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Clinical trial

Mood Effects of Serotonin Agonists Extended

ID
Name
IRB18-1183
Description
In this study we are examining the effects of repeated very low doses of serotonin agonists on mood individuals with negative mood.
Trial arms
Trial start
2019-04-20
Estimated PCD
2021-06-07
Trial end
2021-06-07
Status
Completed
Phase
Early phase I
Treatment
Placebo
Drug will be administered in solution form
Arms:
Placebo
Serotonin agonist - 13ug
13ug lysergic acid diethylamide
Arms:
Serotonin agonist 13ug
Other names:
LSD
Serotonin agonist - 26ug
26ug lysergic acid diethylamide
Arms:
Serotonin agonist 26ug
Other names:
LSD
Size
56
Primary endpoint
DASS-21
End of session 5, approximately 2 weeks from baseline
Eligibility criteria
Inclusion Criteria: * English fluency * High school level education * BMI between 19 and 30 Exclusion Criteria: * Diagnosed medical condition * women who are nursing, pregnant, or plan to become pregnant within 3 months * History of psychotic disorder or family history of psychotic disorder
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE1'], 'designInfo': {'allocation': 'RANDOMIZED', 'interventionModel': 'PARALLEL', 'interventionModelDescription': 'Randomized', 'primaryPurpose': 'BASIC_SCIENCE', 'maskingInfo': {'masking': 'TRIPLE', 'whoMasked': ['PARTICIPANT', 'CARE_PROVIDER', 'OUTCOMES_ASSESSOR']}}, 'enrollmentInfo': {'count': 56, 'type': 'ACTUAL'}}
Updated at
2023-11-29

1 organization

2 products

1 indication

Organization
University of Chicago
Product
Placebo
Indication
Healthy
Product
Serotonin agonist