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Asthma

364 clinical trials

369 products

7 drugs

Clinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group, 12 Week Proof-of-Concept (PoC) Study to Assess the Efficacy, Safety, and Tolerability of Rilzabrutinib in Participants With Moderate-to-severe Asthma Who Are Not Well Controlled on Inhaled Corticosteroid (ICS) Plus Long-acting β2 Adrenergic Agonist (LABA) Therapy
Status: Completed, Estimated PCD: 2024-02-06
Product
Rilzabrutinib
Product
placebo
Product
Salbutamol
Clinical trial
A Randomized, Double-blind, Parallel Group, Multi-center Study to Evaluate the Long-term Safety of Salbutamol Rescue Medication When Administered Via Metered Dose Inhalers Containing the Propellant HFA-152a or Reference HFA-134a
Status: Not yet recruiting, Estimated PCD: 2025-04-25
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of IBI3002 in Healthy Participants and Participants With Mild to Moderate Asthma
Status: Recruiting, Estimated PCD: 2025-02-15
Product
IBI3002
Product
Placebo
Clinical trial
A Phase 3, 24-week, Randomized, Double-blind, Parallel-group Bayesian Dynamic Borrowing Study Comparing the Efficacy, Safety, Tolerability and Pharmacokinetics of FF/UMEC/VI With FF/VI in 12-17-year-old Participants With Inadequately Controlled Asthma on Stable Maintenance Therapy With ICS/LABA
Status: Recruiting, Estimated PCD: 2024-11-18
Product
FF/UMEC/VI
Product
FF/VI
Product
Mometasone Furoate/Formoterol MDI
Clinical trial
A 26-Week Randomized, Double-Blinded, Active Controlled Study Comparing the Safety of Mometasone Furoate/Formoterol Fumarate MDI Fixed Dose Combination Versus Mometasone Furoate MDI Monotherapy in Adolescents and Adults With Persistent Asthma (Protocol No. P06241 Also Known as P202)
Status: Completed, Estimated PCD: 2016-11-30
Product
Tezepelumab
Clinical trial
A Phase I, Open-label Study to Evaluate the Pharmacokinetics of Tezepelumab in Children ≥ 5 to 11 Years of Age With Mild, Moderate, or Severe Asthma (TRAILHEAD)
Status: Completed, Estimated PCD: 2022-09-27
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled Phase Ⅱ Clinical Study to Evaluate the Efficacy and Safety of CM326 in Subjects With Moderate to Severe Asthma
Status: Recruiting, Estimated PCD: 2025-01-01
Clinical trial
A Phase 4, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel-group Study of the Effect of Dupilumab on Sleep Disturbance in Patients With Uncontrolled Persistent Asthma
Status: Completed, Estimated PCD: 2023-10-03
Product
SAR231893
Clinical trial
Digital Adherence Monitoring of Inhalative Therapy in Real- Life Conditions
Status: Completed, Estimated PCD: 2023-01-20
Product
MF/IND/GLY
Product
FDC therapy
Product
CM326
Product
KN-002
Clinical trial
Phase 1 Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety, PK, and PD of Single Ascending Doses of KN-002 in Healthy Subjects and Multiple Ascending Doses of KN-002 in Subjects With Mild Asthma, Moderate-Severe Asthma and COPD
Status: Active (not recruiting), Estimated PCD: 2023-12-20
Clinical trial
A Multicenter, Randomized, Double-blind, Parallel-group, Event-driven, Decentralized, Phase IIIb Study Comparing PT027 With PT007 Administered as Needed in Participants 12 Years of Age and Older With Asthma (BATURA)
Status: Active (not recruiting), Estimated PCD: 2025-03-27
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled Phase Ⅱ/Ⅲ Clinical Study to Evaluate the Efficacy and Safety of CM310 Recombinant Humanized Monoclonal Antibody Injection in Subjects With Moderate to Severe Asthma
Status: Recruiting, Estimated PCD: 2032-05-01
Product
BDA MDI
Product
AS MDI
Clinical trial
A Phase II, Randomised, Double-blind, Placebo-controlled Study to Assess the Efficacy and Safety of MEDI3506 in Adult Participants With Uncontrolled Moderate-to-severe Asthma
Status: Completed, Estimated PCD: 2022-12-12
Product
tiotropium
Clinical trial
PRospEctiVe charactErization of Asthma Patients Treated With DupilumAb in reaL World Setting
Status: Recruiting, Estimated PCD: 2026-12-21
Product
MEDI3506
Product
ARO-RAGE
Clinical trial
A Phase 1 Study Evaluating the Effects of ARO-RAGE Injection for Subcutaneous Administration in Healthy Subjects
Status: Completed, Estimated PCD: 2024-02-08
Clinical trial
A Double-dummy, Double-blind, Randomized, Parallel-group, Active Controlled Study to Evaluate the Efficacy and Safety of QVM149 (Indacaterol Acetate / Glycopyrronium Bromide / Mometasone Furoate) Compared to Salmeterol Xinafoate/Fluticasone Propionate in Children From 12 Years to Less Than 18 Years of Age With Asthma.
Status: Not yet recruiting, Estimated PCD: 2026-03-18
Product
QVM149
Product
Salmeterol Xinafoate + Fluticasone Propionate
Product
Dupilumab
Clinical trial
A Long-term, Prospective, Open, Multi-centre, Non-interventional Study to Evaluate the Effectiveness After Treatment With TA Bäume Top (Trees) and TA Gräser Top (Grass) Following a Perennial Posology in Children and Adults, as Well as Proofing the Non-inferiority of Children Compared to Adults
Status: Active (not recruiting), Estimated PCD: 2026-06-01
Product
CM310
Product
Standardised allergen extract from house dust mites
Clinical trial
A Prospective Observational Study Evaluating Relevance of Measurement Instruments in Assessing Effectiveness of ACARIZAX® in the Treatment of Moderate to Severe House Dust Mite Allergic Rhinitis With/Without Allergic Asthma in Chinese
Status: , Estimated PCD: 2025-05-20
Product
MATA
Product
Run-In Medication
Product
Rescue Medication
Clinical trial
Exacerbation Risk in Asthma
Status: Completed, Estimated PCD: 2021-11-02
Product
Long-acting β2-agonists
Product
Albuterol Sulfate inhalation aerosol
Product
Proair HFA
Clinical trial
A Randomized, Single-dose, Double-blind, Double-dummy, Placebo and Active Controlled, Crossover Design Study Using Bronchoprovocation to Evaluate the Pharmacodynamic Equivalence of the Test and Reference Metered Dose Inhalers (MDIs) Containing Albuterol Sulfate in Adult Patients With Stable Mild Asthma
Status: Recruiting, Estimated PCD: 2024-03-01
Product
Inhaled Corticosteroids
Product
Albuterol Sulfate
Clinical trial
A Randomized, Placebo Controlled, Double Blind Phase IIa Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Clinical Activity of Multiple Intravenous Doses of FB704A in Adults With Severe Asthma
Status: Recruiting, Estimated PCD: 2025-09-30
Product
FB704A
Product
Dexpramipexole
Clinical trial
A Clinical Study to Test the Safety, Exposure, and Pharmacodynamic Markers of CSL311 in Subjects With Mild-to-moderate Asthma and in Healthy Volunteers
Status: Completed, Estimated PCD: 2023-11-14
Product
Human beta common receptor antagonist monoclonal antibody
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Efficacy, Safety, and Tolerability of Dexpramipexole Administered Orally for 52 Weeks in Participants With Severe Eosinophilic Asthma
Status: Recruiting, Estimated PCD: 2026-06-01
Product
AD17002
Clinical trial
A Single-blind (Patient-blind), Randomized, Placebo-controlled, Intranasal Administration Study on Mechanisms and Potential Efficacy of AD17002 in Subjects With Poorly Controlled, Moderate to Severe Eosinophilic Asthma
Status: Recruiting, Estimated PCD: 2024-06-28
Product
Salmeterol Xinafoate / Fluticasone Propionate
Product
RPT193
Clinical trial
A Phase 2 Study to Evaluate the Efficacy and Safety of RPT193 in Adults With Moderate-to-severe T2-high Asthma Who Are Partially Controlled on Inhaled Corticosteroid and Long-acting Beta 2 Agonist Therapy
Status: , Estimated PCD: 2025-06-01
Clinical trial
Study HZA114971, A Multicentre Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Effects of a One-Year Regimen of Orally Inhaled Fluticasone Furoate 50 mcg Once Daily on Growth Velocity in Prepubertal, Paediatric Subjects With Asthma
Status: Completed, Estimated PCD: 2021-04-09
Product
Fluticasone furoate
Product
Montelukast
Product
Short Acting Beta 2 Agonist
Clinical trial
A 12-Week, Randomized, Open-Label, Parallel-Group Study to Evaluate the Mastery of Inhaler Technique for Budesonide Formoterol (BF) SPIROMAX® (160/4.5 and 320/9 mcg) as Compared With SYMBICORT® TURBOHALER® (200/6 and 400/12 mcg) as Treatment for Adult Patients With Asthma (The Easy Low Instruction Over Time [ELIOT] Study)
Status: Completed, Estimated PCD: 2015-03-13
Product
SYMBICORT TURBOHALER
Product
Budesonide and Formoterol Fumarate Dehydrate (BF)
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled Phase II Clinical Study to Evaluate the Efficacy and Safety of CM310 Recombinant Humanized Monoclonal Antibody Injection in Subjects With Moderate to Severe Asthma
Status: Completed, Estimated PCD: 2023-09-13
Clinical trial
A 12-week Double-blind, Multicentre, Randomised, Active-controlled, 2-arm, Parallel-group Clinical Trial to Evaluate the Safety of CHF5993 pMDI 200/6/12.5 μg HFA-152a, Compared to CHF5993 pMDI 200/6/12.5 μg HFA-134a, in Subjects With Asthma.
Status: Recruiting, Estimated PCD: 2024-08-25
Product
CHF5993
Product
610
Clinical trial
A Phase 2, Single-Dose, Randomized, Active and Placebo Controlled, Four-Period, Cross-Over Study of the Safety and Efficacy of Intranasal Epinephrine After Administration of ARS -1 or Albuterol in Subjects With Persistent Asthma
Status: Active (not recruiting), Estimated PCD: 2024-01-01
Clinical trial
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase III Clinical Trial to Evaluate the Efficacy and Safety of 610 in Chinese Adult Subjects With Severe Eosinophilic Asthma
Status: Not yet recruiting, Estimated PCD: 2026-06-01
Product
ARS-1
Product
Albuterol
Product
MF/IND/GLY plus sensor system
Clinical trial
Two Doses of the Intravenous Magnesium Sulfate Versus the Standard Single Dose With/Without Nebulized Budesonide for the Emergency Management of the Severe Asthma. A Randomized Controlled Trial.
Status: Recruiting, Estimated PCD: 2024-12-01
Product
MgSO4
Product
Nebulized normal saline
Product
Nebulized budesonide
Clinical trial
A Randomized, Double-Blind, Placebo Controlled Study Assessing the Long-term Effect of Dupilumab on Prevention of Lung Function Decline in Patients With Uncontrolled Moderate to Severe Asthma
Status: Recruiting, Estimated PCD: 2029-10-31
Product
CBP-201
Clinical trial
A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled, Efficacy and Safety Study of CBP-201 in Patients With Moderate to Severe Persistent Asthma With Type 2 Inflammation
Status: Completed, Estimated PCD: 2023-08-05
Clinical trial
Double-blind, Randomized, Active-controlled, Two-way Cross-over Study, With 12-week Treatment Duration Per Period, to Evaluate the Efficacy and Safety of QMF149 (Indacaterol Acetate / Mometasone Furoate) Compared to Budesonide in Children From 6 to Less Than 12 Years of Age With Asthma
Status: Recruiting, Estimated PCD: 2026-05-14
Product
Budesonide
Clinical trial
A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter Variable Length Study to Assess the Efficacy and Safety of PT010 Relative to PT009 and Symbicort® in Adult and Adolescent Participants With Inadequately Controlled Asthma
Status: Recruiting, Estimated PCD: 2025-03-21
Product
BGF MDI 320
Product
BFF pMDI 320/9
Product
BGF MDI 320/28.8/9.6 μg
Product
BFF MDI
Product
QMF149
Clinical trial
An Open-Label Long-Term Phase III Extension Study to Assess the Long-Term Safety and Tolerability of Dexpramipexole in Participants With Severe Eosinophilic Asthma
Status: , Estimated PCD: 2027-06-01
Product
BFF MDI 320/9.6 μg
Clinical trial
A Randomized, Double-Blind, Parallel Group, Multicenter 24 Week Study to Assess the Efficacy and Safety of Budesonide and Formoterol Fumarate Metered Dose Inhaler Relative to Budesonide Metered Dose Inhaler and Open-Label Symbicort® Turbuhaler® in Participants With Inadequately Controlled Asthma (VATHOS).
