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Nantes University Hospital

53 clinical trials

3 abstracts

Clinical trial
Optimization of Skin Preparation to Reduce Cutibacterium Acnes Colonization in Superficial and Deep Samples During Prosthetic Shoulder Surgery in Male Patients
Status: Recruiting, Estimated PCD: 2027-06-01
Clinical trial
A Multicenter Real-life Observational Retrospective Study Switched Aflibercept or Ranibizumab to Faricimab in Patients With Refractory or Dependent Exudative AMD
Status: Not yet recruiting, Estimated PCD: 2025-04-01
Clinical trial
A Phase III Randomized, Blind, Double Dummy, Multicenter Study Assessing the Efficacy and Safety of IV THrombolysis (Alteplase) in Patients With acutE Central retInal Artery Occlusion
Status: Completed, Estimated PCD: 2024-01-16
Clinical trial
Minimal Residual Disease-based Strategy With T-Cell Redirector After Treatment With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone (D-VRd) in Newly Diagnosed Multiple Myeloma: A Phase 2 (IFM 2022-01)
Status: Not yet recruiting, Estimated PCD: 2026-04-20
Clinical trial
Biocollection on Peripheral Inflammation in Psychiatric Pathologies
Status: Recruiting, Estimated PCD: 2026-08-02
Clinical trial
Efficacy of Soluble Dexamethasone by Echo-guided Infiltration Through the Sacrococcygeal Hiatus in Refractory Sciatica: a Prospective Randomised Double-blind Study Versus Placebo
Status: Completed, Estimated PCD: 2023-03-15
Clinical trial
Amoxicillin Alone Versus Amoxicillin/Clavulanate for Community-acquired Pneumonia in Patients Aged 65 Years or Older, and Hospitalized in a Non-intensive Care Unit Ward: a Non-inferiority Randomized Controlled Trial
Status: Not yet recruiting, Estimated PCD: 2027-04-15
Clinical trial
Prospective, Multicenter, Randomized, Open-label, Parallel-group Controlled Phase 3 Study of Tacrolimus Minimization in Kidney Transplant Recipients Selected According to the AGORA Algorithm for Their Low Immunological Risk and Medium-term Graft Failure
Status: Not yet recruiting, Estimated PCD: 2026-08-10
Clinical trial
Phase 1 Dose Escalation of Early Infusion of Zoledronic Acid in Combination With Increasing Low-dose of Interleukin-2 in Order to Expand Vγ9Vδ2 T Cells After T-replete Haplo-identical Allogeneic Stem Cell Transplantation (SCT)
Status: Completed, Estimated PCD: 2023-08-29
Clinical trial
Predictive Signature of Benralizumab Response
Status: Recruiting, Estimated PCD: 2026-10-01
Clinical trial
Evaluation of Diabetic or Uveitic Macular Edema After Injection of a Fluocinolone Acetonide (AcF) Implant 1 Month After the Last Dexamethasone (DXM) Implant: Evaluation at 3 Years
Status: Recruiting, Estimated PCD: 2024-06-01
Abstract
Phase 3 trial evaluating efficacy and safety of odronextamab plus CHOP vs rituximab plus CHOP in previously untreated diffuse large B-cell lymphoma (DLBCL; OLYMPIA-3).
