Optimizing Reversal of HIV Latency With Combination Therapy (Pyrimethamine, Lenalidomide, Panobinostat)

2024-511192-15-00

The ORBIT trial is part of a worldwide search for a functional cure of HIV. One such cure strategy aims to reverse HIV in the reservoir from latency by increasing cell-associated HIV-RNA, which will lead to increased antigen presentation, trigger immune recognition, and facilitate the elimination of reservoir cells (so-called 'shock and kill' approach to HIV cure). Participants of the trial are adults with HIV with undetectable viral load that are able to give informed consent to participate in the trial, in total 49 patients will be recruited. The investigational medical compounds in this trial are panobinostat, lenalidomide and pyrimethamine. These are all licensed drugs for other conditions. Participants of this trial will receive a single dose of the IMPs, either as monotherapy or as combination therapy. Sampling will be performed before, during and after medical treatment to evaluate latency reversal, reservoir reduction and safety endpoints. Patients will be recruited from the Erasmus MC, Amsterdam university Medical Center and the University Medical Center Utrecht.

2024-04-01

2025-05-01

2025-10-01

Not yet recruiting

Early phase I

49

Inclusion Criteria: * Documented HIV-1 infection by 4th generation ELISA, Western Blot or PCR. * ≥ 18 years old. * World Health Organization (WHO) performance status 0 or 1. * Current plasma HIV RNA \<50 copies/ml measured on the last 2 occasions, with measurements being at least 3 months apart. * Uninterrupted prescribed ART for a minimum of two consecutive years. * Considered \>95% adherent to ART by treating physician. * Current blood CD4+T-cell count of ≥200 cells/mm3 * No clinical signs of cellular immunodeficiency or AIDS. * Pre-ART plasma HIV RNA ≥1000 copies/mL. * Confirmed HIV subtype B. People with a high likelihood of subtype B can participate if they live in a HIV subtype B endemic region with HIV acquired there and in whom no HIV sequencing is available or can be done on stored samples. * People should be considered capable mentally and somatically by their treating physician to understand the informed consent procedure and undergo the study treatment. Exclusion Criteria: * A potential subject who meets any of the following criteria will be excluded from participation in this study: * Previous exposure to any of the studied LRAs in the last year * Acute or chronic co-infection with hepatitis B and/or C by the presence of hepatitis B surface antigen (HBsAg) or hepatitis C virus RNA in blood. * Co-medication with clinically significant interactions with LRA (see chapter 15.h for list) * Comorbidities affected by LRA compounds, such as but not limited to: known Glucose-6-phospate-dehydrogenase (G6PD) deficiency with anaemia, untreated haemolysis of any cause or hereditary thrombophilia not currently treated by anticoagulation. * Prolonged Qtc time \>480ms at screening, as measured by electrocardiogram (ECG). * Patients of childbearing potential unless double contraceptive measures are taken. Non-childbearing is defined by one of the following criteria: amenorrhoea for ≥ 1 year, premature ovarian failure, assigned male at birth, or having undergone previous bilateral salpingo-oophorectomy, or hysterectomy * Sexual active patients unwilling to abstain from sex unless willing to use condom protection during and until 1 week after administration of study medication. * Active malignancy during the past year with the exception of basal carcinoma of the skin, stage 0 cervical carcinoma, Kaposi's sarcoma treated with ARTalone or other indolent malignancies. * Registered allergies for any of the investigational medical products * Any lab abnormalities at screening as listed below: * Moderate kidney impairment, defined as eGFR \<50 mL/min * Moderate hepatic impairment, defined as bilirubin \> 3 x upper limit of normal (ULN) or ALT \> 3x ULN * Inadequate blood counts, defined as: Haemoglobin \<6.5 mmol/L (males) or \<6.0 mmol/L (females), absolute neutrophil count \<1000 cells/mm3, thrombocytes \<100 x109/L, international standardized ratio \>1.6, activated partial thromboplastin time \>40 seconds, serum sodium \<130 mmol/L, serum potassium \<3.0 mmol/L, serum phosphate \<0.5 mmol/L, serum calcium \<1.9 mmol/L, serum magnesium \<0.5 mmol/L.

{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1', 'PHASE2'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Open label randomized controlled trial.', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 49, 'type': 'ESTIMATED'}}

2024-02-05