Status: Recruiting, Estimated PCD: 2024-12-02
Product
BD MDI 320
Product
BFF MDI 160/9.6
Product
Symbicort
Clinical trial
A Randomized, Double-blind, Multicenter, Parallel Group, Phase IIIb 52 Week Study Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Participants 12 to < 18 Years of Age With Asthma (ACADIA)
Status: Not yet recruiting, Estimated PCD: 2027-10-13
Product
long-acting β2-agonists
Product
Atuliflapon
Clinical trial
A Phase 2a, Randomised, Double-Blind, Placebo-Controlled Study to Assess Efficacy and Safety of Atuliflapon Given Orally Once Daily for Twelve Weeks in Adults With Moderate to Severe Uncontrolled Asthma
Status: Recruiting, Estimated PCD: 2025-01-29
Product
Budesonide and Formoterol Fumarate Dehydrate (BF) SPIROMAX
Clinical trial
A Randomised, Double-Blind, Parallel-Group, Placebo-Controlled 28-week Phase 3 Efficacy and Safety Study of Tezepelumab in Reducing Oral Corticosteroid Use in Adults With Oral Corticosteroid Dependent Asthma (SUNRISE)
Status: Recruiting, Estimated PCD: 2025-04-07
Clinical trial
A 12 Week, Randomized, Double-blind, Multicenter, Active Controlled, 2-Arm Parallel Group Study Testing the Superiority of CHF 1535 pMDI 800/24µg Total Daily Dose (Fixed Combination of Extrafine Beclomethasone Dipropionate Plus Formoterol Fumarate) Compared to CHF 718 pMDI 800µg Total Daily Dose (Extrafine Beclomethasone Dipropionate) in Adults With Asthma on Medium or High-Dose Inhaled Corticosteroid
Status: Active (not recruiting), Estimated PCD: 2024-06-01
Product
Beclomethasone Dipropionate
Product
Inhaler CHF5993
Product
Beclomethasone Dipropionate + Formoterol Fumarate
Product
Budesonide and Formoterol Fumarate Dehydrate
Product
BFF pMDI
Clinical trial
A 26 Week, Randomized, Double Blind, Multinational, Multicenter, Active Controlled, 2-arm Parallel Group Trial Comparing CHF 5993 100/6/12.5 μg pMDI (Fixed Combination of Extrafine Formulation of Beclometasone Dipropionate Plus Formoterol Fumarate Plus Glycopyrronium Bromide) to CHF 1535 200/6 μg pMDI (Fixed Combination of Extrafine Formulation of Beclometasone Dipropionate Plus Formoterol Fumarate) in Subjects With Asthma Uncontrolled on Medium Doses of Inhaled Corticosteroids in Combination With Long-Acting β2-Agonists.
Status: Active (not recruiting), Estimated PCD: 2024-04-01
Product
BGF MDI
Product
Pressurized Metered Dose Inhaler (pMDI)
Product
Administration via pressurized metered dose inhaler (pMDI)
Clinical trial
A Regional, Multicentre, Randomized, Double-Blind, Placebo Controlled, Parallel Group, Phase 3 Study to Evaluate the Efficacy and Safety of Tezepelumab in Adults With Severe Uncontrolled Asthma
Status: Active (not recruiting), Estimated PCD: 2024-05-29
Product
Standardised allergen extract
Clinical trial
A 3 Period, Double-Blind, Randomized Crossover Study to Evaluate the Effects of a Single Dose of Montelukast Compared With Placebo on Exercise-Induced Bronchoconstriction as Assessed by Hyperpolarized Gas Magnetic Resonance Imaging.
Status: Completed, Estimated PCD: 2008-10-01
Product
Comparator
Clinical trial
An 8 Week Multicenter, Open-label, Observational Study to Evaluate the Effectiveness of Adding Montelukast Sodium 10 mg Per Day to Inhaled Corticosteroids in Adult Subjects With Uncontrolled Asthma
Status: Completed, Estimated PCD: 2007-09-01
Clinical trial
A Long-term Extension Study to Evaluate the Long-term Safety, Tolerability, and Efficacy of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma Who Completed Treatment Period of Previous Amlitelimab Asthma Clinical Study
Status: Recruiting, Estimated PCD: 2029-06-25
Clinical trial
A Randomized, Double-Blind, Parallel Group, Multicenter 12 Week Study to Assess the Efficacy and Safety of Budesonide and Formoterol Fumarate Metered Dose Inhaler Relative to Budesonide Metered Dose Inhaler in Participants With Inadequately Controlled Asthma (LITHOS)
Status: Recruiting, Estimated PCD: 2024-09-27
Product
BD MDI 160 μg BID
Product
Amlitelimab
Product
PT027
Product
PT007
Clinical trial
A Phase 4, Multicenter, Randomized, Double-blind, Parallel Group, Placebo Controlled Study to Evaluate the Effect of Benralizumab on Structural and Lung Function Changes in Severe Eosinophilic Asthmatics
Status: Recruiting, Estimated PCD: 2026-09-09
Product
Benralizumab
Clinical trial
A Phase 1/2a Study Evaluating the Effects of ARO-RAGE Inhalation Solution in Healthy Subjects and Patients With Inflammatory Lung Disease
Status: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
ALTA - ALbuterol/Budesonide Treatment in Acute Airway Obstruction. A Randomized, Double-blind, 2-period, Cross-over Study Evaluating Efficacy and Safety of Repeated Doses of PT027 Compared to PT007 in Patients With Asthma and Acute Airway Obstruction Induced by Repeated Mannitol Challenges
Status: Recruiting, Estimated PCD: 2024-11-05
Product
I.V. Magnesium Sulfate
Product
TEV-56248
Clinical trial
A Randomized, Double-Blind, Multicenter, Active-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of Fluticasone Propionate/Albuterol Sulfate Fixed-Dose Combination on Severe Asthma Exacerbations in Patients With Asthma
Status: Recruiting, Estimated PCD: 2026-07-17
Clinical trial
A Multicentre, Randomised, Double-Blind, Parallel-Group Placebo-Controlled, Phase 3, Efficacy and Safety Study of Tezepelumab in 5 to < 12 Year Old Children With Severe Uncontrolled Asthma (HORIZON)
Status: Recruiting, Estimated PCD: 2027-04-23
Clinical trial
A Phase 1/2a Study Evaluating the Effects of ARO-MUC5AC Inhalation Solution in Healthy Subjects and Patients With Muco-Obstructive Lung Disease
Status: Recruiting, Estimated PCD: 2024-11-01
Product
ARO-MUC5AC
Clinical trial
Efficacy and Safety of Benralizumab in Paediatric Patients With Severe Eosinophilic Asthma (DOMINICA)
Status: Recruiting, Estimated PCD: 2030-05-05
Product
GSK3511294
Clinical trial
A 52-week, Randomised, Double-blind, Double-dummy, Parallel Group, Multi-centre, Non-inferiority Study Assessing Exacerbation Rate, Additional Measures of Asthma Control and Safety in Adult and Adolescent Severe Asthmatic Participants With an Eosinophilic Phenotype Treated With GSK3511294 Compared With Mepolizumab or Benralizumab
Status: Recruiting, Estimated PCD: 2025-09-26
Product
Standard of care
Clinical trial
A Randomized, Double-blind, Head-to-head Comparison of Dupilumab Versus Omalizumab in Severe Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) and Comorbid Asthma Patients
Status: Recruiting, Estimated PCD: 2025-01-15
Product
Mepolizumab
Clinical trial
BURAN: Effects of Benralizumab on Airway Dynamics in Severe Eosinophilic Asthma Using Functional Respiratory Imaging Parameters
Status: Active (not recruiting), Estimated PCD: 2024-07-31
Product
Omalizumab
Clinical trial
A Phase 2, Randomized, Double-blind, Placebo-controlled, Dose Ranging Study to Assess the Efficacy and Safety of Rocatinlimab in Adult Subjects With Moderate-to-severe Asthma
Status: Not yet recruiting, Estimated PCD: 2026-08-10
Product
SHR-4597
Clinical trial
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Ascending Dose of SHR-4597 Inhalation in Healthy Subjects and Asthmatic Patients
Status: Not yet recruiting, Estimated PCD: 2024-12-01
Clinical trial
A Sequential, 3-Part, Double-Blind, Randomized, Placebo-Controlled, Single-Rising-Dose and Rising-Multiple-Dose Study in Healthy Subjects and Mild or Moderate Asthmatic Patients to Evaluate the Safety, Tolerability, and Pharmacokinetics of Inhaled MK-0476
Status: Completed, Estimated PCD: 2008-09-01
Clinical trial
A Phase 4, 52-week (Primary Analysis at 24-weeks), Randomized, Stratified, Open-label, Active-controlled, Parallel-group, Effectiveness Study, Comparing FF/UMEC/VI With Non-ellipta Usual Care (ICS/LABA) in Adult Participants With Uncontrolled Asthma
Status: Not yet recruiting, Estimated PCD: 2026-03-11
Product
Fluticasone furoate/Umeclidinium bromide/Vilanterol trifenatate
Product
Inhaled corticosteroids + Long-acting beta-2 agonists
Product
AZD4604
Clinical trial
A Phase 2a Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of AZD4604 Twice Daily for Twelve Weeks in Adult Patients With Moderate-to-Severe Asthma Uncontrolled on Medium-High Dose ICS-LABA
Status: Recruiting, Estimated PCD: 2025-09-30
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose Ranging Study to Assess the Efficacy, Safety, and Tolerability of Subcutaneous Lunsekimig in Adult Participants With Moderate-to-severe Asthma
Status: Recruiting, Estimated PCD: 2026-06-30
Product
Rocatinlimab
Product
Lunsekimig
Clinical trial
A Phase 2, Randomized, Double-blind, Placebo-controlled, Multi-center, Dose-ranging Study to Evaluate the Efficacy and Safety of Verekitug (UPB-101) in Adult Participants With Severe Asthma (VALIANT)
Status: Recruiting, Estimated PCD: 2026-02-19
Product
Verekitug
Product
Long-acting β2-agonists (LABA)
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Efficacy, Safety, and Tolerability of Dexpramipexole Administered Orally for 24 Weeks in Participants With Eosinophilic Asthma
Status: Recruiting, Estimated PCD: 2025-03-01
Product
Salbutamol HFA-134a
Product
MRx-4DP0004
Clinical trial
A First in Human, Double-blind, Placebo-controlled, Multicentre Phase I/II Study to Evaluate the Safety, Tolerability and Immune Modulatory Effects of MRx-4DP0004 in Participants Taking Long-term Control Medication for Their Asthma
Status: Terminated, Estimated PCD: 2023-04-26
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Assess the Efficacy, Safety, and Tolerability of Dexpramipexole Administered Orally for 52 Weeks in Participants With Severe Eosinophilic Asthma
Status: Recruiting, Estimated PCD: 2026-06-01
Clinical trial
An Open-Label, Two-Part Sequential Study Designed to Assess the Mass Balance Recovery, Absorption, Metabolism, Excretion of [14C]AZD4604 and the Absolute Bioavailability of AZD4604 in Healthy Male and Female Subjects
Status: Active (not recruiting), Estimated PCD: 2024-05-24
Product
Mometasone Furoate/Formoterol
Product
Mometasone Furoate
Product
Albuterol/Salbutamol HFA MDI
Product
Prednisone/prednisolone
Clinical trial
A Multicentre, Single-arm, Phase 3b Efficacy and Safety Study of Tezepelumab 210 mg Administered Subcutaneously to Reduce Oral Corticosteroid Use in Adult Participants With Severe Asthma on High-dose Inhaled Corticosteroid Plus Long-acting β2 Agonist and Long-term Oral Corticosteroid Therapy (WAYFINDER)
Status: Active (not recruiting), Estimated PCD: 2024-09-12
Product
Fluticasone furoate + Umeclidinium bromide + Vilanterol trifenatate
Product
Budesonide and formoterol fumarate dehydrate (BF)
Product
BGF MDI 320/14.4/9.6 μg
Clinical trial
A Multicenter, Single-arm, Open-label, Post-Authorization, Phase 4 Effectiveness and Safety Study of Tezepelumab in Adult and Adolescent Participants With Severe Asthma Including Several Under-Studied Populations in the United States (PASSAGE)
Status: Recruiting, Estimated PCD: 2025-07-08
Clinical trial
Phase 3, Multicenter, Randomized, Parallel-Group, Open-Label, Comparative Non-Inferiority Fixed-Dose Combination Formoterol 6 mcg/Fluticasone 125 mcg Versus Alenia® (Formoterol 6 mcg/Budesonide 200 mcg) in the Treatment of Moderate Asthma
Status: Not yet recruiting, Estimated PCD: 2025-06-30
Product
Administration of comparator
Clinical trial
Effects of Beclometasone Dipropionate/Formoterol Fumarate Fixed Combination Administered With the NEXT(Haler) in a Real-world Study on the Probability of Improving the Asthma Control Status After 6 Months of Treatment. The NEWTON Study
Status: Active (not recruiting), Estimated PCD: 2024-01-31
Clinical trial
A Randomized, Double-blinded, Single-dose, 3-arm Parallel Comparative Study on Pharmacokinetics and Safety of BAT2606 Injection Versus Mepolizumab Injection (EU-licensed Nucala® and US-licensed Nucala®) in Healthy Chinese Male Subjects
Status: Completed, Estimated PCD: 2023-05-26
Clinical trial