Org: Division of Blood Disorders, Rutgers Cancer Institute of New Jersey and RWJBarnabas Health, Namık Kemal Üniversitesi, Nantes University Hospital, Centre Hospitalier Universitaire (CHU) de Poitiers,
Clinical trial
Multicentric Phase 1 Study With Escalation of Doses of Daratumumab in Combination With Chemotherapy (Idarubicin and Cytarabine) in Patients of 60 Years Old or More With Adverse Risk Acute Myeloblastic Leukemia (AML) (DARALAM)
Status: Not yet recruiting, Estimated PCD: 2028-01-01
Clinical trial
Dexamethasone for Treating Severe Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype, an International Phase III, Double-blind, Placebo-controlled, Randomized Trial
Status: Not yet recruiting, Estimated PCD: 2026-03-14
Clinical trial
NAlmefene Versus Placebo in Addition to Treatment as Usual on Craving in Behavioural Addictions
Status: Recruiting, Estimated PCD: 2025-07-01
Clinical trial
A Phase I/II Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Efficacy of FR104, a Novel Antagonist Pegylated Anti-CD28 Fab' Antibody Fragment in de Novo Renal Transplant Patients
Status: Active (not recruiting), Estimated PCD: 2024-03-01
Clinical trial
Comparison of Pharmacokinetic (PK) Levels Before and After Conversion From Twice-daily Tacrolimus to Once-daily Extended-release Tacrolimus (LCPT) in Diabetic Transplant récipients
Status: Completed, Estimated PCD: 2023-11-07
Clinical trial
Exploratory Study Evaluating the Relevance of [68Ga]Ga-PentixaFor for Initial Staging and Detection of Minimal Residual Disease in Multiple Myeloma Patients Eligible for Autologous Stem Cell Transplantation Less Than 66 Years Included in the Prospective IFM 2020-02.
Status: Withdrawn, Estimated PCD: 2023-05-04
Clinical trial
Exploratory Study Evaluating the Relevance of [68Ga]Ga -PentixaFor for Initial Staging and Therapeutic Evaluation of Symptomatic Multiple Myeloma Patients in First Line Treatment
Status: Recruiting, Estimated PCD: 2029-12-21
Clinical trial
Pilot Study on the Treatment of Anal Fistulas in Crohn's Disease Patients Using Alofisel Versus Fat Autologous Stem Cells
Status: Not yet recruiting, Estimated PCD: 2025-01-01
Clinical trial
Genetics of Ventriculo-arterial Discordance: Towards a PRECIsion Medicine in PEDiatric Cardiology
Status: Recruiting, Estimated PCD: 2025-08-01
Clinical trial
Dupilumab Step-down Strategy to Maintain Remission in Adult and Adolescents Patients With Atopic Dermatitis: a Non-inferiority Randomized Trial
Status: Recruiting, Estimated PCD: 2026-03-08
Clinical trial
InSaKa Trial: Insulin Dextrose Infusion Versus Nebulized Salbutamol Versus Combination of Salbutamol and Insulin Dextrose in Acute Hyperkalemia: a Randomized Clinical Trial
Status: Recruiting, Estimated PCD: 2025-12-20
Clinical trial
Pilot Study: Interest of Belatacept as a Non-nephrotoxic Immunosuppressive Treatment in Cardiac Transplant Patients at Risk of Chronic Renal Failure
Status: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
FLUCLORIC: Randomized Multicentric Phase III Study Comparing the Efficacy of 2 Reduced Intensity Conditioning Regimens (Clofarabine/Busulfan vs Fludarabine/Busulfan) in Adults With AML and Eligible to Allogeneic Stem Cell Transplantation
Status: Recruiting, Estimated PCD: 2028-09-14
Clinical trial
Phase I/II Study Assessing Radioligand Therapy (RLT) Using [177Lu]Lu-PentixaTher for Relapsed/Refractory CXCR4+ Acute Leukemia.
Status: Not yet recruiting, Estimated PCD: 2027-05-15
Clinical trial
Effect of Baclofen to Prevent Post-Traumatic Stress Disorder: 5 Years Follow-up of the BACLOREA Randomized Trial
Status: Recruiting, Estimated PCD: 2025-09-03
Clinical trial
Belatacept as a Replacement for CNIs 3 to 12 Months Post-transplantation in Patients With Early Graft Dysfunction
Status: Recruiting, Estimated PCD: 2027-05-03
Clinical trial
Phase 3 Confirmatory, Randomised 1:1 Double-blind, Placebo-controlled Study Evaluating the Analgesic Efficacy of Capsaicin 8% Patches in Chronic Coccygodynia.
