Clinical trial
Docetaxel With Rapid Hormonal Cycling as a Treatment for Patients With Prostate Cancer
Name
03-076
Description
We postulate that multiple apoptototic events are indusce through testosterone depletion and repletion with taxotere given in conjunction with androgen withdrawal.
Trial arms
Trial start
2003-07-01
Estimated PCD
2008-02-01
Trial end
2008-02-01
Status
Completed
Phase
Early phase I
Treatment
GnRh (Leuprolide)
Leuprolide LUPRON
Arms:
1, 2
Other names:
22.5 mg intramuscular injection
Testosterone Gel
Starting during week 3 (day 19) of cycle 1, 7.5G applied topically daily for 3 days (applied at approximately 9p)
Arms:
1, 2
Other names:
AndroGel
Docetaxel
70 mg/m2 given on day o1 of each 3 week cycle
Arms:
1
Other names:
Taxotere
Size
102
Primary endpoint
PSA of <_ 0.05 ng/ml After Radical Prostatectomy or Radiation Therapy and PSA <_ 2.0 ng/ml for Patients With Clinical Metastases Without Prior Definitive Therapy
Conclusion of the study (at 6 months then at 18 months post-treatment)
Eligibility criteria
Inclusion Criteria:
* Diagnosis of prostate adenocarcinoma histologically confirmed at MSKCC or SKCCC.
* Patient must have a serum testosterone \> 180 ng/dl.
* Karnofsky performance status (KPS)\>_70%.
* Patients must have adequate organ function as defined by the following
* laboratory criteria:
* WBC \>_ 3500/mm3
* ANC \>_1500/mm3
* Platelet count \>100,000/mm3
* Hemoglobin \>8.0g/dL
* Creatinine \<1.6mg/dl
* Total Bilirubin WNL (unless due to Gilbert's disease and other LFTs are WNL)
* SGOT and SGPT If alkaline phosphatase is _\< 2.5 x ULN, any elevations in
* AST/ALT; OR if AST/ALT is _\<1.5 x ULN, any elevation in alkaline phos
* Prior hormonal therapy is allowed as:
1. Neoadjuvant treatment prior to radiation therapy or radical pmstatectomy, provided that the total duration of therapy does not exceed 6 months (Proscar is not considered a hormone therapy).
2. One cycle of intermittent therapy up to a maximum exposure of 6 months (Proscar is not considered a hormone therapy).
* Patients must be at least 18 years of age.
* Patients must have signed an informed consent document stating that they understand the investigational nature of the proposed treatment
Exclusion Criteria:
* Clinically significant cardiac disease (New York Heart Association Class III/IV), or severe debilitating pulmonary disease.
* Uncontrolled serious active infection.
* Anticipated survival of less than 3 months.
* Active CNS or epiduraltumor
* Inability or unwillingness to comply with the treatment protocol, follow-up, or research tests
* Peripheral neuropathy \>_ grade 3.
* Patients with a history of severe hypersensitivity reaction to drugs formulated with polysorbate 80.
* Men of childbearing potential must be willing to consent to using effective contraception while on treatment and for at least 6 months after completion of the treatment.
* Prior chemotherapy
* Concomitant use of phenytoin, carbamazepine, barbiturates, rifampicin, phenobarbital, St. Johns's Wort (hypericum perforatum) and ketoconazole is prohibited.
Protocol
{'studyType': 'INTERVENTIONAL', 'phases': ['PHASE2'], 'designInfo': {'allocation': 'NON_RANDOMIZED', 'interventionModel': 'SINGLE_GROUP', 'primaryPurpose': 'TREATMENT', 'maskingInfo': {'masking': 'NONE'}}, 'enrollmentInfo': {'count': 102, 'type': 'ACTUAL'}}
Updated at
2023-11-07
1 organization
2 products
1 drug
1 indication
Organization
Memorial Sloan Kettering Cancer CenterProduct
GnRh (Leuprolide)Indication
Prostate CancerProduct
TestosteroneDrug
Docetaxel