Clinical trial
Vasopressin Modulates Neural Responses to Looming Visual Stimuli: An Eye-tracking Study
Name
BAM_lab_eyetracking_03
Description
The main aim of the present study is to investigate the effects of orally administered vasopressin (AVP) on the perception of time-to-collision of threatening and non-threatening stimuli by combining a validated looming fear eye-tracking paradigm with a randomized between-subject placebo-controlled pharmacological trial design.
Trial arms
Trial start
2024-03-05
Estimated PCD
2025-06-01
Trial end
2025-07-30
Status
Recruiting
Treatment
Vasopressin
Administration of vasopressin (20 IU) (oral spray)
Arms:
Vasopressin group
Other names:
Antidiuretic Hormone
Placebo
Administration of placebo (oral spray)
Arms:
Placebo group
Other names:
Placebo treatment
Size
80
Primary endpoint
Ratio of judged-time-to-collision to actual-time-to-collision for threatening versus non-threatening stimuli after oral vasopressin administration
75 minutes - 105 minutes after treatment
Eligibility criteria
Inclusion Criteria:
* Healthy subjects who volunteer to participate and are able to fully understand and agree with this study by written informed consent.
* Normal or corrected-normal version
Exclusion Criteria:
* History of neuropsychiatric diseases.
* History of cardiac disease, including arrhythmias, aortic stenosis, or congestive heart failure; history of syncope or unexplained loss of consciousness.
* History of hepatic diseases, including cholestasis, biliary obstructive disease, or severe liver dysfunction.
* History of renal diseases, including renal stones or renal failure.
* History of hyponatremia(Serum sodium \<135mmol/L) or hyperkalemia (Serum potassium\>5.5mmol/L); history of diabetes mellitus or diabetes insipidus
* Known hypersensitivity or allergic reaction to any medication or hormone; strong allergic reaction to food.
* Infections such as COVID-19 or influenza, or unexplained fever.
* Subjects with hypertension (BP ≥130/80mmHg) or hypotension (BP ≤ 90/60mmHg).
* History of alcohol or drug abuse; smoker (≥ 10 cigarettes or ≥ 3 cigars or ≥ 3 pipes/day); smoker using e-cigarettes.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['NA'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'BASIC_SCIENCE', 'maskingInfo': {'masking': 'DOUBLE', 'maskingDescription': 'Randomized placebo-controlled double-blind between-subject design', 'whoMasked': ['PARTICIPANT', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 80, 'type': 'ESTIMATED'}}
Updated at
2024-04-11
1 organization
1 product
1 drug
1 indication
Product
VasopressinIndication
HealthyDrug
Varlilumab