A Single-blind, Randomized, Placebo-controlled 3 Part Study in Healthy Volunteers and Patients With Mild Asthma to Investigate the Safety, Tolerability, and Pharmacokinetics of Inhaled AZD4604 Following Single and Multiple Ascending Doses and to Investigate the Anti-inflammatory Effect of Inhaled AZD4604
Status: Completed, Estimated PCD: 2023-01-24
Clinical trial
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Parallel Group Study to Evaluate the Safety and Efficacy of AVTX-002 for the Treatment of Poorly Controlled Non-Eosinophilic Asthma
Status: Completed, Estimated PCD: 2023-05-11
Clinical trial
A Phase 4, Open-label, Single Arm, 24-week, Study to Evaluate the Safety and Efficacy of Mepolizumab 100 mg SC Administered Every 4 Weeks in Indian Participants Aged ≥18 Years With Severe Eosinophilic asthMa (PRISM)
Status: Recruiting, Estimated PCD: 2023-11-24
Clinical trial
A 52-week, Randomised, Double Blind, Multicentre, 2-arm Parallel Group Trial Assessing Efficacy of CHF6001 (Total Daily Dose 3200μg) Dry Powder Inhaler (DPI) add-on to Maintenance Medium or High Dose of Inhaled Corticosteroids in Combination With Long-acting ß2-agonists in Subjects With Uncontrolled Asthma
Status: Recruiting, Estimated PCD: 2025-12-18
Product
CHF6001
Clinical trial
A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter Variable Length Study to Assess the Efficacy and Safety of PT010 Relative to PT009 and Symbicort® in Adult and Adolescent Participants With Inadequately Controlled Asthma
Status: Recruiting, Estimated PCD: 2025-03-21
Product
Standardised Allergen Extract
Product
AVTX-002
Clinical trial
A Randomized, Double-blind, Placebo-controlled Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Multiple Ascending Doses of CM326 Injection by Subcutaneous Administration in Healthy Subjects
Status: Completed, Estimated PCD: 2022-10-11
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel Group Study to Assess the Efficacy and Longterm Safety of Dupilumab in Children 2 to <6 Years of Age With Uncontrolled Asthma and/or Recurrent Severe Asthmatic Wheeze
Status: Recruiting, Estimated PCD: 2028-12-21
Product
Budesonide + Albuterol sulfate metered-dose inhaler 160/180 μg
Product
Budesonide + Albuterol Sulfate
Product
Albuterol sulfate metered-dose inhaler
Clinical trial
An Open-label, Single Dose Study to Investigate the Pharmacokinetics, Safety, Tolerability and Immunogenicity of Two Dose Levels of GSK3511294 Administered Subcutaneously in Chinese Healthy Participants
Status: Completed, Estimated PCD: 2022-12-23
Product
Buventol Easyhaler
Clinical trial
A Randomized, Double Blind, Parallel Group Study of the Efficacy and Safety of Mepolizumab as Adjunctive Therapy in Patients With Severe Asthma With Eosinophilic Inflammation
Status: Completed, Estimated PCD: 2022-09-07
Clinical trial
Placebo-Controlled Proof of Concept Study to Investigate ANB020 Activity in Adult Patients With Severe Eosinophilic Asthma
Status: Completed, Estimated PCD: 2018-10-30
Product
SHR-1703
Clinical trial
Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of a Single Subcutaneous Injection of SHR-1703 in Patients With Asthma -- a Randomized, Double-blind, Dose-increasing, Placebo Controlled Phase I Clinical Study
Status: Active (not recruiting), Estimated PCD: 2023-06-15
Product
Etokimab
Clinical trial
Use of Buventol Easyhaler and Bufomix Easyhaler as Relievers in Methacholine Challenge Testing and Inspiratory Flow Profiles During Induced Bronchoconstriction in Adult Subjects
Status: Completed, Estimated PCD: 2023-06-30
Product
Bufomix Easyhaler
Clinical trial
Prospective, Randomised, DBPC, Double-dummy, Multicenter CT of Efficacy and Safety With IT in Patients With Controlled Mild to Moderate Allergic Asthma and Rhinitis/Rhinoconjunctivitis, Allergic to D. Pteronyssinus and/or D. Farinae.
Status: Not yet recruiting, Estimated PCD: 2024-07-01
Product
MM09 allergoid-mannan conjugates
Product
SHR-1819
Product
Ventoline
Clinical trial
A Phase 1, First-in-Human, Double-Blind, Placebo-Controlled Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of SM17 When Administered Intravenously as a Single Ascending Dose in Healthy Subjects (Part A) and as Multiple Ascending Doses in Healthy Subjects (Part B)
Status: Recruiting, Estimated PCD: 2023-09-01
Clinical trial
A Phase 1, Randomized, Double-blind, Placebo-controlled, Single and Multiple Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Subcutaneous Administered SHR-1819 in Healthy Subjects
Status: Completed, Estimated PCD: 2021-12-10
Product
Fluticasone propionate
Clinical trial
A Phase III, Randomized, Multicenter, Parallel-group Clinical Trial for Examining the Therapeutic Equivalence Between Fluticasone Propionate 100 mcg/Blister Oral Inhalation Powder/Respirent Pharmaceuticals vs. FLOVENT DISKUS® 100 mcg/Blister Oral Inhalation Powder/GSK in Patients With Asthma
Status: Completed, Estimated PCD: 2021-08-13
Product
SHR-1905
Clinical trial
A Multicentre, Randomized, Double-blind, Placebo-controlled, Parallel Group, Phase 2 Study to Evaluate the Efficacy and Safety of SHR-1905 in Subjects With Severe Uncontrolled Asthma.
Status: , Estimated PCD: 2024-10-31
Clinical trial
An Open-Label Extension Study of Reslizumab 110-mg Fixed, Subcutaneous Dosing in Patients 12 Years of Age and Older With Severe Eosinophilic Asthma
Status: Terminated, Estimated PCD: 2018-02-22
Clinical trial
A Phase II, Multicenter, Randomized, Double-Blind, Parallel-Group, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lyophilized and Aged Liquid Omalizumab in the Prevention of Allergen-Induced Airway Obstruction in Adults With Mild Allergic Asthma
Status: Completed, Estimated PCD: 2009-02-01
Clinical trial
A Phase 2, Multicenter, Randomized, Double Blind, Placebo Controlled, Parallel Group Study to Assess the Safety, Efficacy and Pharmacodynamics of TEV 53275 Administered Subcutaneously in Adult Patients With Persistent Eosinophilic Asthma
Status: Terminated, Estimated PCD: 2022-04-28
Product
TEV-53275
Product
FLOVENT DISKUS
Product
BDP/FF NEXThaler
Clinical trial
Assessing the Efficacy of Antipyrine Benzocaine Otic Solution in the Ear Canal to Decrease Usage of Rescue Inhalers in Moderate to Severe Asthmatic Adults.
Status: Not yet recruiting, Estimated PCD: 2023-08-01
Clinical trial
A Randomized, Double-blind, Dose-escalation Phase I Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics of 9MW1911 Injection in Healthy Subjects
Status: Active (not recruiting), Estimated PCD: 2023-06-01
Product
Placebo for AZD4604
Product
Antipyrine-benzocaine
Product
MSTT1041A
Clinical trial
A Phase IIb, Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Ranging Study to Assess the Efficacy and Safety of MSTT1041A in Patients With Uncontrolled Severe Asthma
Status: Completed, Estimated PCD: 2019-04-05
Clinical trial
A Multicenter, Randomized, Double-blind, Placebo-controlled Phase Ib Study to Determine the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Recombinant Anti-IL-5 Humanized Monoclonal Antibody Therapy in Adult Subjects With Severe Eosinophilic Asthma
Status: Active (not recruiting), Estimated PCD: 2023-09-01
Product
9MW1911
Clinical trial
CONNected Electronic Inhalers Asthma Control Trial 2 ("CONNECT 2"), a 24-Week Treatment, Multicenter, Open-Label, Randomized, Parallel Group Comparison, Feasibility Study of Standard of Care Treatment Versus the eMDPI Digital System, to Optimize Outcomes in Patients at Least 13 Years of Age or Older With Asthma
Status: Completed, Estimated PCD: 2022-03-04
Product
Standard of Care Asthma Medication
Product
Standard of Care Rescue Medication
Product
reslizumab
Product
omalizumab
Clinical trial
A RDPC, Prospective, Multicenter Clinical Trial to Evaluate the Efficacy and Safety of SCIT in Patients With Rhinitis With or Without Mild to Moderate Asthma Sensitized to Cupressaceae and Grasses.
Status: Recruiting, Estimated PCD: 2023-12-01
Product
XKH001
Clinical trial
A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of Brodalumab in Subjects With Inadequately Controlled Asthma and High Bronchodilator Reversibility
Status: Terminated, Estimated PCD: 2015-05-15
Product
610 300mg
Product
Fluticasone propionate/salmeterol
Clinical trial
A Single-dose, Randomised, Double-blind, Controlled, 2-way Cross-over Study to Assess the Potential for Bronchoconstriction of the New Propellant HFA-152a Versus the Marketed HFA-134a Propellant, in Adult Subjects With Mild Asthma
Status: Completed, Estimated PCD: 2022-10-31
Product
Mometasone furoate
Clinical trial
An Open-label, Two-period, Single-sequence, Crossover Study to Compare the Systemic Exposure of a Single Inhaled Dose of Mometasone Furoate (MF) When Administered Alone Via the MF Twisthaler® (TH) to a Single Inhaled Dose of QMF149 Indacaterol Acetate/MF Fixed Dose Combination When Administered Via the Concept 1 (C1) Breezhaler® Device in ≥ 6 to < 12 Year Old Asthma Patients
Status: Completed, Estimated PCD: 2022-04-11
Product
Standard of Care
Clinical trial
An Open-label Study to Evaluate the Pharmacokinetics and Pharmacodynamics and Long-term Safety of Benralizumab Administered Subcutaneously in Children With Severe Eosinophilic Asthma
Status: Completed, Estimated PCD: 2022-09-12
Clinical trial
A Multicenter,Randomized,Double-blind, Placebo-controlled Phase II Clinical Trial to Evaluate the Efficacy and Safety of TQC2731 Injection in Patients With Poorly Controlled Severe Asthma
Status: Recruiting, Estimated PCD: 2024-10-01
Product
AZD1402
Clinical trial
A Two-part Phase IIa Randomised, Double-blind, Placebo-controlled, Dose-ranging, Multi-centre Study to Assess Efficacy and Safety of Inhaled AZD1402 Administered as a Dry Powder for Four Weeks in Adults With Asthma on Medium-to-High Dose Inhaled Corticosteroids
Status: Terminated, Estimated PCD: 2023-07-20
Clinical trial
The Effect of FP-025, a MMP-12 Inhibitor, on Allergen-induced Airway Responses, Airway Inflammation and Aspects of Airway Remodeling in Subjects With Mild Eosinophilic House Dust Mite (HDM)-Allergic Asthma (HDM)-Allergic Asthma
Status: Completed, Estimated PCD: 2022-12-30
Product
Brodalumab
Product
MM09 allergoid-mannan conjugates subcutaneous
Product
EDP1867
Clinical trial
A Ph1a/1b, First in Human, Participant and Investigator-blind Sponsor-unblinded Randomized Placebo-controlled Multiple Dose Study of EDP1867 in Healthy Volunteers & Participants With Moderate Atopic Dermatitis & Optionally, Moderate Psoriasis, and/or Mild Asthma
Status: Completed, Estimated PCD: 2022-02-28
Clinical trial
A Multicenter, Open-label Study to Evaluate the Sensitivity and Specificity of Inhaled Methacholine in Bronchial Provocation Test
Status: , Estimated PCD: 2023-02-01
Clinical trial
Randomized, Double-blinded, Placebo-controlled, Prospective, Multicenter Trial to Evaluate the Efficacy and Safety of SIC in Subjects With Mild/Moderate Asthma and Rhinitis/Rhinoconjunctivitis Sensitized to D.Pteronyssinus and/or D. Farinae
Status: Recruiting, Estimated PCD: 2024-01-01
Product
10,000 MM09
Product
30,000 MM09
Clinical trial
A Randomized, Double Blind, Placebo-controlled, Parallel-group Phase 3 Study to Evaluate the Efficacy and Safety of Dupilumab in Patients With Persistent Asthma
Status: Completed, Estimated PCD: 2022-05-21
Product
Asthma Controller Therapies
Product
Asthma Reliever Therapies
Product
Depemokimab
Product
BI 894416
Clinical trial
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Single Rising Oral Doses and Multiple Rising Oral Doses of BI 894416 Versus Placebo in Male Patients With Asthma (Single-blind, Randomised, Placebo-controlled, Parallel Group Design).
Status: Completed, Estimated PCD: 2020-10-26
Product
HBM9378
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Single-ascending-dose Phase I Clinical Study in Healthy Chinese Subjects to Evaluate the Safety, Tolerability and Pharmacokinetics of HBM9378 (SKB378) After Subcutaneous Administration.
