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Product

VX-548

Aliases
Suzetrigine, VX-548 Placebo

15 clinical trials

3 indications

Indication
Pain
Indication
Diabetic Peripheral Neuropathy
Indication
Lumbosacral Radiculopathy
Clinical trial
A Phase 3, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty
Status: Completed, Estimated PCD: 2023-08-25
Clinical trial
A Phase 1, Randomized, Open-label, Crossover Study Evaluating the Effects of Food on the Pharmacokinetics of VX-548 in Healthy Adults
Status: Completed, Estimated PCD: 2023-10-30
Clinical trial
A Phase 1, Open-label, Randomized, Crossover Study to Evaluate the Relative Bioavailability and Food Effect of a New Tablet Formulation of VX-548 in Healthy Adult Subjects
Status: Completed, Estimated PCD: 2022-09-17
Clinical trial
A Phase 1, Open-label Study to Evaluate the Pharmacokinetics and Safety of Multiple Doses of VX-548 in Subjects With Mild or Moderate Hepatic Impairment and in Matched Healthy Subjects
Status: Completed, Estimated PCD: 2023-07-24
Clinical trial
A Phase 2, Randomized, Double-blind, Active-controlled, Dose-ranging, Parallel-design Study of the Efficacy and Safety of VX-548 in Subjects With Painful Diabetic Peripheral Neuropathy
Status: Completed, Estimated PCD: 2023-10-12
Clinical trial
A Phase 3, Single-arm Study Evaluating the Safety and Effectiveness of VX-548 for Acute Pain
Status: Completed, Estimated PCD: 2023-12-12
Clinical trial
A Phase 3, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
Status: Completed, Estimated PCD: 2023-12-15
Clinical trial
A Phase 1, Open-label Drug-drug Interaction Study to Evaluate the Effects of Omeprazole and Rifampin on the Pharmacokinetics of VX-548 in Healthy Subjects
Status: Completed, Estimated PCD: 2023-06-08
Clinical trial
A Phase 1, Randomized, Double-blind, Placebo- and Active-controlled, Thorough QT/QTc Study of VX-548 in Healthy Subjects
Status: Completed, Estimated PCD: 2023-06-12
Clinical trial
A Phase 1, Open-label Study to Evaluate Pharmacokinetic Drug-drug Interactions Between VX-548 and Midazolam and Digoxin in Healthy Subjects
Status: Completed, Estimated PCD: 2023-04-16
Clinical trial
A Phase 2, Randomized, Double-blind, Placebo-controlled, Parallel-design Study of the Efficacy and Safety of VX-548 in Subjects With Painful Lumbosacral Radiculopathy
Status: Recruiting, Estimated PCD: 2025-04-01
Clinical trial
A Phase 1, Open-label Study to Evaluate the Pharmacokinetics and Safety of Single Doses of VX-548 in Subjects With Severe or Moderate Renal Impairment and in Matched Healthy Subjects
Status: Completed, Estimated PCD: 2024-03-30
Clinical trial
A Phase 2, Randomized, Double-blind, Placebo-controlled, Multi-dose Study Evaluating the Efficacy and Safety of VX-548 for Acute Pain After an Abdominoplasty
Status: Completed, Estimated PCD: 2021-12-05
Clinical trial
A Phase 2, Randomized, Double-blind, Placebo-controlled, Dose-ranging, Study Evaluating the Efficacy and Safety of VX-548 for Acute Pain After a Bunionectomy
Status: Completed, Estimated PCD: 2022-02-17
Clinical trial
A Phase 1, Randomized, Double-blind, Placebo-controlled, Parallel Study Evaluating the Effects of Single Doses of NaV1.8 Inhibitors on C-Nociceptor Action Potentials in Healthy Adults
Status: Not yet recruiting, Estimated PCD: 2025-09-01