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Clinical trial

Determine the Effects of Prone Positioning and Nitric Oxide in Adult COVID-19 Patients With ARDS by Electrical Impedance Tomography

ID
Name
eit20221221
Description
We aims to investigate the effects of prone positioning and nitric oxide inhalation in adult patients who is diagnosed with COVID-19 associated acute respiratory distress syndrome by electrical impedance tomography.
Trial arms
Trial start
2022-12-21
Estimated PCD
2023-06-30
Trial end
2023-12-31
Status
Recruiting
Treatment
prone postion
ventilation at prone positioning
Arms:
Ventilation in prone position for 1 hour, Ventilation in prone position for 16 hours, Ventilation in prone position for 2 hours plus NO inhalation for 1 hour, Ventilation in prone position for 3 hours
Other names:
PPV
NO inhalation
NO inhalation at 20 ppm
Arms:
Ventilation in prone position for 2 hours plus NO inhalation for 1 hour, Ventilation in supine position and NO inhalation
Size
20
Primary endpoint
oxygenation status
1 day
regional distribution of pulmonary perfusion
1 day
regional distribution of pulmonary ventilation
1 day
Eligibility criteria
Inclusion Criteria: * adult patients who have COVID-19-associated acute respiratory distress syndrome Exclusion Criteria: * patients who refuse to participate in the study; unable to use EIT, such as open-chest surgery with chest tube placement; have contraindication for prone positioning, including pregnant, post-abdomen surgery within a week; hypercapnic respiratory failure.
Protocol
{'studyType': 'OBSERVATIONAL', 'patientRegistry': True, 'targetDuration': '1 Day', 'designInfo': {'observationalModel': 'COHORT', 'timePerspective': 'PROSPECTIVE'}, 'enrollmentInfo': {'count': 20, 'type': 'ESTIMATED'}}
Updated at
2023-02-08

1 organization

1 product

3 indications

Organization
Shanghai Zhongshan Hospital
Product
NO inhalation
Indication
Respiratory Distress Syndrome
Indication
Adult
Indication
COVID-19