Organization
Children's Hospital of Philadelphia
36 clinical trials
18 abstracts
Abstract
Feasibility of the Poverty-Targeted Pediatric Cancer Resource Equity (PediCARE) intervention.Org: Children's Hospital of Philadelphia, DFCI/PCC Fellowship Program - Attendings, Dana-Farber Cancer Institute, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, University of Alabama at Birmingham,
Abstract
Feasibility and acceptability of social determinants of health data collection in the context of a Children’s Oncology Group trial.Org: Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, UCSF Benioff Children's Hospital, Children's Hospital of Philadelphia, Children's Oncology Group Statistics and Data Center, University of Florida, University of Minnesota,
Abstract
A multicenter cooperative group study of late effects after high-risk neuroblastoma: COG ALTE15N2—LEAHRN study.Org: Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Institute for Cancer Outcomes and Survivorship, University of Alabama at Birmingham, St. Jude Children's Research Hospital, Children's Oncology Group Statistics and Data Center, University of Florida, Children's Hospital Los Angeles Department of Pediatrics,
Abstract
A phase 3 trial of inotuzumab ozogamicin for high-risk B-ALL: Second safety phase results from Children’s Oncology Group AALL1732.Org: Cincinnati Children's Hospital Medical Center, Children's Hospital of Philadelphia, University of Florida Department of Biostatistics, UCSF Benioff Children's Hospital Oakland, Loyola University Medical Center,
Abstract
Impact of an objective scoring system on initiation of therapy in patients with International Neuroblastoma Risk Group Staging System (INRGSS) stage MS neuroblastoma: A report from the Children’s Oncology Group.Org: Children's Hospital Colorado, Aurora, CO, Children's Oncology Group Statistics and Data Center, University of Florida, Baylor College of Medicine, Children's Hospital of Philadelphia, Roswell Park Cancer Institute Department of Cancer Prevention and Population Sciences,
Abstract
A pilot study of post-consolidation chemoimmunotherapy for high-risk neuroblastoma (ANBL19P1): A report from the Children’s Oncology Group.Org: University of Chicago Medical Center, Chicago, IL, Children's Oncology Group Statistics and Data Center, University of Florida, University of Florida-Health Cancer Center, Orlando Health, Orlando, FL, Children's Oncology Group Statistics & Data Center, Department of Biostatistics & Data Science,
Abstract
CINSARC score use in pediatric non-rhabdomyosarcoma soft tissue sarcoma (NRSTS) in the Children’s Oncology Group (COG) studies ARST0332 and ARST1321.Org: Children's Hospital of Philadelphia, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, Children's Oncology Group Statistics and Data Center, University of Florida, Massachusetts General Hospital, Seattle Children's Hospital,
Abstract
Vincristine (VCR) pharmacokinetics (PK) in infants dosed using a body surface area (BSA) banded dosing table and in older children dosed based on BSA: A pediatric early phase clinical trial network study (PEPN22P1).Org: Children's Hospital Colorado, Aurora, CO, Children's Hospital of Philadelphia, Children's Oncology Group Statistics and Data Center, University of Florida, Texas Children's Cancer and Hematology Center, Institute for Clinical and Translational Research, Baylor College of Medicine,
Abstract
Evolution of tisagenlecleucel use for the treatment of pediatric and young adult relapsed/refractory (r/r) B-cell acute lymphoblastic leukemia (B-ALL): Center for International Blood & Marrow Transplant Research (CIBMTR) registry results.Org: Dana-Farber Cancer Institute, Boston Children's Hospital Cancer and Blood Disorders Center, Memorial Sloan Kettering Cancer Center, University of Colorado Denver, Children's Mercy Hospital,
Abstract
SARC037: Phase II results of trabectedin given as a 1-hour (h) infusion in combination with low dose irinotecan in patients (pts) with relapsed/refractory Ewing sarcoma (ES).Org: Children's Hospital of Philadelphia, Mayo Clinic, Department of Population Health Sciences, Weill Cornell Medicine, Children’s Hospital Los Angeles,
Abstract
Prospective evaluation of pre-treatment ctDNA burden in localized osteosarcoma to identify patients with inferior outcomes: A report from the LEOPARD study.Org: Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Massachusetts General Hospital, Aflac Cancer Center/Children's Healthcare of Atlanta, Children's Hospital & Clinics Minnesota, Cedars-Sinai Medical Center,
