A Randomized Sham and Placebo-controlled Trial of Adjunctive D-cycloserine in Repetitive Transcranial Magnetic Stimulation for Obsessive Compulsive Disorder

REB21-0265

Obsessive Compulsive Disorder (OCD)is a common and debilitating illness. For an unacceptable proportion of patients, depressive symptoms remain impairing despite multiple treatments. In August 2018, the FDA approved transcranial magnetic stimulation (TMS) for the treatment of OCD based on a large study demonstrating efficacy. Our neurophysiological data and clinical data in depression suggests that we can enhance the effects of TMS by using an adjunctive medication called D-Cyloserine (DCS, 100mg) in conjunction with stimulation. The mechanism by which this is achieved is called synaptic plasticity, or the activity dependent changes that occur with brain stimulation. Research Question and Objectives: To conduct a randomized sham- and placebo-controlled trial of DCS in adjunct with rTMS in OCD. Participants will be randomized to receive 100mg of DCS or placebo together with TMS.

2021-11-26

2024-10-01

2025-10-01

Active (not recruiting)

Early phase I

81

Inclusion Criteria: 1. Males and females aged 18 to 65 years 2. are competent to consent to treatment 3. have a Mini-International Neuropsychiatric Interview (MINI) confirmed diagnosis of DSM-5 criteria Obsessive Compulsive Disorder. 4. have failed to achieve a clinical response to one adequate trial of serotonin reuptake inhibitor or cognitive behavioral therapy with an adequate trial of 2 months medication within the current episode, or been unable to tolerate antidepressant medications. 5. have a score ≥ 20 on the YBOCS. 6. have had no change in dose, or initiation of any psychotropic medication in the 8 weeks prior to randomization 7. are able to adhere to the treatment schedule 8. pass the TMS adult safety screening (TASS) questionnaire Exclusion Criteria: 1. Allergy to cycloserine. 2. have an alcohol or substance use disorder within the last 3 months 3. have suicidal ideation (score of 4 ≥ on item 10 of MADRS) 4. are at a significant risk of harm to themselves or others 5. Current symptoms of psychosis 6. History of psychosis 7. are currently pregnant , breast feeding or plan to become pregnant 8. have a lifetime Mini-International Neuropsychiatric Interview (MINI) diagnosis of other primary psychiatric diagnoses as assessed by a study investigator to be primary and causing greater impairment than Major Depressive Disorder. 9. have failed a course of ECT in the current episode. Previous ECT treatment outside of the current episode does not influence inclusion. 10. history of non-response to rTMS treatment. 11. have any significant neurological disorder or insult including, but not limited to: any condition likely to be associated with increased intracranial pressure, space occupying brain lesion, any history of epilepsy, cerebral aneurysm, Parkinson's disease, Huntington's chorea, multiple sclerosis, significant head trauma with loss of consciousness for greater than or equal to 5 minutes 12. have concomitant major unstable medical illness, cardiac pacemaker or implanted medication pump 13. have an intracranial implant (e.g., aneurysm clips, shunts, stimulators, cochlear implants, or electrodes) or any other metal object within or near the head, excluding the mouth, that cannot be safely removed 14. If participating in psychotherapy, must have been in stable treatment for at least 3 months prior to entry into the study, with no anticipation of change in the frequency of therapeutic sessions, or the therapeutic focus over the duration of the study 15. are currently (or in the last 4 weeks) taking lorazepam or any other benzodiazepine due to the potential to limit rTMS efficacy

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2023-09-13