Product
Obeticholic acid
Aliases
6alpha-ethylchenodeoxycholic acid (6-ECDCA), INT-747, Obeticholic Acid, OCA (1 other aliases)
8 clinical trials
12 indications
Indication
Primary Biliary CholangitisIndication
PruritusIndication
CirrhosisIndication
Non-alcoholic SteatohepatitisIndication
Familial Partial LipodystrophyIndication
Familial Adenomatous PolyposisIndication
Colorectal cancerIndication
Duodenal CarcinomaIndication
Barrett's EsophagusIndication
Primary Bile Acid MalabsorptionIndication
Bile Acid MalabsorptionIndication
Chronic DiarrhoeaClinical trial
A Phase 2, Double-Blind, Randomized, Parallel Group Study Evaluating the Efficacy, Safety, and Tolerability of Obeticholic Acid Administered in Combination With Bezafibrate in Subjects With Primary Biliary Cholangitis Who Had an Inadequate Response or Who Were Unable to Tolerate Ursodeoxycholic AcidStatus: Active (not recruiting), Estimated PCD: 2025-10-01
Clinical trial
A Phase 2a, Double-Blind, Randomized, Active Controlled, Parallel Group Study Evaluating the Efficacy, Safety, and Tolerability of Bezafibrate Administered in Combination With Obeticholic Acid in Subjects With Primary Biliary CholangitisStatus: Active (not recruiting), Estimated PCD: 2024-08-01
Clinical trial
A Two-part, Phase 1, Open-label, Randomized, Parallel-arm, Fixed Sequence, Drug-drug Interaction Study to Investigate the Effect of Linerixibat on Plasma Concentrations of Obeticholic Acid and Conjugates in Healthy Adult ParticipantsStatus: Completed, Estimated PCD: 2022-05-31
Clinical trial
A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Obeticholic Acid in Subjects With Compensated Cirrhosis Due to Nonalcoholic SteatohepatitisStatus: Completed, Estimated PCD: 2022-09-08
Clinical trial
Phase 2 Study of Obeticholic Acid for Lipodystrophy PatientsStatus: Completed, Estimated PCD: 2022-10-01
Clinical trial
A Phase IIa, Placebo-Controlled, Randomized Study of Daily Obeticholic Acid (OCA) to Reduce Intestinal Polyp Burden in Familial Adenomatous Polyposis (FAP)Status: Recruiting, Estimated PCD: 2026-01-31
Clinical trial
Obeticholic Acid for Prevention in Barrett's EsophagusStatus: Recruiting, Estimated PCD: 2025-09-29
Clinical trial
Obeticholic Acid Treatment in Patients With Bile Acid Diarrhoea: an Open-label, Pilot Study of Mechanisms, Safety and Symptom Response.Status: Completed, Estimated PCD: 2014-01-01