Organization
King's College London
24 clinical trials
13 abstracts
Abstract
Observation vs. radiotherapy in primary mediastinal B-cell lymphoma patients with complete response to standard immunochemotherapy: The IELSG37 randomized trial.Org: Oncology Institute of Southern Switzerland, Institute of Oncology Research, Università della Svizzera italiana, Bellinzona, Switzerland, University of Southampton,
Abstract
Electronic frailty index predicts 30-day mortality from chemotherapy in breast, colorectal and lung cancer.Org: King's College London, Surrey Clinical Trials Unit, National Disease Registration Service, Data and Analytics; NHS England, University of Surrey, Guy's and St Thomas' NHS Foundation Trust,
Abstract
Efficacy and safety of dendrimer-enhanced (DEP) cabazitaxel (DEP CTX) in patients with advanced solid cancers in a phase 1/2 trial (P1/2).Org: King's College London, Imperial College, University College London Cancer Institute, University College London Hospital NHS Trust and Great Ormond Street Hospital, Kinghorn Cancer Centre,
Clinical trial
Role of the Oral Microbiome & Mucosal Immunity in COVID-19 Disease: Diagnostic/Prognostic Utility in South Asian PopulationsStatus: Recruiting, Estimated PCD: 2023-10-30
Clinical trial
Investigating the Effect of a Single-dose of Levetiracetam on Brain Function, Chemistry and Cognitive Performance in Psychosis RiskStatus: Not yet recruiting, Estimated PCD: 2026-02-01
Clinical trial
Extended-release Pharmacotherapy for Opioid Use Disorder (EXPO): Protocol for an Open-label Randomised Controlled Trial of Injectable Maintenance Buprenorphine With Personalised Psychosocial Intervention.Status: Completed, Estimated PCD: 2022-04-29
Clinical trial
A Multi-centre, Double-blind Randomised Controlled Trial to Compare Mirtazapine Versus Placebo Over 12 Weeks in Patients With Multimorbid Major Depression and Inflammatory Bowel Disease (MD-IBD): a Feasibility StudyStatus: Not yet recruiting, Estimated PCD: 2026-02-01
Clinical trial
Modulation of the Brain Excitatory/Inhibitory (E/I) Balance Through Neuronal Systems in Autism Spectrum Disorder (ASD)Status: Recruiting, Estimated PCD: 2025-03-31
Clinical trial
The Role of Inflammation in Brain and Cognitive Function in Mental DisordersStatus: Completed, Estimated PCD: 2023-06-15
Clinical trial
The Role of Glutamatergic Function in the Pathophysiology of Treatment-resistant SchizophreniaStatus: Recruiting, Estimated PCD: 2024-12-31
Clinical trial
Shifting Brain Excitation-Inhibition Balance Through the Endocannabinoid System in Men With Autism Spectrum Disorder (ASD) and in Healthy ControlsStatus: Completed, Estimated PCD: 2017-02-16
Clinical trial
A Prospective, Randomised Placebo Controlled Feasibility Trial of Faecal Microbiota Transplantation in CirrhosisStatus: Completed, Estimated PCD: 2019-09-30
Clinical trial
Lipid Ibuprofen Versus Standard of Care for Acute Hypoxemic Respiratory Failure Due to COVID-19: a Multicentre, Randomised, Controlled TrialStatus: Withdrawn, Estimated PCD: 2021-05-25
Clinical trial
Modulation of Serotonin Pathways Using Psilocybin in Adults With and Without Autism Spectrum Disorder (ASD)Status: Recruiting, Estimated PCD: 2025-09-01
Clinical trial
'Mind and Skin': A Prospective Cohort Study Evaluating the Impact of Inflammation, Itch and Sleep Disturbance on the Brain, Mental Health and Cognition, in Patients With Severe AtopyStatus: Recruiting, Estimated PCD: 2025-12-01
Clinical trial
Does Cannabidiol Attenuate the Acute Effects of ∆9-tetrahydrocannabinol Intoxication in Individuals Diagnosed With Schizophrenia? A Double-blind, Randomised, Placebo-controlled Experimental StudyStatus: Completed, Estimated PCD: 2023-07-07
Clinical trial
Pharmacokinetic Study of a Novel Lipid Formulation of Cannabidiol Compared to a Standard FormulationStatus: Completed, Estimated PCD: 2022-08-26
Clinical trial
Multimodal Longitudinal and Machine Learning-based Predictive Modelling to Understand the Development of Eating DisordersStatus: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
Synaptic Imaging and Brain Network Activity Following Ketamine in Treatment Resistant DepressionStatus: Recruiting, Estimated PCD: 2023-08-31
Clinical trial
A Feasibility Study of Mindfulness Training Transcranial Direct Current Stimulation (tDCS) in Adults With Overweight and Obesity.Status: Not yet recruiting, Estimated PCD: 2024-07-01
Clinical trial
Effect of Benzodiazepine on Corticolimbic Activation, GABA and Glutamate in Subjects at Clinical High Risk of PsychosisStatus: Completed, Estimated PCD: 2023-03-24