Status: Recruiting, Estimated PCD: 2023-09-22
Product
ADX-629
Clinical trial
A Double Masked, Placebo Controlled, Single Center, Randomized Clinical Trial to Assess the Safety and Efficacy of ADX-629 in Subjects With Mild Asthma Induced by the Bronchial Allergen Challenge (BAC)
Status: Completed, Estimated PCD: 2022-01-18
Clinical trial
A Randomised, Double Blind, Placebo Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of SHR-1703 Injection Administered Subcutaneously in Healthy Subjects
Status: Completed, Estimated PCD: 2021-09-21
Product
FP-025
Product
Placebo FP-025
Product
Short acting beta agonist (SABA)
Product
Run-in medications
Clinical trial
A Randomized, Double-blind, Positive and Placebo-controlled, Single-dose, Crossover Study of the Effects of CHF5993 pMDI (BDP/FF/GB) at the Proposed Therapeutic and Supratherapeutic Doses, on the Cardiovascular Safety in Healthy Subjects
Status: Completed, Estimated PCD: 2023-10-13
Product
TEV-48574
Clinical trial
A 16-Week, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group, Proof-of-Concept Study to Evaluate the Efficacy and Safety of TEV-48574 in Adults With T2-low/Non-T2 Severe Uncontrolled Asthma
Status: Terminated, Estimated PCD: 2022-01-17
Clinical trial
A Phase III, 12 Week, Randomized, Double-blind, 4 Arm Parallel Group Bridging Study, Comparing the Efficacy, Safety and Tolerability of the Fixed Dose Combination FF/UMEC/VI Once-daily Via a Dry Powder Inhaler With Dual Combination of FF/VI, Administered in Chinese Participants With Inadequately Controlled Asthma
Status: Recruiting, Estimated PCD: 2024-09-30
Clinical trial
SHAMAL: A Multicentre, Randomised, Open-Label, Parallel-Group, Active-Controlled, Phase IV Study to Assess the Reduction of Daily Maintenance ICS/LABA Treatment Towards Anti-Inflammatory Reliever Treatment in Patients With Severe Eosinophilic Asthma Treated With Benralizumab
Status: Completed, Estimated PCD: 2023-01-31
Product
Fasenra®
Product
CHF 5993 BDP/FF/GB
Clinical trial
A Single Dose, Randomized, Open-label, 3-Way Cross-over Clinical Pharmacology Study, to Evaluate the Systemic Exposure of BDP, Beclomethasone 17-monoproprionate, Formoterol Fumarate, and Glycopyrronium Bromide, After Inhalation of the Fixed Combination BDP/FF/GB HFA pMDI (CHF 5993) at Two Different Strengths and of BDP Hydrofluoroalkane (HFA), in Healthy Volunteers.
Status: Recruiting, Estimated PCD: 2023-08-03
Product
BDP HFA
Product
AQ001S
Product
Symbicort®
Product
CHF 5993
Product
Budesonide/Formoterol
Product
SYMBICORT
Clinical trial
A 12-Week Efficacy and Safety Evaluation of Budesonide/Formoterol SPIROMAX(R) 160/4.5 mcg Inhalation Powder Versus SYMBICORT(R) TURBOHALER(R) 200/6 mcg in Adult and Adolescent Patients With Persistent Asthma
Status: Completed, Estimated PCD: 2014-03-20
Product
ARRY-502
Clinical trial
A Phase 2 Randomized, Double-blind, Placebo-controlled, Parallel-group, Multicenter Study to Evaluate the Efficacy and Safety of ARRY-502 in Adults With Persistent Asthma
Status: Completed, Estimated PCD: 2013-05-31
Clinical trial
A Phase 1, Randomized, Double-Blind, Placebo-Controlled Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Immunogenicity of Single Subcutaneous Administered SHR-1905 in Healthy Subjects
Status: Completed, Estimated PCD: 2022-11-12
Clinical trial
A 24-week Randomised Exploratory Open-Label Study Aiming To Characterise Changes In Airway Inflammation, Symptoms, Lung Function, And Reliever Use In Asthma Patients Using SABA (Salbutamol) Or Anti-Inflammatory Reliever (SYMBICORT®) As Rescue Medication In Addition To SYMBICORT As Daily Asthma Controller
Status: Completed, Estimated PCD: 2022-12-16
Clinical trial
A 12-week, Randomized, Double-blind, Placebo-controlled, Multicenter, Parallel Group, Phase III Study Evaluating the Efficacy and Safety of PT027 Compared to PT008 and PT007 Administered QID in Adults and Children 4 Years of Age or Older With Asthma
Status: Completed, Estimated PCD: 2021-07-20
Product
Albuterol sulfate metered dose inhaler
Clinical trial
A 12-week, Multicenter, Randomized, Double-blind, Parallel-arm, Placebo-controlled Study to Assess the Efficacy and Safety of CSJ117, When Added to Existing Asthma Therapy in Patients ≥ 18 Years of Age With Severe Uncontrolled Asthma.
Status: Terminated, Estimated PCD: 2022-07-12
Clinical trial
One Year Study to Evaluate the Long-term Safety and Tolerability of Dupilumab in Pediatric Patients With Asthma Who Participated in a Previous Dupilumab Asthma Clinical Study
Status: Active (not recruiting), Estimated PCD: 2025-03-31
Product
Asthma controller therapies
Clinical trial
A Randomized, Double-Blind, Placebo-Controlled Dose-Ranging Biomarker Study of the Effects of Dexpramipexole on Eosinophils in Subjects With Eosinophilic Asthma
Status: Completed, Estimated PCD: 2020-12-03
Clinical trial
Phase III Therapeutic Evaluation Study Comparing the Efficacy and Safety of the Fluticasone/Salmeterol (500/50 μg) Combination Administered With Elpenhaler® (Rolenium®) Versus the Innovative One (Seretide Diskus®) in Patients With Asthma.
Status: Completed, Estimated PCD: 2008-08-01
Product
Elpenhaler
Clinical trial
A Phase 1, Randomized, Double-blind, Placebo-controlled, Multiple Ascending-Dose Study to Assess the Safety, Tolerability, Immunogenicity, Pharmacokinetics and Pharmacodynamics of UPB-101 in Subjects With Asthma
Status: Completed, Estimated PCD: 2023-08-15
Product
10,000 MG01 + 10,000 T517
Clinical trial
A Randomized, Double-Blinded, Placebo-Controlled, Prospective, Multicenter CT to Evaluate Efficacy and Safety of Subcutaneous Immunotherapy in Subjects With Rhinitis With/Without Mild to Moderate Asthma Sensitized to Olive and Grass Pollen
Status: Recruiting, Estimated PCD: 2025-10-01
Clinical trial
A Single Dose Two-way Cross-over Study in Healthy Participants to Compare the Pharmacokinetics (PK) of Salbutamol Administered Via Metered Dose Inhalers Containing Propellants HFA-152a and HFA-134a
Status: Completed, Estimated PCD: 2023-05-21
Clinical trial
A Phase 2 Multicenter, Double-blind, Randomized, Placebo-Controlled Trial to Evaluate Oral Ifetroban in Subjects With Symptomatic Aspirin Exacerbated Respiratory Disease (AERD)
Status: Active (not recruiting), Estimated PCD: 2024-04-01
Clinical trial
Comparative Real World Effectiveness of SQ Sublingual Immunotherapy (SLIT)-Tablets vs. Controls in Allergic Rhinitis and Asthma - Outcomes From a Multinational Register Study
Status: Active (not recruiting), Estimated PCD: 2024-06-01
Clinical trial
Prospective, Randomised, DBPC Clinical Trial to Evaluate the Efficacy and Safety of Polymerized and Mannan Conjugated Allergen Extract of Dermatophagoides for the Treatment of Allergic Rhinitis/Rhinoconjunctivitis With or Without Asthma
Status: Not yet recruiting, Estimated PCD: 2026-06-01
Clinical trial
A Phase I, Randomized, Blinding, Single-dose, Placebo Control Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics Effect of GR2002 in Chinese Health Volunteers
Status: Recruiting, Estimated PCD: 2023-11-30
Product
AZD8630
Clinical trial
Phase I, Randomised, Blinded, Placebo-controlled Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AZD8630 in Healthy Adult Subjects (Part A) and Adults With Asthma on Medium to High Dose Inhaled Corticosteroids and Long-acting Beta-agonists (Part B)
Status: Completed, Estimated PCD: 2023-08-02
Product
Budesonide + Formoterol Fumarate
Clinical trial
A 52-week, Randomised, Double-blind, Placebo-controlled, Parallel-group, Multi-centre Study of the Efficacy and Safety of GSK3511294 Adjunctive Therapy in Adult and Adolescent Participants With Severe Uncontrolled Asthma With an Eosinophilic Phenotype
Status: Active (not recruiting), Estimated PCD: 2024-04-09
Clinical trial
Randomized, DB, Crossover Study to Assess Bronchospasm Potentially Induced by HFO MDI vs. HFA MDI Propellant in Participants With Asthma Well/Partially Controlled on SABA With or Without Low-Dose ICS
Status: Completed, Estimated PCD: 2023-08-21
Clinical trial
A Multicenter, Randomized, Double-blind, Parallel Group, Placebo-controlled, Phase 3b Study to Evaluate the Potential Effect of Tezepelumab on the Humoral Immune Response to Seasonal Quadrivalent Influenza Vaccination in Adolescent and Young Adult Participants With Moderate to Severe Asthma (VECTOR)
Status: Completed, Estimated PCD: 2022-03-21
Product
HFA
Product
HFO MDI
Product
SAR443765
Clinical trial
A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single and Multiple Ascending Doses of SAR443765 in Healthy Adult Participants and of a Single Dose of SAR443765 in Participants With Mild-to-moderate Asthma
Status: Completed, Estimated PCD: 2023-02-24
Clinical trial
Multicenter Randomized Parallel-Group 6-Week Treatment Clinical Study to Assess BE of Budesonide 80 μg and Formoterol Fumarate Dihydrate 4.5 μg Inhalation Product in Comparison With Reference Product, Symbicort® in Adult Asthma Patients
Status: Completed, Estimated PCD: 2023-08-15
Product
Glycopyrronium bromide
Clinical trial
A Phase II, Double-blind, Randomized, Multiple Dose, Cross Over, Three-treatment, Three-period, Six Sequence Placebo Controlled Trial to Evaluate Efficacy, Pharmacokinetics (PK), Pharmacodynamics (PD) and Safety and Tolerability of Glycopyrronium (Bromide) in Children From 6 to Less Than 12 Years of Age With Asthma.
Status: Recruiting, Estimated PCD: 2025-05-09
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose Ranging Study to Assess the Efficacy, Safety, and Tolerability of Subcutaneous Amlitelimab in Adult Participants With Moderate-to-severe Asthma
Status: Active (not recruiting), Estimated PCD: 2024-10-04
Clinical trial
A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase II Clinical Study to Evaluate the Pharmacodynamic, Efficacy and Safety of Multiple Subcutaneous Injections of SHR-1703 in Asthma Patients With Eosinophil Phenotype
Status: Active (not recruiting), Estimated PCD: 2023-12-30
Clinical trial
Benralizumab Patient Access Programme Study: Retrospective, Observational Study in UK Severe Asthma Centres to Describe Patient Characteristics, Treatment Patterns and Outcomes
Status: Completed, Estimated PCD: 2022-02-28
Clinical trial
Multicentre, Prospective, Non-interventional Study Monitoring Therapy Pathways of Asthma Patients Treated With an Extrafine ICS/LABA/LAMA Single-inhaler Triple Therapy in a Real-world Setting and Characterizing the Effects on Health-related Outcomes
Status: Not yet recruiting, Estimated PCD: 2025-10-31
Clinical trial
A Phase II Study to Evaluate the Efficacy and Safety of FB825 in Adult Patients With Moderate-to-severe Allergic Asthma
Status: Recruiting, Estimated PCD: 2024-06-01
Product
Albuterol Sulfate Inhalation Aerosol
Clinical trial
To Compare the Bronchoprotective Effects of the Test and Reference Metered Dose Inhalers (MDIs) Containing Albuterol Sulfate Using Methacholine Bronchoprovocation Challenge Testing in Stable Mild Asthma Patients.
