Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department: a Multicenter Randomized Controlled Double-blind Non-inferiority Trial

RC19_0116

In emergency medicine, acute pain is a common reason for consultation. It is recommended that patients in moderate to severe pain should receive a combination of intravenous acetaminophen and morphine. However, the data are sparse to support this strategy. Thus, the purpose of our research is to test non-inferiority of IV morphine alone versus IV acetaminophen and morphine in a multicenter, randomized, controlled double blind trial in ED patients with moderate to severe acute pain.

2019-12-03

2024-06-03

2024-06-03

Early phase I

572

Inclusion Criteria: * 18 Years and older * Moderate to severe acute pain, defined as a numeric rating scale score greater than or equal to 5. * Conscious patient * Clinical stability at the physician's discretion * Patient able to talk and give a verbal assessment of his/her pain with the numerical verbal scale * Out of guardianship and/or tutorship * Affiliated to the social security plan. Exclusion Criteria: * Pregnancy and Breast-feeding * Patient Unable to give numeric rating scale scores * Patient with a weight strictly less than 50kg. * acute pulmonary edema, acute respiratory failure * Acute coronary syndrome or unbalanced ischemic heart disease in progress. * Acute alcoholic intoxication. * Patient who received morphine, or acetaminophen, or analgesic, or anti-inflammatory, for the current acute pain episode, within 8 hours prior to arrival at the emergencies * No possibility of having venous access * History of chronic pain during treatment. * Allergy, intolerance or know contraindication to paracetamol or morphine or to an excipient. * Renal or hepatic insufficiency. * Association with buprenorphine, nalbuphine and pentazocine. * Patient unable or unable to give written consent.

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2023-03-08