Clinical trial
Investigating Glutamate and Opioid Mechanisms of Antidepressant Response to KetamineStatus: Completed, Estimated PCD: 2023-02-13
Clinical trial
A Multi-national, Prospective Mixed Methods Study of the Effectiveness of Naloxone (Including Intranasal Nyxoid) Administration by Lay People in Reversing Opioid OverdoseStatus: Recruiting, Estimated PCD: 2023-12-30
Clinical trial
A First in Human Feasibility Study of T Regulatory Cells (TR004) for Inflammatory Bowel Disease Using (ex Vivo) Treg ExpansionStatus: Recruiting, Estimated PCD: 2024-03-31
Clinical trial
Prospective Randomised Marker-based Trial to Assess the Clinical Utility and Safety of Biomarker-guided Immunosuppression Withdrawal in Liver TransplantationStatus: Terminated, Estimated PCD: 2021-12-31
Abstract
Phase 2 study of ISA101b (peltopepimut-S) and cemiplimab in patients with advanced HPV16+ oropharyngeal cancer who failed anti-PD1 therapy.Org: King's College London, ISA Pharmaceuticals B.V., Gustave Roussy Département d'Organisation du Parcours Patient, Centre Leon Bérard, H. Lee Moffitt Cancer Center & Research Institute,
Abstract
Development of a novel immune-related toxicity grading system for predicting outcomes in patients with solid tumours treated with immune checkpoint inhibitors (ICI).Org: King's College London, Guy's and St. Thomas' NHS Foundation Trust, Guy's and St. Thomas' Hospital, Guys' and St. Thomas' NHS Foundation Trust,
Abstract
REFINE-Lung: A multicentre phase III study to determine the optimal frequency of pembrolizumab in non-small cell lung cancer utilising a novel multi-arm design.Org: Imperial College London, MRC Clinical Trials Unit UCL, Christie Hospital NHS Foundation Trust and the University of Manchester, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, University of Liverpool,
Abstract
SMALL: Open surgery versus minimally invasive vacuum-assisted excision for small screen-detected breast cancer—A UK phase III randomised multi-centre trial.Org: Queen's University Belfast, University of Cambridge, University of Oxford, Western General Hospital, University of Birmingham,
Abstract
Circulating chromatin conformation signatures to enhance PSA positive predictive value and overall accuracy for prostate cancer detection.Org: Oxford BioDynamics Plc, Oxford BioDynmics Plc, Oxford Biodynamics Limited, King's College London, Imperial College London,
Abstract
Novel machine learning algorithm to predict response to immunotherapy in patients with small cell and non-small cell lung cancer.Org: GKT School of Medicine, King's College London, Curenetics Ltd, Imperial College London, School of Physics, Engineering & Computer Science,
Abstract
Identification of novel phosphoproteomic biomarkers in patients with advanced hepatocellular carcinoma (HCC).Org: King's College London, Kinomica Limited, King's College Hospital NHS Foundation, Institute of Liver Studies, King’s College Hospital, Institute of Liver Studies,
Clinical trial
Exploring Barriers and Facilitators to Uptake of the MMR Vaccine Among Healthcare Workers at King's College Hospital NHS Foundation TrustStatus: Not yet recruiting, Estimated PCD: 2024-10-01
Abstract
ADALIMUMAB TREATMENT EFFECTS ON RADIOGRAPHIC PROGRESSION OF JOINT DISEASE IN PATIENTS WITH PSORIATIC ARTHRITIS: RESULTS FROM ADEPTOrg: Swedish Medical Center, University of Washington School of Medicine, Southwest Medical Imaging, Department of Medicine, University of Alberta, Alberta, Canada, University of Toronto,
Abstract
ACHIEVEMENT OF NICE QUALITY STANDARDS FOR PATIENTS WITH NEW PRESENTATION OF INFLAMMATORY ARTHRITIS: RESULTS FROM THE UK NATIONAL CLINICAL AUDIT FOR RHEUMATOID AND EARLY INFLAMMATORY ARTHRITIS Org: Portsmouth Hospitals NHS Trust, Portsmouth, Pennine MSK Partnership, Oldham, King's College London, British Society for Rheumatology, London, Lancashire Care NHS Foundation Trust, Preston,
Abstract
AN INVESTIGATION OF JOINT INFLAMMATION DEFINED BY COMPREHENSIVE ULTRASOUND ASSESSMENT AND PAIN SENSITISATION IN PATIENTS WITH ACTIVE RAOrg: King's College Hospital NHS Foundation, King's College London, King's College London, Psychology and Inflammation Biology,
Clinical trial
PROMISE Trial: A PROspective Randomised Double-blind Parallel Group Placebo-controlled Multicentre Trial of Faecal MIcrobiota tranSplantation to Improve the Primary outcomE (First Hospitalisation Due to Infection) in Patients With Cirrhosis Over 24 MonthsStatus: Recruiting, Estimated PCD: 2026-11-30