Status: Not yet recruiting, Estimated PCD: 2024-08-12
Clinical trial
5HTP Regulation Of Asthma In Children
Status: Recruiting, Estimated PCD: 2024-12-01
Product
5-Hydroxytryptophan
Clinical trial
Assessment and Prediction of the Effectiveness of Mepolizumab Anti-IL-5/IL5R Inhibitors in a Real-world Setting
Status: Completed, Estimated PCD: 2023-06-13
Product
IL5/IL5R Antagonists
Clinical trial
Hyperpolarized 129Xe MR Imaging of Lung Function in Healthy Volunteers and Subjects With Pulmonary Disease
Status: Recruiting, Estimated PCD: 2025-10-26
Product
Hyperpolarized Xe129
Clinical trial
Comparison Of Efficacy Of Hydrocortisone And Methyl Prednisolone In Acute Severe Asthma
Status: , Estimated PCD: 2024-08-01
Product
Methylprednisolone,
Clinical trial
Predictive Signature of Benralizumab Response
Status: Recruiting, Estimated PCD: 2026-10-01
Clinical trial
A Randomised, Double-blind, Parallel Group, Placebo Controlled, 4-Week, Phase II Study to Evaluate the Effect of AZD4604 on Airway Inflammation and Biomarkers in Adults With Asthma
Status: Not yet recruiting, Estimated PCD: 2026-08-12
Clinical trial
Biomarkers Evaluation and Effect of Mepolizumab on Lower and Upper Airways Inflammation in Severe Refractory Eosinophilic Asthma and Nasal Polyposis
Status: Recruiting, Estimated PCD: 2024-11-01
Clinical trial
Leveraging Pharmacogenomics in Asthma for Predication, Mechanism and Endotyping
Status: Recruiting, Estimated PCD: 2027-06-30
Clinical trial
Methods to Identify and Treat Severe Asthma Patients Project 1: GSNOR Phenotyping and GSNO Challenge
Status: Recruiting, Estimated PCD: 2025-06-30
Product
GSNO
Clinical trial
Real Life Experience Survey of Dupilumab in the Netherlands
Status: Completed, Estimated PCD: 2022-10-30
Clinical trial
Comparison of Parasympathetic Activity in Mild, Moderate, and Severe Asthma With Fixed Airway Obstruction
Status: Recruiting, Estimated PCD: 2024-06-01
Product
Ipratropium Bromide
Product
Salbutamol + Ipratropium Bromide
Clinical trial
Inflammatory Cellular Trafficking in Asthma in Response to Segmental Allergen Challenge
Status: Recruiting, Estimated PCD: 2024-04-30
Product
Bronchoscopy
Clinical trial
A Pilot Study to Assess the Incidence of Local Oropharyngeal and Laryngeal Adverse Effects of Advair DISKUS 250/50 mcg BID as Assessed by the Development of Laryngitis and Oropharyngeal Candidiasis in Adults With Mild Persistent Asthma
Status: Completed
Product
Fluticasone/Salmeterol Diskus
Clinical trial
Characterization of Natural Killer Cells in Severe Asthma Patients in Comparison With Control Subjects: Identification of Biomarkers, Response During Virus-induced Exacerbations, and Interaction With Bronchial Epithelial Cells
Status: Recruiting, Estimated PCD: 2028-09-01
Product
Blood sample
Clinical trial
AZithromycin Therapy in Preschoolers With a Severe Wheezing Episode Diagnosed at the Emergency Department (AZ-SWED)
Status: Recruiting, Estimated PCD: 2025-11-15
Product
Azithromycin
Clinical trial
A Histamine Pharmacodynamic Biomarker to Guide Treatment in Pediatric Asthma
Status: Recruiting, Estimated PCD: 2025-05-01
Product
Levocetirizine
Clinical trial
Clinical Assessment of Jia Wei Yang He Formula as a Plus Therapy in the Treatment of Persistent Asthma and Airway Microbiome Exploration Research
Status: Recruiting, Estimated PCD: 2025-12-01
Product
Jia Wei Yang He
Clinical trial
A 2-Week Double-Blind, Placebo-Controlled, Parallel Group Study Comparing the Anti-Inflammatory Effects of Low, Medium, and High Dose Mometasone Furoate/Formoterol Fumarate MDI Formulation and Medium Dose Mometasone Furoate DPI and MDI Formulations in Adults and Adolescents With Persistent Allergic Asthma
Status: Completed, Estimated PCD: 2009-06-01
Product
Mometasone Furoate + Formoterol 100/10
Product
Mometasone Furoate + Formoterol
Product
MF DPI 200
Product
MF MDI
Clinical trial
Optimisation of Treatment in Patients With CRSwNP. An RCT of Mepolizumab and Surgical Treatment With FESS and Mepolizumab Versus Only Mepolizumab Over a 6- and 12-month Follow-up
Status: Recruiting, Estimated PCD: 2025-01-31
Clinical trial
Obesity & Asthma: Nutrigenetic Response to Omega-3 Fatty Acids
Status: Completed, Estimated PCD: 2016-10-22
Product
Omega-3 Fatty Acid
Clinical trial
A Randomised, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy of Oral Azithromycin (500 Mg OD) as a Supplement to Standard Care for Adult Patients With Acute Exacerbations of Asthma
Status: Completed, Estimated PCD: 2014-06-01
Product
Zithromax
Clinical trial
Metformin IN Asthma for Overweight and Obese Individuals (MINA)
Status: Not yet recruiting, Estimated PCD: 2026-09-30
Product
Metformin
Clinical trial
Safety, Tolerability, and Pharmacokinetics of MG-ZG122 in a Single Subcutaneous Injection in Chinese Healthy Adult Subjects: a Single-center, Randomized, Double-blind, Placebo-controlled, Dose-increasing Phase I Clinical Trial
Status: Active (not recruiting), Estimated PCD: 2024-01-26
Product
MG-ZG122
Clinical trial
Open Label, 12-week Clinical Trial to Assess Efficacy, Safety, Treatment Adherence and Quality of Life Impact of Mometasone Furoate Dry Powder 400 mcg Once-daily in Persistent Mild-moderate Asthmatic Patients at Least 12 Years Old
Status: Terminated, Estimated PCD: 2009-09-01
Product
Mometasone
Product
10,000 MG01
Product
30000 MG01 +10000 T521
Clinical trial
Randomized, Double-Blind, Placebo-Controlled, Parallel Design, Multiple-Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of AMG 157 in Subjects With Mild Atopic Asthma
Status: Completed, Estimated PCD: 2013-04-05
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Multiple Ascending Dose Phase Ib Clinical Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of XKH001 Injection in Healthy Subjects
Status: Not yet recruiting, Estimated PCD: 2024-08-01
Clinical trial
A Long-term, Randomized, Double-blind, Multicenter, Parallel-group, Phase III Study Evaluating the Efficacy and Safety of PT027 Compared to PT007 Administered as Needed in Response to Symptoms in Symptomatic Adults and Children 4 Years of Age or Older With Asthma
Status: Completed, Estimated PCD: 2021-08-19
Product
SM17
Product
TQC2731
Product
Administration of investigation drug
Clinical trial
A 24-week, Multicenter, Randomized, Double-blind, Parallel-arm, Placebo-controlled Extension Study to Assess the Safety of CSJ117, When Added to Existing Standard of Care Asthma Therapy in Patients ≥18 Years of Age
Status: Terminated, Estimated PCD: 2022-09-08
Product
CSJ117
Clinical trial
A Multicentre, Double-blind, Randomized, Placebo Controlled, Parallel Group, Phase 3, Safety Extension Study to Evaluate the Safety and Tolerability of Tezepelumab in Adults and Adolescents With Severe Uncontrolled Asthma (DESTINATION)
Status: Completed, Estimated PCD: 2021-10-26
Clinical trial
PONENTE: A Multicenter, Open-label, Phase 3b Efficacy and Safety Study of Benralizumab 30 mg Administered Subcutaneously to Reduce Oral Corticosteroid Use in Adult Patients With Severe Eosinophilic Asthma on High Dose Inhaled Corticosteroid Plus Long-acting β2 Agonist and Chronic Oral Corticosteroid Therapy
Status: Completed, Estimated PCD: 2021-04-16
Product
AK120
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Multicenter Phase II Clinical Trial to Evaluate the Efficacy and Safety of AK120 in the Treatment of Subjects With Moderate-to-severe Asthma
Status: Terminated, Estimated PCD: 2022-08-05
Product
Methacholine
Clinical trial
A Prospective, Real-World, Interventional Study To Evaluate The Effect Of Mepolizumab On Achieving Clinical Remission In Participants With Severe Asthma
Status: Not yet recruiting, Estimated PCD: 2026-07-27
Clinical trial
CONNected Electronic Inhalers Asthma Control Trial 1 ("CONNECT 1"), a 12-Week Treatment, Multicenter, Open-Label, Randomized, Parallel Group Comparison, Feasibility Study to Evaluate the Effectiveness of the Albuterol eMDPI Digital System, to Optimize Outcomes in Patients at Least 13 Years of Age or Older With Asthma
Status: Completed, Estimated PCD: 2021-10-04
Product
albuterol
Clinical trial
An Open-Label, Randomized, Single-Dose, Multicenter, Parallel-Group Study to Compare the Pharmacokinetics of Subcutaneous Depemokimab When Delivered With a Safety Syringe Device or an Autoinjector in Healthy Adult Participants
Status: Active (not recruiting), Estimated PCD: 2024-01-26
Clinical trial
Randomized, Double Blind, Placebo Controlled Study to Evaluate the Effect of Dupilumab on Airway Inflammation Through Assessments of Lung Function, Mucus Plugging and Other Lung Imaging Parameters in Patients With Asthma
Status: Completed, Estimated PCD: 2023-06-26
Product
FF via ELLIPTA DPI
Clinical trial
A Phase III, Randomized, Multicenter, Parallel-group Clinical Trial for Examining the Therapeutic Equivalence Between Fluticasone Propionate 100 mcg and Salmeterol 50 mcg Inhalation Powder/Respirent Pharmaceuticals vs. ADVAIR DISKUS® 100/50 mcg Inhalation Powder/GSK in Patients With Asthma
Status: Recruiting, Estimated PCD: 2023-07-31
Product
Fluticasone Propionate + Salmeterol
Product
Advair Diskus
Clinical trial
A Randomised, Double-blind, Parallel Group, Multicentre, Stratified, Study Evaluating the Efficacy and Safety of Once Daily Fluticasone Furoate/Vilanterol Inhalation Powder Compared to Once Daily Fluticasone Furoate Inhalation Powder in the Treatment of Asthma in Participants Aged 5 to 17 Years Old (Inclusive) Currently Uncontrolled on Inhaled Corticosteroids
Status: Completed, Estimated PCD: 2022-03-21
Product
Ventolin®
Clinical trial
A Phase 1b, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate Safety and Efficacy of Oral Zavegepant in Subjects With Mild Allergic Asthma
Status: Terminated, Estimated PCD: 2023-03-29
Product
CHF5259
Product
Moxifloxacin
Clinical trial
A Prospective, Active-controlled, Randomized, Open Label, Single-center, Multiple Dose, Crossover Clinical Trial to Assess the Efficacy, Safety and PK of AQ001S Compared to a Budesonide Inhalation Suspension in Adults With Mild Asthma
Status: Completed, Estimated PCD: 2022-12-31
Clinical trial
Open-label, Interventional, Cohort Study to Evaluate Long-term Safety of Dupilumab in Patients With Moderate to Severe Asthma Who Completed the TRAVERSE-LTS12551 Clinical Trial
Status: Completed, Estimated PCD: 2022-02-18
Product
Zavegepant
Clinical trial
A Phase III, Randomized, Multicenter, Double-blind, Two-armed, Parallel, Active-controlled, Equivalency Clinical Trial to Compare Efficacy and Safety of Omalizumab (CinnaGen, Iran) in Comparison to Xolair® (Genentech, Inc., USA And Novartis Pharmaceuticals Corp, Switzerland) in Patients With Uncontrolled Moderate to Severe Allergic Asthma
Status: Completed, Estimated PCD: 2023-01-15
Product
SPIROMAX
Product
Budesonide/Albuterol Sulfate Metered Dose Inhaler
Product
Budesonide + Albuterol Sulfate MDI 80/180 μg
Clinical trial
A Phase I Clinical Study to Evaluate the Safety, Tolerability, Pharmacokinetics Characteristics and Immunogenicity of a Single Dose of 9MW1911 Injection in Healthy Subjects
Status: Completed, Estimated PCD: 2022-07-03
Clinical trial
Post-Authorization Safety Study to Monitor Pregnancy and Infant Outcomes Following Administration of Dupilumab During Planned or Unexpected Pregnancy in North America
Status: Recruiting, Estimated PCD: 2026-07-09
Product
dupilumab
Product
MTPS9579A
Clinical trial
A Phase IIa, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of MTPS9579A in Patients With Asthma Requiring Inhaled Corticosteroids and a Second Controller
Status: Completed, Estimated PCD: 2022-05-19
Clinical trial
An Open-label, Single Arm, Repeat Dose, Multi-centre Study to Evaluate the Use of an Autoinjector for the Subcutaneous Administration of Mepolizumab in Subjects With Severe Eosinophilic Asthma (Study 204959)
Status: Completed, Estimated PCD: 2017-11-30
Clinical trial
Registry of Asthma Patients Initiating DUPIXENT® (RAPID)
Status: Active (not recruiting), Estimated PCD: 2026-07-07
Product
DUPIXENT®
Product
UPB-101
Product
30000 MG01 + 10000 T517
Product
3,000 MM09
Product
MM09
Clinical trial
A Multi-centre, Single Arm, Open-label Extension Study to Evaluate the Long-term Safety of GSK3511294 (Depemokimab) in Adult and Adolescent Participants With Severe Asthma With an Eosinophilic Phenotype From Studies 206713 or 213744