Abstract
Deciphering pediatric low-grade glioma trajectories: Deep learning–based volumetrics for patients under surveillance.Org: Brigham and Women's Hospital, Division of Neuroradiology, Perelman School of Medicine, University of Pennsylvania, Department of Radiology,
Clinical trial
Evaluation of 18F-Fluciclovine PET-MRI as a Biomarker of Response in Pediatric and Young Adult Patients With Low Grade Gliomas (LGG)Status: Not yet recruiting, Estimated PCD: 2025-09-01
Clinical trial
A Feasibility Study of Xofluza Treatment of Influenza in Pediatric Transplant Recipients, Waitlisted Subjects and Household Members After Early Infection Alerting Using Wearable DevicesStatus: Recruiting, Estimated PCD: 2024-05-31
Clinical trial
Clinical Effectiveness of Contrast-Enhanced Ultrasound in the Evaluation of Blunt Abdominal Trauma in Young ChildrenStatus: Active (not recruiting), Estimated PCD: 2024-12-01
Clinical trial
Rifampin to Reduce Elevated Levels of Blood and Urine Calcium in Patients With Inactivating Mutations in the CYP24A1 GeneStatus: Recruiting, Estimated PCD: 2026-12-01
Clinical trial
Efficacy of Dupilumab on Facilitated Food Introduction in Eosinophilic EsophagitisStatus: Active (not recruiting), Estimated PCD: 2024-10-01
Clinical trial
Quantitative Analysis of Selected PEG 3350 Components and Metabolites in Children's Plasma and UrineStatus: Recruiting, Estimated PCD: 2024-06-01
Clinical trial
Occipital Nerve Blocks for Acute Treatment of Pediatric MigraineStatus: Completed, Estimated PCD: 2023-03-10
Clinical trial
Evaluation of Bowel Perfusion With Contrast-Enhanced Ultrasound in Necrotizing EnterocolitisStatus: Recruiting, Estimated PCD: 2024-06-12
Abstract
Interpretable artificial intelligence-based analysis for morphologic classification of neuroblastic tumors.Org: University of Chicago Pritzker School of Medicine, Children's Hospital of Philadelphia, University of Chicago, Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, Stanford University Medical Center, Stanford, CA,
Clinical trial
A Phase I Trial of Cabozantinib (XL184) in Combination With High-dose Ifosfamide in Adults and Children With Relapsed/Refractory Ewing Sarcoma and OsteosarcomaStatus: Recruiting, Estimated PCD: 2027-11-01
Clinical trial
Head Injury Treatment With Healthy and Advanced Dietary Supplements (HIT HEADS): A Randomized, Placebo-controlled, Double-blinded, Therapeutic Exploratory Clinical Trial of Branched Chain Amino Acids (BCAA's) in the Treatment of ConcussionStatus: Completed, Estimated PCD: 2023-01-01
Clinical trial
Lurbinectedin in FET-Fusion Tumors (LIFFT)Status: Recruiting, Estimated PCD: 2026-07-30
Clinical trial
Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in SepsisStatus: Recruiting, Estimated PCD: 2025-05-31
Clinical trial
Contrast Enhanced Ultrasound (CEUS) Detection of Microvascular Perfusion Impairment in COVID-19 Pediatric PatientsStatus: Completed, Estimated PCD: 2021-09-17
Clinical trial
Proton Pump Inhibitors (PPI) and Fat Absorption in Subjects With Cystic Fibrosis (CF) and Exocrine Pancreatic Insufficiency (EPI)Status: Completed, Estimated PCD: 2022-11-02
Clinical trial
Contrast Enhanced Ultrasonography for Blunt Abdominal Trauma Imaging in ChildrenStatus: Recruiting, Estimated PCD: 2024-12-31
Clinical trial
Calculating Wall Shear Stress in Pulmonary Veins of Infants Using Cardiac Magnetic Resonance Imaging: A Pilot StudyStatus: Not yet recruiting, Estimated PCD: 2025-09-01
Clinical trial
Phase 1/2 Study Evaluating the Safety and Efficacy of Gene Therapy Employing Lentiviral Vector ALS20-transduced Hematopoietic Progenitor Cells in Subjects With Transfusion-dependent-thalassemiaStatus: Not yet recruiting, Estimated PCD: 2027-12-31
Clinical trial
Reduced Intensity Conditioning (RIC) Regimen for Patients With Non-malignant DisordersStatus: Active (not recruiting), Estimated PCD: 2025-12-01
Clinical trial
Dose Escalation Pharmacokinetic Study of Intranasal Atomized Dexmedetomidine in Pediatric Patients With Congenital Heart DiseaseStatus: Terminated, Estimated PCD: 2021-10-12
Clinical trial
Expanded Access Use of 18F-L-Fluoro-DOPA PET/CT Scan Localization of Focal Pancreatic Lesions in Subjects With Hyperinsulinemic HypoglycemiaStatus:
Clinical trial
The Utility of pGz in Primary Mitochondrial DisordersStatus: Recruiting, Estimated PCD: 2024-10-01
