrawn, Estimated PCD: 2023-08-01
Clinical trial
A Phase I, Open Label, Study of 3,4-Methylenedioxymethamphetamine (MDMA) Tolerability and Pharmacokinetics in Subjects With Moderate Hepatic Impairment Compared to Matched Control Subjects With Normal Hepatic FunctionStatus: Not yet recruiting, Estimated PCD: 2024-12-01
Clinical trial
An Open-Label, Multi-Site Phase 2 Study of the Safety and Effect of Manualized MDMA-Assisted Psychotherapy for the Treatment of Severe Posttraumatic Stress Disorder (Canada)Status: Completed, Estimated PCD: 2019-06-04
Clinical trial
A Multi-Site Open-Label Safety Extension Study of Manualized MDMA-Assisted Psychotherapy for the Treatment of Participants With Posttraumatic Stress DisorderStatus: Completed, Estimated PCD: 2023-11-01
Clinical trial
A Randomized, Double-Blind, Controlled Phase 2 Pilot Study of Manualized 3,4-methylenedioxymethamphetamine (MDMA)-Assisted Psychotherapy in 12 Subjects With Treatment-Resistant Posttraumatic Stress Disorder (PTSD) - CanadaStatus: Terminated, Estimated PCD: 2015-09-10
Clinical trial
Randomized, Triple-Blind, Phase 2 Pilot Study Comparing 3 Different Doses of MDMA in Conjunction With Manualized Therapy in 24 Veterans, Firefighters and Police Officers With Chronic Posttraumatic Stress Disorder (PTSD)Status: Completed, Estimated PCD: 2015-06-04
Clinical trial
A Phase 1 Placebo-Controlled, Double-Blind Crossover Study to Assess Psychological Effects of MDMA When Administered to Healthy VolunteersStatus: Completed, Estimated PCD: 2022-08-05
Clinical trial
MDMA-assisted Therapy in Twelve People With War and Terrorism-related Posttraumatic Stress Disorder (PTSD)Status: Terminated, Estimated PCD: 2009-03-01
Clinical trial
A Phase 1, Open-Label, Multi-Site Study to Assess Psychological Effects of MDMA-Assisted Psychotherapy When Administered to Healthy VolunteersStatus: Not yet recruiting, Estimated PCD: 2025-12-01
Clinical trial
Phase II Pilot Randomized Double-Blind Placebo-Controlled Study of 3,4-methylenedioxymethamphetamine (MDMA)Assisted Psychotherapy in Posttraumatic Stress Disorder (PTSD)- SwitzerlandStatus: Completed, Estimated PCD: 2009-09-02