Clinical trial
Single-center, Double-blind (ACT-246475), Open-label (Clopidogrel, Prasugrel, and Ticagrelor), Placebo-controlled, Randomized, Two-way Crossover Study to Investigate the Pharmacodynamics, Safety, and Tolerability of a Single Oral Dose of Clopidogrel or, Prasugrel, or Ticagrelor When Administered After a Single Subcutaneous Dose of the P2Y12 Antagonist ACT-246475 in Healthy Male and Female Subjects
Name
ID-076-103
Description
The primary objective of this study is to assess the pharmacodynamic (PD) effects of clopidogrel, prasugrel, and ticagrelor when administered after a single subcutaneous (s.c.) dose of ACT-246475 in healthy male and female subjects
Trial arms
Trial start
2018-01-24
Estimated PCD
2019-05-20
Trial end
2019-05-29
Status
Completed
Phase
Early phase I
Treatment
ACT-246475
Lyophilized ACT-246475A to be reconstituted with 1 mL of water for injection
Arms:
Part A: Group 1, Part A: Group 2, Part A: Group 3, Part B: Group 1, Part B: Group 2, Part B: Group 3, Part C: Group 1, Part C: Group 2, Part C: Group 3
Clopidogrel
Tablet for oral administration (300 or 600 mg)
Arms:
Part A: Group 1, Part A: Group 2, Part A: Group 3
Prasugrel
Tablet for oral administration (60 mg)
Arms:
Part B: Group 1, Part B: Group 2, Part B: Group 3
Placebo
Matching ACT-246475 placebo will consist of sterile 0.9% w/v sodium chloride solution
Arms:
Part A: Group 1, Part A: Group 2, Part A: Group 3, Part B: Group 1, Part B: Group 2, Part B: Group 3, Part C: Group 1, Part C: Group 2, Part C: Group 3
Ticagrelor
Tablet for oral administration (180 mg)
Arms:
Part C: Group 1, Part C: Group 2, Part C: Group 3
Size
77
Primary endpoint
Time-matched comparisons of IPA% (MPA) between treatments (i.e., Treatment A1 vs A2, Treatment B1 vs B2, and treatment C1 vs C2, treatments are defined below) following administration of ACT-246475 and its matching placebo.
From baseline up to 48 hours
Time-matched comparisons of IPA %(PRU) between treatments (i.e., Treatment A1 vs A2, Treatment B1 vs B2, and treatment C1 vs C2) following administration of ACT-246475 and its matching placebo.
From baseline up to 48 hours
Eligibility criteria
Main Inclusion Criteria:
* Signed informed consent
* Healthy male and female subjects aged between 18 and 65 years (inclusive) at screening
* Body mass index of 18.0 to 31.0 kg/m2 (inclusive) at Screening
* Women of childbearing potential must have a negative serum pregnancy test and use reliable birth controls from screening up to at least 30 days after last study treatment administration
* Systolic blood pressure (SBP) 100-140 mmHg, diastolic blood pressure (DBP) 50-90 mmHg, and pulse rate 50-90 beats per minute (bpm) (inclusive) at screening
* Healthy on the basis of physical examination, cardiovascular assessments, and laboratory tests
* Maximum (at peak) platelet aggregation ≥ 40% (light transmission aggregometry \[LTA\]) upon 20 μM adenosine diphosphate (ADP) activation at screening
* Values of closure time tested with the Platelet Function Analyzer (PFA) equipment, for both cartridges of collagen/adrenaline and collagen/ADP below the upper limit of normal range at screening
Main Exclusion Criteria:
* Pregnant or lactating women
* Known hypersensitivity to ACT-246475, clopidogrel, prasugrel, ticagrelor, any of their excipients, or drugs of the same class
* Any contraindication to clopidogrel, prasugrel, or ticagrelor treatment
* Known hypersensitivity or allergy to natural rubber latex
* Platelet count \< 120 × 109 L-1 at Screening and Day -1
* Known platelet disorders (e.g., Glanzmann thromboasthenia, von Willebrand disease, platelet release defect)
* Previous treatment with acetylsalicylate, non-steroidal anti-inflammatory drugs, P2Y12 receptor antagonists, or any medication with blood-thinning activity (i.e., injectable or oral anticoagulants) within 3 weeks prior to study treatment administration
* Any circumstances or conditions, which, in the opinion of the investigator, may affect full participation in the study or compliance with the protocol
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'primaryPurpose': 'OTHER', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'INVESTIGATOR']}}, 'enrollmentInfo': {'count': 77, 'type': 'ACTUAL'}}
Updated at
2022-11-16
1 organization
5 products
1 indication
Organization
Idorsia PharmaceuticalsProduct
ClopidogrelIndication
HealthyProduct
PlaceboProduct
ACT-246475Product
PrasugrelProduct
Ticagrelor