Status: Recruiting, Estimated PCD: 2025-05-07
Clinical trial
MEA115666: A Multi-centre, Open-label, Long Term Safety Study of Mepolizumab in Asthmatic Subjects Who Participated in the MEA112997 Trial
Status: Completed, Estimated PCD: 2017-05-31
Product
Ifetroban
Product
SQ SLIT
Product
GR2002
Clinical trial
A 12-week, Multicenter, Randomized, Double-blind, Double-dummy, 2-arm Parallel Group Study Comparing the Efficacy and Safety of Foster 100/6mg NEXThaler, 2 Inhalations b.i.d, Versus Foster 100/6mg pMDI, 2 Puffs b.i.d in Patients With Controlled Asthma
Status: Completed, Estimated PCD: 2021-12-28
Product
Foster
Product
Foster 100/6mg
Product
BDP/FF/G
Product
FB825
Product
Ventolin HFA
Product
Pressurized Metered Dose Inhaler
Clinical trial
Nasal Endotoxin Challenge to Study Mucosal Inflammation in Patients With Asthma
Status: Not yet recruiting, Estimated PCD: 2028-04-01
Product
Lipopolysaccharides
Clinical trial
Randomized, Placebo-controlled Clinical Trial to Study the Efficacy and Safety of Inhaled Corticosteroid Plus Montelukast Compared With Inhaled Corticosteroid Therapy Alone in Patients With Chronic Asthma
Status: Completed, Estimated PCD: 2009-02-01
Clinical trial
Evaluation of Mechanism(s)Limiting Expiratory Airflow in Chronic, Stable Asthmatics Who Are Non-smokers
Status: Recruiting, Estimated PCD: 2027-06-01
Product
budesonide/formoterol
Product
fluticasone/salmeterol
Product
mometasone/formoterol
Product
Prednisone
Clinical trial
An Open-Label Study to Assess the Safety and Tolerability of Zenhale® (a Fixed-Dose Combination of Mometasone Furoate/Formoterol Fumarate Delivered by Metered Dose Inhaler) in 40 Subjects With Persistent Asthma (Protocol No. 206-00 [P08212])
Status: Completed, Estimated PCD: 2012-09-01
Product
Mometasone Furoate/Formoterol Fumarate (MF/F)
Product
Mometasone Furoate/Formoterol Fumarate (MF/F) 200/5 mcg MDI
Clinical trial
Mechanistic Trial of Dupilumab in Adults With House Dust Mite-associated Asthma Using an Aeroallergen Challenge Chamber
Status: Recruiting, Estimated PCD: 2026-11-01
Clinical trial
Ideal Steroids for Asthma Treatment in the PICU (iSTAT PICU): A Prospective, Comparative, Single-arm Study Assessing Dexamethasone Versus Methylprednisolone in Severe Status Asthmaticus Admitted to the Pediatric Intensive Care Unit
Status: Completed, Estimated PCD: 2021-12-31
Product
Dexamethasone
Clinical trial
A Phase 1, Randomized, 2-part, 7-way Cross-over (Part 1) and 7-way Cross-over (Part 2), Active Device Blinded, Single Dose Study in Mild Asthmatics Aged 18-65 to Assess the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers Containing Propellants HFA-152a (Test) and HFA-134a (Reference) Via Methacholine Bronchoprovocation and Systemic Pharmacodynamic Effects
Status: Not yet recruiting, Estimated PCD: 2024-10-15
Clinical trial
Efficacy of Mepolizumab in Patients With Late-onset Severe Eosinophilic Asthma and Fixed Obstruction
Status: Active (not recruiting), Estimated PCD: 2023-03-15
Clinical trial
Interaction Between Benralizumab and Basophils in Eosinophilic Asthma. Discovering a New Role of an Old Asthma Player: BASEAS STUDY (Basophils in Eosinophilic Asthma)
Status: Completed, Estimated PCD: 2023-10-01
Product
BENRALIZUMAB
Clinical trial
An Open-Label, Single-Arm Study in Moderate Asthma Participants Comparing the Treatment With Long-Acting Beta Agonist Between At-Home Mobile Spirometry and In-Clinic Spirometry (LEARN)
Status: Completed, Estimated PCD: 2023-11-29
Product
Long-Acting Beta Agonist
Clinical trial
Documentation of Efficacy for Intralymphatic Allergen Immunotherapy in a Phase III Randomized, Parallel Group, Double Blind Placebo-controlled Multisite Field Trial
Status: Active (not recruiting), Estimated PCD: 2024-12-31
Product
Polvac Grass+Rye
Product
Saline
Clinical trial
The Role of the Lung Microbiome in Asthma and Its Influence on Treatment Response.
Status: Not yet recruiting, Estimated PCD: 2025-07-01
Product
Biologic Agent
Clinical trial
Adding Biological Therapy to Asthmatic Patients on Allergen Immunotherapy to House Dust Mites
Status: Not yet recruiting, Estimated PCD: 2026-10-01
Clinical trial
Long-term Comparative Effectiveness for Osteoporosis/Osteoporosis and Metabolic Disease in Adult Asthmatic Patients Maintaining Inhaled/Systemic Corticosteroid: a Real-world Evidence
Status: Recruiting, Estimated PCD: 2024-12-30
Product
Corticosteroid
Clinical trial
Dupilumab Efficacy on Bronchial Inflammation, Small Airways Disfunction and Mucous Secretion in the Real Life Severe Asthma Patients
Status: Recruiting, Estimated PCD: 2024-10-01
Clinical trial
Efficacy of Reslizumab Dose Escalation in Patients With Severe Asthma and Persistent Sputum Eosinophilia Despite Standard Dose Therapy
Status: Completed, Estimated PCD: 2024-01-09
Product
Reslizumab
Clinical trial
A Retrospective Chart Review to Investigate Clinical Remission in Patients With Severe Asthma Treated With Biologics in the United Kingdom National Health Service
Status: Recruiting, Estimated PCD: 2024-09-27
Product
Biologic treatment
Clinical trial
Evaluation of Mechanism(s)Limiting Expiratory Airflow in Chronic, Stable Asthmatics Who Are Non-smokers
Status: Recruiting, Estimated PCD: 2027-06-01
Product
Fluticasone + Salmeterol
Product
Budesonide/Formoterol + Fluticasone/Salmeterol
Clinical trial
Utilizing Advances in Digital Inhaler Technology to Understand Heterogeneous Treatment Responses to Biologics in Severe Asthma
Status: Active (not recruiting), Estimated PCD: 2024-09-01
Product
AirDuo
Product
ProAir
Clinical trial
A 26-Week Placebo-Controlled Efficacy and Safety Study of Mometasone Furoate/Formoterol Fumarate Combination Formulation Compared With Mometasone Furoate and Formoterol Monotherapy in Subjects With Persistent Asthma Previously Treated With Medium-Dose Inhaled Glucocorticosteroids
Status: Completed, Estimated PCD: 2008-09-01
Product
Mometasone Furoate + Formoterol Fumarate
Product
Mometasone furoate MDI
Product
Formoterol Fumarate
Product
Metformin extended-release
Clinical trial
Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol in Individuals With Cough Variant Asthma and Chronic Cough
Status: Recruiting, Estimated PCD: 2024-06-30
Product
Mannitol Inhalation
Clinical trial
The Efficacy and Mechanisms of Action of n-3 Poly-unsaturated Fatty Acid Supplementation in People With Non-steroidal Exacerbated Airways Disease and Uncontrolled Asthma
Status: Recruiting, Estimated PCD: 2024-08-31
Clinical trial
How Much Severe is the Severe Asthma of Patients Who Will be Medicated With Mepolizumab? Μeasurement of Respiratory Mechanics by Means of Impulse Oscillometry in Severe Eosinophilic Asthmatics Before and After Mepolizumab Initiation
Status: Completed, Estimated PCD: 2023-10-23
Clinical trial
Nation-wide Health Resource Consumption and Costs Associated With Mepolizumab (Nucala): a French SNDS Database Study
Status: Completed, Estimated PCD: 2023-07-31
Clinical trial
Data Analysis for Drug Repurposing for Effective Alzheimer's Medicines (DREAM) - Montelukast vs Fluticasone
Status: Active (not recruiting), Estimated PCD: 2023-07-07
Product
Fluticasone
Clinical trial
A 12-Week Efficacy and Safety Study of Two Doses of Mometasone Furoate/Formoterol Combination Formulation Compared With Mometasone Furoate Monotherapy, in Persistent Asthmatics Previously Treated With High-Dose Inhaled Glucocorticosteroids
Status: Completed, Estimated PCD: 2008-01-01
Product
Mometasone furoate + Formoterol
Clinical trial
The Effects of Positive Airway Pressure on the Mucolytic Effects of NAC
Status: Recruiting, Estimated PCD: 2027-11-21
Product
N-Acetylcysteine + Albuterol
Clinical trial
Comparison of Microglial Activation in Severe Asthma and Healthy Controls
Status: Recruiting, Estimated PCD: 2028-08-01
Product
PET/MRI using [18F]FEPPA tracer
Clinical trial
Azithromycin Treatment of Hospitalized Children With Asthmatic Symptoms: A Double-blinded, Randomized, Controlled Study
Status: Recruiting, Estimated PCD: 2025-11-13
Clinical trial
Vocal Cord Responses During Hyperventilation in Normal Individuals and in Mild and Severe
Status: Recruiting, Estimated PCD: 2024-12-01
Product
Anticholinergic Medication
Clinical trial
Defining and Treating a New Pediatric Asthma Endotype: Depression-related Asthma Mediated by the Cholinergic Pathway
Status: Completed, Estimated PCD: 2019-03-11
Clinical trial
Early Detection of the Effectiveness of Treatment With Biologicals in Patients With Severe Asthma Using Fluctuation Analysis of Biomarkers
Status: Not yet recruiting, Estimated PCD: 2024-09-30
Product
Biological Drug
Clinical trial
A Two-arm, Placebo-controlled, Randomized Clinical Trial to Evaluate the Effect of Tezepelumab on Airway Structure and Function in Patients With Uncontrolled Moderate-to-severe Asthma
Status: Recruiting, Estimated PCD: 2024-09-01
Drug
Varlilumab
Clinical trial
Phosphodiesterase 4 Inhibitor, Roflumilast, Improves Beta Agonist Responsiveness Compared to Placebo in Low T2 Asthma Patients.
Status: Terminated, Estimated PCD: 2022-12-11
Product
Roflumilast
Clinical trial
Novel Insight in pathologiCal and clinicAl Attributes in Response to mepoLizumab Treatment in Patients With Chronic rhInosinusitis With Nasal pOlyPs With or Without bronchIal Asthma on a Long-term Basis (CALIOPI STUDY)
Status: Recruiting, Estimated PCD: 2026-03-01
Clinical trial
The Use of Benralizumab, an Interleukin-5 Receptor-α Monoclonal Antibody as Treatment of Acute Exacerbations of Airways Disease
Status: Active (not recruiting), Estimated PCD: 2024-02-19
Drug
R-CHOP
Clinical trial
Dose Escalation Clinical Trial of High-dose Oral Montelukast to Inform Future RCT in Children With Acute Asthma Exacerbations
Status: Recruiting, Estimated PCD: 2025-06-30
Clinical trial
A Phase 1 Study to Evaluate Safety, Toxicity, and Potential Mechanisms of Interferon Gamma-primed Mesenchymal Stromal Cells (MSCs) for Moderate-to-severe Persistent Asthma
Status: Recruiting, Estimated PCD: 2025-07-01
Product
Interferon gamma-primed mesenchymal stromal cells
Clinical trial
Exposure to Vaginal Microbiome in C-section Infants at High-risk for Allergies - A Pilot Study
Status: Recruiting, Estimated PCD: 2025-01-01
Product
C-section
Clinical trial
An Open-Label, Multi-Center, Patient Handling Study of Mometasone Furoate/Formoterol Fumarate MDI With an Integrated Dose Counter in Adolescent and Adult Subjects and Adult With Asthma or COPD
Status: Completed, Estimated PCD: 2008-11-01
Product
Mometasone Furoate/Formoterol Furoate
Clinical trial
A Comparison of Mometasone Furoate DPI Versus Budesonide DPI in Mild Persistent and Moderate Persistent Asthmatic Patients
Status: Completed, Estimated PCD: 2009-07-01
Clinical trial
Evaluation of Triple Therapy Using Magnetic Resonance Imaging in Asthma
Status: Active (not recruiting), Estimated PCD: 2023-08-25
Clinical trial
Lignosus Rhinoceros TM02® as a Complementary Therapy for Uncontrolled Asthma: A Prospective, Open-label, Single-arm, Phase II Study
Status: Completed, Estimated PCD: 2023-02-28
Product
Lignosus rhinoceros
Clinical trial
Korean Study of "Real-World" Montelukast Use in Mild Asthmatic Children With Concomitant Allergic Rhinitis
Status: Completed, Estimated PCD: 2007-10-01
Product
Inhaled Corticosteroid
Clinical trial
Glucagon-Like Peptide-1 Receptor Agonist Treatment in Adult, Obesity-related, Symptomatic Asthma (GATA-3)
Status: Recruiting, Estimated PCD: 2025-11-01
Product
Semaglutide
Clinical trial
Use of Omalizumab Will Increase the Pregnancy Rate, Proof of Concept Study, Where Women With Asthma and Infertility Will be Treated Three Times With Weight and IgE Balanced Dosis at the First Day of Their Period Bleeding
Status: Active (not recruiting), Estimated PCD: 2023-12-31
Drug
placebo
Clinical trial
The Improvement of Cough Outcomes After Tezepelumab Treatment in Korean Severe Asthma Patients With Airway Hyperresponsiveness
Status: Not yet recruiting, Estimated PCD: 2025-05-12
Clinical trial
The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus in Pediatric Emergency Medicine Patients: A Pilot Study
Status: Withdrawn, Estimated PCD: 2021-12-01
Drug
Ketamine
Clinical trial
Genetic Association With Various Severities, Phenotypes and Endotypes of Asthma.