Status: Recruiting, Estimated PCD: 2027-01-08
Clinical trial
HYPOCHOL : A Genetically-based Strategy to Identify New Targets in Cholesterol Metabolism
Status: Active (not recruiting), Estimated PCD: 2022-01-07
Clinical trial
Clot Formation and Coagulation Factors Consumption Over Time in the Clearing Fluid After Arterial Catheter Blood Sampling in Critically Ill Adult Patients. Prospective Observational Study.
Status: Recruiting, Estimated PCD: 2025-03-20
Clinical trial
Comparison of Respiratory Tolerance to I.V. Versus Sublingual Sedation During Bronchoscopy.
Status: Terminated, Estimated PCD: 2014-12-01
Clinical trial
Phase II Trial Studying the Efficacy of a Triplet Combination of MLN9708, Lenalidomide and Dexamethasone as Induction Prior to, and as Consolidation After High-dose Therapy With Peripheral Stem Cell Transplantation Followed by MLN9708 Maintenance in the Initial Management of Multiple Myeloma in Patients Younger Than 66 Years
Status: Completed, Estimated PCD: 2019-03-01
Clinical trial
Efficacy of Nasal Oxygen Therapy to Reduce Postoperative Complications in Ankle Trauma Surgery in At-risk Patients: a Randomized Pilot Study
Status: Recruiting, Estimated PCD: 2024-07-01
Clinical trial
Controlled Comparison of a Traditional Dressing Versus a Biologic Dressing Composed of Fetal Fibroblasts and Keratinocytes in Association With a Collagen Matrix on Skin Donor Sites
Status: Recruiting, Estimated PCD: 2024-11-16
Clinical trial
Neuropathic Determining Factors and Analgesic Efficacy of Capsaicin 8% (QUTENZA®) Patches in Refractory Coccygodygnia
Status: Not yet recruiting, Estimated PCD: 2023-12-17
Clinical trial
Impact Evaluation of Perioperative Locoregional Analgesia on Persistent Postoperative Pain in Children After Orthopedic Surgery for Traumatology : a Prospective, Single Center, Randomised Controlled Study.
Status: Not yet recruiting, Estimated PCD: 2026-05-01
Clinical trial
"Baricitinib for Treating Hospital-acquired Pneumonia in Critically Ill Patients With a Proinflammatory Phenotype, an International Phase II/Phase III, Randomized, Controlled Trial - TREAT-HAP Study.
Status: Not yet recruiting, Estimated PCD: 2025-08-31
Clinical trial
IDEntification of New Predisposition Genes in Differentiated THYroid Cancer
Status: Active (not recruiting), Estimated PCD: 2026-02-01
Clinical trial
Randomized Double-blind Study on the Benefit of Spironolactone for Treating Acne of Adult Woman.
Status: Completed, Estimated PCD: 2023-02-03
Clinical trial
Risk Stratification of Sudden Unexpected Death in Infant Based on Biomarkers - Identification of Genetic Variants Associated With Unexpected Infant Death Syndrome
Status: Not yet recruiting, Estimated PCD: 2026-02-01
Clinical trial
A Multi-center Open-label Phase 2 Study of Ixazomib, Iberdomide and Dexamethasone in Elderly Patients With Multiple Myeloma at First Relapse."
Status: Active (not recruiting), Estimated PCD: 2025-01-01
Clinical trial
A Phase 1 Dose-escalation Study Testing the Feasibility and the Tolerance of Infusion of a Specific Third Party Suicide Gene-transduced Anti-HLA-DPB1*0401 CD4+ T Cell Clone in HLA-DPB1*04:01 Positive Tumor Recipients Receiving an Allotransplant From a HLA-DPB1*04:01 Negative Donor.
