Target

thymidylate synthase

25 products, 19 indications

Indications

metastatic non-small cell lung cancer (5 products)

NSCLC (5 products)

advanced non-squamous NSCLC (3 products)

EGFRm+ NSCLC with CNS metastasis (3 products)

EGFR ex20ins-mutant NSCLC (3 products)

KRAS G12C-mutated solid tumors (1 products)

NSCLC with leptomeningeal metastases (1 products)

EGFR-mutated, c-Met overexpressing NSCLC (1 products)

stage 4 non-squamous non-small cell lung cancer (1 products)

Unresectable stage III non-small cell lung cancer (1 products)

Non-Small Cell Lung Cancer (1 products)

unresectable stage 3 NSCLC (1 products)

unresectable stage IIIA/IIIB NSCLC (1 products)

Locally advanced non-small cell lung cancer (1 products)

Advanced NSCLC with EGFR mutation (1 products)

Platinum-resistant recurrent ovarian carcinoma (1 products)

Ovarian Cancer (1 products)

HER2+ metastatic gastric cancer (1 products)

recurrent or metastatic pancreatic cancer (1 products)

2 drugs

3 abstracts

Abstract

Trastuzumab deruxtecan (T-DXd) vs physician’s choice of chemotherapy (TPC) in patients (pts) with hormone receptor-positive (HR+), human epidermal growth factor receptor 2 (HER2)-low or HER2-ultralow metastatic breast cancer (mBC) with prior endocrine therapy (ET): Primary results from DESTINY-Breast06 (DB-06).

Org: University of Milan and European Institute of Oncology, IRCCS, Fudan University Shanghai Cancer Center, Division of Medical Oncology, National Cancer Centre of Singapore, National Cancer Center Hospital East, Kashiwa, Japan, Latin American Cooperative Oncology Group (LACOG),

Abstract

Upfront palliative resection of primary tumor versus no resection in patients with synchronous metastatic colorectal cancer: The randomized phase 3 CAIRO4 study of the Dutch Colorectal Cancer Group (DCCG).

Org: University Medical Center Utrecht, Utrecht University, Netherlands Comprehensive Cancer Organisation (IKNL), Erasmus Medical Center, Amsterdam University Medical Centers,

Abstract

Patients with endometrial cancer: Expectations and preferences towards therapy and quality of life—First results of an international survey (NOGGO, ENGOT, GCIG - IMPROVE/EXPRESSION XI).

Org: Charite-Universitätsmedizin Berlin, Department of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Berlin, Germany, Department of Gynecology with Center for Oncological Surgery, Campus Virchow Klinikum, Charité-Universitätsmedizin Berlin, Berlin, Germany, Campus Virchow Klinikum, Charité - University Medicine of Berlin, Institute of Biometry and Clinical Epidemiology,

Drug

Pemetrexed

Drug

S-1