Status: Not yet recruiting, Estimated PCD: 2028-01-04
Product
No intervention
Clinical trial
Evaluate the Therapeutic Effect of Inhaled Corticosteroid in Asthmatic Children
Status: Recruiting, Estimated PCD: 2025-12-31
Product
Budesonide/Cisclesonide
Clinical trial
A Study of the Therapeutic Equivalency of MF DPI 100 mcg and 200 mcg Inhalers in Corticosteroid-Dependent Subjects With Moderate Asthma
Status: Completed, Estimated PCD: 2009-03-01
Clinical trial
Therapeutic Control of Aspirin-Exacerbated Respiratory Disease
Status: Completed, Estimated PCD: 2022-03-30
Clinical trial
Beyond the Eosinophil: Understanding the Impact of Eosinophil Depletion on T2 Inflammation. (BEUTI)
Status: Recruiting, Estimated PCD: 2025-01-01
Clinical trial
PrecISE (Precision Interventions for Severe and/or Exacerbation-Prone Asthma) Network Study
Status: Recruiting, Estimated PCD: 2024-12-01
Product
MCT
Product
Clazakizumab
Product
Broncho-Vaxom
Product
Imatinib
Product
Cavosonstat
Clinical trial
Clinical Study on Treatment of Chronic Persistent Bronchial Asthma With Integrated Traditional Chinese and Western Medicine
Status: Recruiting, Estimated PCD: 2024-09-01
Product
Ke Chuan Liu Wei
Product
Yang He Ping Chuan
Clinical trial
Study to Improve dEployment Related Asthma by Using L-citrulline Supplementation (SEALS)
Status: Recruiting, Estimated PCD: 2028-10-01
Product
L-citrulline
Clinical trial
Single Dose Dexamethasone is as Effective as Two Doses in Mild to Moderate Pediatric Asthma Exacerbations in the Emergency Department
Status: Completed, Estimated PCD: 2018-03-01
Product
Dexamethasone Sodium Phosphate
Clinical trial
REVErsing Airway Remodelling With Tezepelumab : a Protocol for a Double-blind Randomized Controlled Trial for Patients With Asthma
Status: Recruiting, Estimated PCD: 2025-12-01
Clinical trial
Effectiveness of a Dietary Supplement Based on a Synergistic Combination of Beta-Glucans and Saccharomyces Cerevisiae Yeast Enriched With Zinc and Selenium in Allergic Patients Undergoing Subcutaneous Immunotherapy Study.
Status: Active (not recruiting), Estimated PCD: 2024-12-20
Product
Specific immunotherapy (SIT)
Clinical trial
Cockroach Immunotherapy in Children and Adolescents
Status: Completed, Estimated PCD: 2022-06-02
Product
German Cockroach Allergenic Extract
Product
Placebo for German cockroach allergenic extract
Clinical trial
A Pilot Randomised Controlled Superiority Trial of Fluticasone-Vilanterol Once Daily Dose for the Treatment of Mild Asthma in Adults
Status: Completed, Estimated PCD: 2023-01-18
Product
fluticasone-vilanterol
Product
Standard Preparation
Clinical trial
Examining the Effect of Salbutamol Use in Asthma and/or Exercise Induced Bronchoconstriction Whilst Exercising in Ozone Air Pollution
Status: Recruiting, Estimated PCD: 2023-08-31
Clinical trial
Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents (PANDA) (CAUSE-01)
Status: Recruiting, Estimated PCD: 2025-08-30
Clinical trial
Replication of the P04334 Asthma Trial in Healthcare Claims Data
Status: Completed, Estimated PCD: 2021-06-11
Product
Formoterol fumarate
Product
Mometasone furoate + Formoterol fumarate
Clinical trial
A Phase 1, Randomized, Open-label, Single Dose, 2-treatment Arm (200 μg and 800 μg), 4-way Crossover Study in Healthy Participants Aged 18 to 55 to Compare the Pharmacokinetics of Salbutamol Administered Via Metered Dose Inhalers Containing Propellants HFA-152A (Test) and HFA-134A (Reference)
Status: Not yet recruiting, Estimated PCD: 2024-09-13
Clinical trial
Mechanisms of Benefit of IL4RA Inhibition in Aspirin-Exacerbated Respiratory Disease: MARINER
Status: Recruiting, Estimated PCD: 2026-04-30
Clinical trial
Comparison of Doses of Nebulized Magnesium Sulphate as an Adjuvant Treatment With Salbutamol in Children With Status Asthmaticus
Status: Completed, Estimated PCD: 2022-11-12
Product
Magnesium Sulfate
Product
Ventolin
Clinical trial
Preventive and Personalized Medicine (2021-2023)
Status: Completed, Estimated PCD: 2023-01-20
Product
SNP analysis
Clinical trial
A Phase 2 Multi-centre Randomized Double-blind Placebo-controlled Parallel Group Study to Examine the Effects of 24 Weeks Tezepelumab 210 mg sc q4wks on Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma
Status: Not yet recruiting, Estimated PCD: 2024-12-30
Clinical trial
Study on Dose-response to Bronchodilator Then Bronchodilator Dose-finding Using the Flow Interruption Technique in Children Aged 2.5 TO 6 Years
Status: Completed, Estimated PCD: 2014-01-01
Product
salbutamol
Clinical trial
The RECONSTRUCT Study - Reconstructing Disease Mechanisms in Asthma
Status: Completed, Estimated PCD: 2019-02-28
Clinical trial
MitoQ for the Treatment of Metabolic Dysfunction in Asthma
Status: Recruiting, Estimated PCD: 2023-12-30
Product
Mitoquinol
Clinical trial
Asthma Inflammation Research
Status: , Estimated PCD: 2025-06-01
Product
Whole lung allergen challenge
Clinical trial
A Phase III, Randomized, Active-Controlled, Parallel-Group Clinical Trial to Study the Efficacy and Long-Term Safety of Mometasone Furoate/Formoterol Fumarate (MF/F, MK-0887A [SCH418131]), Compared With Mometasone Furoate (MF, MK-0887 [SCH032088]), in Children With Persistent Asthma
Status: Completed, Estimated PCD: 2017-12-04
Product
MF MDI 100 mcg BID
Product
MF/F MDI 100/10 mcg BID
Product
MF MDI 100 mcg
Product
Albuterol + Salbutamol
Product
Prednisone/Prednisolone
Clinical trial
A Mechanistic Pilot Open-label Study to Evaluate the Effect of Benralizumab on Airway Function and Inflammation in Patients With Severe, Poorly-controlled Eosinophilic Asthma Using Inhaled Hyperpolarized 129-Xenon MRI
Status: Active (not recruiting), Estimated PCD: 2022-03-20
Product
Xenon
Clinical trial
Supplementing L-citrulline to Overweight Late Asthma oNset Phenotypes to Increase Airway L-arginine/ADMA Ratio and Improve Asthma Control
Status: Recruiting, Estimated PCD: 2024-06-30
Clinical trial
The Nationwide Real-world Status of Oral Corticosteroid Use in Patients With Asthma
Status: Not yet recruiting, Estimated PCD: 2023-12-01
Product
Oral corticosteroids
Clinical trial
Use of Pathological Phenotype to Determine Optimal Management for Moderate to Severe Preschool Wheeze
Status: Completed, Estimated PCD: 2018-08-17
Product
Beclometasone
Product
Co-amoxiclav
Clinical trial
Replication of the D58 Asthma Trial in Healthcare Claims Data
Status: Completed, Estimated PCD: 2021-06-11
Product
Budesonide-Formoterol
Clinical trial
The Benralizumab Pregnancy Exposure Study: A VAMPSS Post Marketing Surveillance Study
Status: Terminated, Estimated PCD: 2023-12-29
Product
Benralizumab-exposure
Product
Exposure to other asthma medications
Clinical trial
A Phase III, Multicentre, Randomized, Double-blind, Single-Dose, 2-Arm, 2-Period, Crossover Study to Investigate the Efficacy of PT027 Compared With Placebo on Exercise-Induced Bronchoconstriction in Adult Patients With Asthma (BREATH)
Status: Recruiting, Estimated PCD: 2024-07-23
Product
Budesonide/Albuterol
Clinical trial
A Randomized, Evaluator-Blind, Crossover, Single Dose Study of the Bronchodilator Effect of Formoterol Fumarate in Combination With Mometasone Furoate Metered Dose Inhaler Delivered With and Without a Spacer Versus Placebo and Foradil® Aerolizer® in Children With Persistent Asthma (Protocol No. P06476)
Status: Completed, Estimated PCD: 2011-10-01
Product
Mometasone Furoate/Formoterol Fumarate MDI
Product
Placebo MDI
Clinical trial
A 26-Week Placebo-Controlled Efficacy and Safety Study of Mometasone Furoate/Formoterol Fumarate Combination Formulation Compared With Mometasone Furoate and Formoterol Monotherapy in Subjects With Persistent Asthma Previously Treated With Low-Dose Inhaled Glucocorticosteroids
Status: Completed, Estimated PCD: 2008-08-01
Product
Mometasone Furoate/Formoterol Fumarate
Clinical trial
Patient Characteristics, Treatment Patterns and Outcomes of Patients Enrolled in the Tezepelumab Patient Access Programme; a Retrospective, Observational Medical Chart Review Conducted in UK Severe Asthma Centres
Status: Recruiting, Estimated PCD: 2024-09-23
Clinical trial
Taiwan Severe Asthma Biologic Registry
Status: Recruiting, Estimated PCD: 2043-02-28
Product
Fish oil
Clinical trial
Innovative Steroid Treatment to Reduce Asthma Development in Children After First-time Rhinovirus Induced Wheezing - the INSTAR Study
Status: Recruiting, Estimated PCD: 2026-05-01
Product
Placebo treatment
Clinical trial
Comparison of Biologicals in Treatment of Severe Asthma - Real Life Experiences
Status: Completed, Estimated PCD: 2020-10-31
Clinical trial
A Phase 2, Double-Blind, Randomized, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study of Povorcitinib in Participants With Inadequately Controlled Moderate to Severe Asthma
Status: Recruiting, Estimated PCD: 2024-12-20
Product
povorcitinib
Product
ICS-LABA
Clinical trial
A Randomized, Placebo-controlled, Parallel Group Study Designed to Assess the Change in Mucociliary Clearance After 12 Weeks of Treatment With Dupilumab in Patients With Moderate to Severe Asthma
Status: Recruiting, Estimated PCD: 2025-04-01
Clinical trial
A Multicenter, Randomized, Double-Blind Study Comparing the Clinical Effects of Intravenous Montelukast With Placebo in Pediatric Patients (Ages 6 to 14 Years) With Acute Asthma
Status: Completed, Estimated PCD: 2008-03-01
Clinical trial
Controlling and Preventing Asthma Progression and Severity in Kids
Status: Active (not recruiting), Estimated PCD: 2028-01-31
Clinical trial
ANCHOR - Assessment of Combination Short-Acting BroNchodilator and Inhaled Corticosteroid Rescue Therapy on Health Outcomes in Routine Care
Status: Recruiting, Estimated PCD: 2026-04-29
Product
Albuterol + Budesonide
Clinical trial
Genotype-tailored Treatment of Symptomatic Acid-Reflux in Children With Uncontrolled Asthma
Status: Completed, Estimated PCD: 2024-01-18
Product
Lansoprazole
Clinical trial
A Cross-sectional Study to Measure Cough in Severe Asthma
Status: Completed, Estimated PCD: 2019-12-30
Product
Citric acid
Clinical trial
Anti Inflammatory Lipid Mediators in Asthma: A Double Blind Placebo Control Cross Over, Proof of Concept Study of CXA-10 to Reduce Bronchial Hyperresponsiveness in Obese Asthmatics; Lipid Anti-Inflammatory Mediators in Asthma to Reduce Hyperresponsiveness in Obese Asthmatics
Status: Recruiting, Estimated PCD: 2029-11-30
Product
CXA-10
Clinical trial
A 52-Week Efficacy and Safety Non-Inferiority Study of Fluticasone Propionate/Salmeterol 250/50mcg BID Delivered by Dry Powder Inhaler (Diskus) Versus Mometasone Furoate/Formoterol Fumarate 200/10mcg BID Delivered by Pressurized Metered-Dose Inhaler in Persistent Asthmatics Previously Treated With Medium Doses of Inhaled Glucocorticosteroids
Status: Completed, Estimated PCD: 2008-11-01
Product
Mometasone furoate/formoterol
Product
Fluticasone propionate/salmeterol (F/SC)
Clinical trial
Viral Infection in Asthma (VIA) Study
Status: Recruiting, Estimated PCD: 2025-05-31
Product
Matching Placebo
Clinical trial
A 12 Week Multicenter, Open-label, Observational Study to Evaluate the Effectiveness of Montelukast Sodium (Singulair®), 4 or 5 mg/Day in Pediatric Subjects With Uncontrolled Asthma
