Abstract
Accrual of adolescents and young adults (AYA) into cancer clinical trials in Canada.
Author
person
Mariam Jafri
Canadian Cancer Trials Group, Kingston, ON, Canada
info_outline
Mariam Jafri, Corey Willman, Alison May Urton, Jan-Willem Henning, Lesleigh S. Abbott, Kelly Davison, Mohamed A. Akra, Lesley Seymour, Janet Ellen Dancey, Annette E. Hay
Full text
Authors
person
Mariam Jafri
Canadian Cancer Trials Group, Kingston, ON, Canada
info_outline
Mariam Jafri, Corey Willman, Alison May Urton, Jan-Willem Henning, Lesleigh S. Abbott, Kelly Davison, Mohamed A. Akra, Lesley Seymour, Janet Ellen Dancey, Annette E. Hay
Organizations
Canadian Cancer Trials Group, Kingston, ON, Canada, University of Calgary, Calgary, AB, Canada, The Children's Hospital of Eastern Ontario, Ottawa, ON, Canada, Research Institute of McGill University Health Centre, Montreal, QC, Canada, CancerCare Manitoba, Winnipeg, MB, Canada, Canadian Cancer Trials Group, Queen's University, Kingston, ON, Canada, Queen's University, Kingston, ON, Canada
Abstract Disclosures
Research Funding
Other
Canadian Cancer Society
Background:
Historically, accrual rates of AYA (aged 16-39) to cancer clinical trials have been low. This is suggested to contribute to lesser improvements in their outcomes compared with older and younger populations. We sought to describe the impact of collaborative initiatives launched by the Canadian Cancer Trials Group (CCTG), NCTN and C17 to address this.
Methods:
All CCTG trials open to accrual from 01/01/2004 to 31/12/2022 were evaluated. Trials with eligibility criteria limited to age > 39, or for which CCTG did not have access to individual patient data on age, were excluded. Accrual rates were assessed by age (<30, 30-39, >40 yrs), cancer type, and compared with 2022 Canadian Cancer Society (CCS) prevalence data.
Results:
379 studies were open to accrual. 21 trials were excluded as they had no patients aged 16-39 within their inclusion criteria. 2 trials were excluded as they were either COVID related or a trial sub-study. 230 trials were excluded owing to patient age data being unavailable to CCTG. 126 CCTG and NCTN led trials were included. They involved the following disease sites: brain (3), breast (13), GI (12), GU (11), gynecology (6), head & neck (3), hematology (10), lung (11), melanoma (4), sarcoma (2) novel investigational agents (45) and symptom control (6) – the latter two spanned multiple tumor types. Patients aged 16-18 were excluded from many trials limiting accrual opportunities in this subgroup. AYA patients were recruited into trials at a higher level than expected by prevalence data except for brain, lung and head & neck patients. This may be due to younger, fitter patients being recruited onto trials. GU trials, hematology and sarcoma trials recruited better than expected as there were trials geared to diseases common in younger individuals (e.g. germ cell cancers) and incorporating intensive therapy e.g. stem cell transplantation in lymphoma. 3.5% of patients accrued on trials were <40 in 2004-2013 c.f. 8.7% of patients 2014-2022.
Conclusions:
Limited data is available on AYA aged 16-18 due to trial entry criteria. Currently, most CCTG trials include patients aged ≥14. Trial accrual in the AYA population was higher than predicted by CCS data indicating that clinical trials are acceptable to AYA patients. This supports ongoing efforts to improve trial access to AYA.
Disease
Patients accrued to trials
25-year prevalence (diagnosed since 1993)* *CCS Jan 2018
<30
%
30-39
%
≥40
%
Total
15-29
%
30-39
%
≥40
%
Total
Brain
0
0
2
2
113
98
115
2475
1.4
1930
2.7
7885
95.5
13385
Breast
12
0.7
128
7.5
1569
92
1709
335
0.1
4215
1.3
325255
98.6
329805
GI
8
0.5
40
2.6
1482
97
1530
1030
0.5
2325
1.1
217755
98.5
221140
GU
43
3.8
50
4.3
1046
92
1139
5735
1.3
6180
1.4
444385
97.9
453830
Head & Neck
0
0
3
0.7
421
99
424
390
0.8
870
1.8
47250
99.1
47700
Hematology
25
10.3
27
11
184
76.3
241
8370
5.4
8065
5.2
153200
98.6
155445
Lung
1
0.1
9
0.8
1176
99.7
1180
125
0.2
330
0.5
66670
99.3
67155
Sarcoma
5
45.5
1
9
5
45.5
11
-
-
-
-
-
-
-
All
216
516
10408
11139
22740
42850
1501575
1573960
6 organizations
1 drug
Organization
Canadian Cancer Trials GroupOrganization
University of CalgaryOrganization
The Children's Hospital of Eastern OntarioOrganization
CancerCare ManitobaOrganization
Queen's University, Belfast