Status: Recruiting, Estimated PCD: 2025-02-01
Clinical trial
Monocentric Phase 1 Study With Escalation of Doses of Tocilizumab in Combination With Chemotherapy (Idarubicin and Cytarabine) in Patients With Acute Myeloblastic Leukemia (AML) With Poor Prognosis: TOCILAM"
Status: Completed, Estimated PCD: 2023-04-04
Clinical trial
Monocentric Phase 1 Study With Dose-escalation of Siltuximab in Combination With Idarubicin and Cytarabine Chemotherapy in Patients With Acute Myeloblastic Leukaemia (AML) With Poor Prognosis: SILTUXILAM
Status: Recruiting, Estimated PCD: 2025-06-30
Clinical trial
Intravenous Acetaminophen and Morphine Versus Intravenous Morphine Alone for Acute Pain in the Emergency Department: a Multicenter Randomized Controlled Double-blind Non-inferiority Trial
Status: , Estimated PCD: 2024-06-03
Clinical trial
Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation
Status: Recruiting, Estimated PCD: 2028-04-09
Clinical trial
Randomized Phase 2 Study Testing Two Conditioning Regimen With a Single Prophylaxis of Graft-versus-host Disease by Cyclophosphamide and Methotrexate Post-transplant in Patients Eligible for Matched-donor Allograft Transplantation
Status: Not yet recruiting, Estimated PCD: 2027-09-15
Clinical trial
Phase 3 Therapeutic Interventional Study Evaluating the Efficacy of Noradrenaline in the Prevention of Hypotension Related to Intubation for Cardiac or Thoracic Surgery - Single-centre Prospective Randomised Controlled Study With Blinded Assessment of the Primary Endpoint
Status: Completed, Estimated PCD: 2023-12-12
Clinical trial
Development of a Biomarker of Efficacy of Vedolizumab (EnTyvio®) in Patients With ulcErative ColiTis (DETECT)
Status: Terminated, Estimated PCD: 2020-01-01
Clinical trial
An Open Single-center, Phase I Proof of Concept Trial to Assess the Safety and Feasibility of Adoptive Cell Therapy With Autologous EBV-specific Cytotoxic T Lymphocytes (CTL) in Patients With a First Clinical Episode Highly Suggestive of Multiple Sclerosis
Status: Recruiting, Estimated PCD: 2026-11-01
Clinical trial
Brain Microglial Activation in the Early Stage of the Parkinson's Disease: a Predictive Biomarker of the Evolution?
Status: Active (not recruiting), Estimated PCD: 2024-05-06
Clinical trial
MELROSE: Phase 2 Study Evaluating MEchanisms of Resistance on Tumor Tissue and Liquid Biopsy in Patients With EGFR Mutated Nonpretreated Advanced Lung Cancer Receiving OSimErtinib Until and Beyond Radiological Progression : the MELROSE Trial
Status: Active (not recruiting), Estimated PCD: 2025-01-01
Abstract
Impact of first-line immunotherapy on survival and intracranial outcomes from a real-world cohort of non-small cell lung cancer patients with brain metastases at diagnosis.
Org: Nantes University Hospital, Institut de Cancérologie de l'Ouest, Angers, France, Nantes Université, CHU Nantes-Department of Hepato-Gastroenterology, Inserm U1308- CAPTuR- Control of cell Activation in Tumor Progression and Therapeutic Resistance,
Abstract
Prognostic impact of TP53 mutations in metastatic non-squamous non-small-cell lung cancer.
Org: Institut de Cancérologie de l'Ouest, Angers, France, Nantes University Hospital, Nantes Université, CHU Nantes-Department of Hepato-Gastroenterology, Inserm U1308- CAPTuR- Control of cell Activation in Tumor Progression and Therapeutic Resistance,
Clinical trial
Exploratory Study Evaluating the Interest of PET to 18F-Fludarabine for the Initial Assessment and End-treatment Evaluation of Patients With Symptomatic Multiple Myeloma in the First Line of Treatment, Not Candidates for Marrow Autograft
Status: Recruiting, Estimated PCD: 2024-09-09