Clinical trial
Use of Intraoperative Contrast-enhanced Ultrasound to Evaluate Femoral Head Perfusion in Infants With Developmental Dysplasia of the Hip at the Time of Surgical ReductionStatus: Recruiting, Estimated PCD: 2025-04-01
Clinical trial
A Pilot Study in the Treatment of BK Virus Infection With Cytotoxic T Cells in Immunocompromised Transplant PatientsStatus: Recruiting, Estimated PCD: 2025-01-30
Clinical trial
Reverse Transcriptase Inhibitors in Aicardi Goutières SyndromeStatus: Not yet recruiting, Estimated PCD: 2028-12-01
Clinical trial
Opioid-Free Versus Transitional Anesthetic With Opioids From TonsillectomyStatus: Recruiting, Estimated PCD: 2023-10-30
Clinical trial
Randomized Trial of Maternal Progesterone Therapy to Improve Neurodevelopmental Outcomes in Infants With Congenital Heart DiseaseStatus: Completed, Estimated PCD: 2021-11-01
Clinical trial
RH Genotype Matched Red Cells for Patients With Sickle Cell Disease and Anti-DStatus: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
Improved Diagnosis and Prognostication of Hypoxic Ischemic Injury in Neonates and Infants Using Contrast-Enhanced UltrasoundStatus: Recruiting, Estimated PCD: 2024-09-01
Clinical trial
Acute Imposition of Fontan Physiology in The Single Ventricle Patient: Effects on Fibrosis, Function and Drug InterventionStatus: Recruiting, Estimated PCD: 2025-03-30
Clinical trial
Evaluation of the Enteroinsular Axis in Cystic FibrosisStatus: Recruiting, Estimated PCD: 2025-07-01
Clinical trial
A Pilot Investigator Initiated Study to Evaluate the Safety, Tolerability and Efficacy of Elamipretide in the Treatment of Advanced Symptoms of Friedreich Ataxia (FRDA)Status: Active (not recruiting), Estimated PCD: 2024-07-31
Clinical trial
Larotrectinib to Enhance RAI Avidity in Patients With Differentiated Thyroid Cancer Harboring NTRK FusionsStatus: Recruiting, Estimated PCD: 2024-10-01
Clinical trial
Evaluation of 18F-Fluciclovine PET-MRI to Differentiate Tumor Progression From Post-treatment Changes in Pediatric High-grade Glioma (HGG)Status: Recruiting, Estimated PCD: 2025-12-01
Clinical trial
RH Genotype Matched Red Cell Transfusions for Patients With Sickle Cell DiseaseStatus: Recruiting, Estimated PCD: 2029-04-01
Clinical trial
Melatonin Effects on Sleep and Circadian Rhythm in Youth and Young Adults With At-risk SymptomsStatus: Completed, Estimated PCD: 2023-04-07
Abstract
Hematology/oncology program director perspectives on recruitment and inclusion of a diverse workforce.Org: University of California San Francisco, University of Minnesota Masonic Cancer Center, Minneapolis, MN, Dana-Farber/Brigham and Women's Cancer Center, San Francisco VA Medical Center, University of Florida Health Shands Hospital,
Abstract
SARC037: Results of phase I study of trabectedin given as a 1-hour (h) infusion in combination with low dose irinotecan in relapsed/refractory Ewing sarcoma (ES).Org: Children's Hospital of Philadelphia, Weill Cornell Medicine and NewYork-Presbyterian Hospital, New York, NY, Pediatric Oncology Branch, Clinical Center National Institutes of Health, Clinical Center National Institutes of Health, NIH / NCI,
Abstract
Physical and emotional quality of life in children with B-acute lymphoblastic leukemia randomized to every 4- vs. 12-week vincristine/dexamethasone during maintenance: Children’s Oncology Group AALL0932.Org: Children's Oncology Group Data Center, Yale University Hematology/Oncology, St. Jude Children's Research Hospital, Children's National Medical Center, Washington, DC, University of Texas Southwestern Medical Center,
Abstract
Congenital anomalies and health outcomes among survivors of childhood cancer: A report from the Childhood Cancer Survivor Study.Org: Baylor College of Medicine, Children's Hospital of Philadelphia, National Cancer Institute, Vilnius, Lithuania, Duke University Trent Center for Bioethics Humanities and History of Medicine, Durham, NC, University of Alabama at Birmingham School of Medicine,
Abstract
The spectrum of RAF1 fusion positive solid tumors in children and young adults.Org: Children's Hospital of Philadelphia, University of California at Los Angeles,
Clinical trial
Selpercatinib to Enhance RAI Avidity in Children, Adolescents, and Young Adults With Newly Diagnosed Differentiated Thyroid Cancers Harboring RET FusionsStatus: Not yet recruiting, Estimated PCD: 2030-08-01