Status: Completed, Estimated PCD: 2008-10-01
Clinical trial
Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma
Status: Recruiting, Estimated PCD: 2025-01-01
Product
Hyperpolarized 129XeMRI
Clinical trial
Methods to Identify and Treat Severe Asthma Patients Project 2: Airway pH Phenotyping
Status: Recruiting, Estimated PCD: 2027-06-30
Product
Glycine Buffer
Clinical trial
Effect of Mepolizumab on the Phenotype/Proteome/Transcriptome of Eosinophils in Severe Eosinophilic Asthma
Status: Recruiting, Estimated PCD: 2023-12-31
Clinical trial
Computed Tomography Air-trapping Characterisation for the Early Identification of Benralizumab Responders Among Eosinophilic Asthma Patients
Status: Completed, Estimated PCD: 2023-06-09
Clinical trial
BenRalizumab Effect on Airway Remodeling in Severe Eosinophilic asTHmatics
Status: Recruiting, Estimated PCD: 2025-12-31
Clinical trial
Evaluation of the Sensitivity of Pharmacokinetics to Differences in the Aerodynamic Particle Size Distribution of Three Different Formulations of Fluticasone Propionate Dry Powder Inhalers
Status: Completed, Estimated PCD: 2018-01-20
Product
Fluticasone Propionate
Clinical trial
A Prospective, Blinded, Cross-Over Trial of the Exposure-Response Relationship of Terbutaline Sulfate in Adults With Asthma
Status: Recruiting, Estimated PCD: 2025-12-01
Product
Terbutaline
Clinical trial
Symptoms Control and adhErenCe Assessment During Treatment With MepolizUmab New pREfilled Devices
Status: Recruiting, Estimated PCD: 2026-03-01
Clinical trial
Antibiotic Treatment of Recurrent Episode of Asthma in Children - a Randomised, Case-controlled Study Within the COPSAC2010 Cohort (Asthma Begins in Childhood)
Status: Active (not recruiting), Estimated PCD: 2024-07-01
Clinical trial
Intravenous Magnesium: Prompt Use for Asthma in Children Treated in the Emergency Department
Status: Completed, Estimated PCD: 2023-05-31
Clinical trial
A Phase II Randomized, Double Blinded, Placebo-controlled Study of Gamma Tocopherol-enriched Supplement on Lower Airway Responses to Inhaled Wood Smoke in Healthy Adults
Status: Completed, Estimated PCD: 2023-03-02
Product
Gamma Tocopherol
Clinical trial
Phase Ib/II Clinical Trial of Safety, Pharmacokinetics and Preliminary Efficacy of MG-K10 Humanized Monoclonal Antibody Injection in Adult Asthmatic Subjects
Status: Recruiting, Estimated PCD: 2023-12-20
Product
MG-K10
Clinical trial
Effects of IL-4R-alpha Inhibition (Dupixent) Inhibition On The Respiratory Microbiome And Immunologic Correlates In Patients With Severe Asthma
Status: Completed, Estimated PCD: 2023-06-29
Clinical trial
An Open Label, Single Dose, 3-Period, Crossover Study to Determine the Pharmacokinetic Profile and Safety of Fluticasone Propionate/Albuterol Sulfate (Fp/ABS) Multidose Dry Powder Inhaler With e-Module (eMDPI) Compared to Fluticasone Propionate Multidose Dry Powder Inhaler (Fp MDPI) in Participants With Asthma (4 to 11 Years Old)
Status: Recruiting, Estimated PCD: 2024-11-06
Product
Fp MDPI
Clinical trial
A Randomized, Double-blind, Placebo-controlled, Parallel-group Study to Evaluate the Effect of Dupilumab on Exercise Capacity in Patients With Moderate-to-Severe Asthma
Status: Completed, Estimated PCD: 2023-07-15
Product
Matching placebo
Clinical trial
Nasal Immune Challenge Study
Status: Recruiting, Estimated PCD: 2024-09-30
Product
R848
Clinical trial
Impact of Omalizumab Withdrawal After a 3 Year Duration Treatment in Well Controlled Severe Allergic Asthma : a Multicentric Randomized Controlled Trial
Status: Recruiting, Estimated PCD: 2025-05-20
Product
OMA
Clinical trial
A 1-Year Safety Study of Medium and High Doses of Mometasone Furoate/Formoterol Combination Formulation and Medium and High Doses of Fluticasone/Salmeterol in Persistent Asthmatics Previously Treated With Medium to High Doses of Inhaled Glucocorticosteroids
Status: Completed, Estimated PCD: 2007-11-01
Product
Mometasone Furoate Combination MDI 200/10 mcg
Product
Mometasone Furoate Combination MDI 400/10 BID
Product
Fluticasone/Salmeterol
Clinical trial
Comparative Study of the Effect of Two Doses of Mometasone Furoate Dry Powder Inhaler 200 mcg and 400 mcg QD PM, Fluticasone Propionate 250 mcg BID, and Montelukast 10 mg QD PM, on Bone Mineral Density in Adults With Asthma
Status: Completed, Estimated PCD: 2009-10-01
Product
montelukast
Clinical trial
A Phase I Clinical Trial to Evaluate the Safety, Tolerability, and Pharmacokinetic Profile of TQC2938 Injection in Healthy Adult Subjects After Single and Multiple Administration
Status: Active (not recruiting), Estimated PCD: 2024-11-01
Product
TQC2938
Clinical trial
Epigenetic Mechanism Reprogramming Mucosal Anti-viral Immunity in Allergic Asthma VIRAL MUCOSAL REPROGRAMMING
Status: Recruiting, Estimated PCD: 2027-05-01
Product
RG-RV
Clinical trial
Effect of IL-4RαR576 Polymorphism on Response to Dupilumab in Asthma, a Genotype-stratified, Randomized, Placebo- Controlled Trial
Status: Recruiting, Estimated PCD: 2026-09-01
Clinical trial
Treatment of Rhinosinusitis With Nasal Polyposis With Dupilumab and Mepolizumab: A Randomized, Multi-centre, Head-to-head Comparison in Real-world Danish Patients
Status: Recruiting, Estimated PCD: 2025-10-30
Product
mepolizumab
Clinical trial
A Randomised, Double Blind, Placebo-controlled, Parallel Group Pilot Study to Determine the Effect of REMICADE on Safety, Efficacy and Biomarkers of Inflammation in Patients With Asthma Receiving Inhaled Corticosteroids
Status: Completed
Product
Study drug
Clinical trial
Microglia Activation in Asthma
Status: Recruiting, Estimated PCD: 2028-12-01
Product
Whole lung antigen challenge
Clinical trial
Increase in Inhaled Corticosteroid Dose vs Triple Therapy in T2-high Asthma Patients Who Remain Uncontrolled With Medium Dose Inhaled Corticosteroids/Long-acting β2 Adrenergic Combination: a Real-life Study. TRICORDA Study
Status: Recruiting, Estimated PCD: 2024-09-30
Product
To compare in both treatment arms the percentage of patients controlled at week 52.
Clinical trial
A Multicenter, Randomized, Double-Blind, Double-Dummy, Parallel-Group Study Evaluating the Effects of 2 Different Regimens of Montelukast (Daily Dosing and Intermittent, Episode-Driven Dosing) Compared With Placebo in the Treatment of Episodic Asthma in Children Aged 6 Months to 5 Years
Status: Completed, Estimated PCD: 2009-08-01
Clinical trial
A Multicentre, Randomised, Double-blind, Parallel Group, Placebocontrolled, Phase 3 Efficacy and Safety Study of Benralizumab (MEDI-563) Added to Medium to High-dose Inhaled Corticosteroid Plus Long-acting β2 Agonist in Patients With Uncontrolled Asthma.
Status: Completed, Estimated PCD: 2023-01-30
Clinical trial
Asthma Exacerbation Profile in Patients on Open Label Treatment With Benralizumab for Severe Eosinophilic Asthma - an Exploratory Cohort Study
Status: Completed, Estimated PCD: 2024-02-22
Clinical trial
Effect of Incentive Spirometery on Asthmatic Pregnant Women
Status: Completed, Estimated PCD: 2021-09-15
Product
Pulmicort
Clinical trial
Effect of Clopidogrel on Allergen Challenge in Asthma
Status: Completed, Estimated PCD: 2014-05-01
Product
Clopidogrel
Clinical trial
Targeted AntiBiotics for Chronic Pulmonary Disease: Can Targeted Antibiotic Therapy Improve the Prognosis of Pseudomonas Aeruginosa Infected Patients With Chronic Pulmonary Obstructive Disease, Non-cystic Fibrosis Bronchiectasis and Asthma? A Multicenter, Randomized, Controlled, Open-label Trial.
Status: Terminated, Estimated PCD: 2023-03-01
Product
Piperacillin/tazobactam
Product
Ciprofloxacin
Clinical trial
Escitalopram in Asthma Patients With Frequent Exacerbation
Status: Not yet recruiting, Estimated PCD: 2028-12-01
Product
Escitalopram
Clinical trial
Arg/Arg Genotype and Long Acting Beta Agonists in Asthma. Improved Quality of Care for Patients With Asthma.
Status: Completed, Estimated PCD: 2010-11-01
Product
Fluticasone with Salmeterol
Product
Ipratropium
Clinical trial
Analysis of Sexual Bias in Type 2 Innate Lymphoid Cells (ILC2) in Asthmatic Patients: Role of Androgens
Status: Completed, Estimated PCD: 2022-05-01
Product
Blood sample collection
Clinical trial
THE PEBBLES STUDY: A Randomised Controlled Trial to Prevent Eczema, Food Allergy and Sensitisation Using a Skin Barrier Improvement Strategy
Status: Active (not recruiting), Estimated PCD: 2027-05-31
Product
EpiCeram
Clinical trial
Symptom-driven Combination Inhaled Corticosteroids and Long-acting Beta Agonist Therapy for Patients With Asthma Who Are Identified as Non-adherent to Daily Maintenance Inhalers
Status: Recruiting, Estimated PCD: 2023-11-30
Clinical trial
Daily Vitamin D for Sickle-cell Respiratory Complications
Status: Active (not recruiting), Estimated PCD: 2024-06-30
Product
Vitamin D3
Clinical trial
Assessment of Children and Adolescents With Asthma: An Observational Prospective Study
Status: Active (not recruiting), Estimated PCD: 2025-10-31
Product
Fixed-Dose Combination of Inhaled Corticosteroids and Long- Acting Beta-agonist
Clinical trial
Assessment of Bronchial Asthma Among Patients Attending Sohag University Hospital
Status: Recruiting, Estimated PCD: 2024-12-30
Drug
corticosteroids
Clinical trial
Expertise Asthma COPD Program With Digital Support
Status: Recruiting, Estimated PCD: 2025-01-31
Clinical trial
Salbutamol Reversal of Methacholine Induced Bronchoconstriction: Vibrating Mesh Nebulizer Versus Pressurized Metered Dose Inhaler
Status: Recruiting, Estimated PCD: 2024-09-30
Clinical trial
FUNLUM: Functional Lung MRI for Early Treatment Response Assessment and Outcome Prediction for Patients With Severe Eosinophilic Asthma on Anti IL 5 Antibody Therapy
Status: Recruiting, Estimated PCD: 2025-02-01
Clinical trial
Ginger's Therapeutic Potential in Asthma
Status: Completed, Estimated PCD: 2021-02-28
Product
Ginger Extract
Product
Other treatments
Product
Inhaler
Clinical trial
A Single and Multiple-dose Escalation First-in-Human Study Evaluating the Safety, Tolerability, Immunogenicity, and Pharmacokinetics of LQ036 Administered Via Inhalation and IV Infusion in Healthy Subjects and Patients With Mild Asthma.
Status: Terminated, Estimated PCD: 2023-03-02
Product
LQ036
Clinical trial
Mepolizumab for the Treatment of Chronic Cough With Eosinophilic Airways Diseases
Status: Recruiting, Estimated PCD: 2023-12-31
Clinical trial
Safety of VSL#3 for Adult Asthmatics
Status: Terminated, Estimated PCD: 2013-01-01
Product
VSL#3
Clinical trial
Anti-Inflammatory Reliever Therapy for Asthma Using Inhaled Budesonide/Formoterol As-needed With or Without Maintenance in South African Children: A Pragmatic Open Label Phase 3 Randomised Controlled Trial
Status: Not yet recruiting, Estimated PCD: 2025-05-28
Product
Budesonide/formoterol
Drug
standard of care
Clinical trial
The Effect of NAC on Lung Function and CT Mucus Score
Status: Recruiting, Estimated PCD: 2024-03-01
Product
0.9% Saline + Albuterol
Clinical trial
Improving Inhaler Treatment and Small Airways Assessment in Chronic Obstructive Pulmonary Disease (COPD)
Status: Completed, Estimated PCD: 2017-11-27
Product
SALBUTAMOL
Clinical trial
An Exploratory Study of Mometasone Furoate Nasal Spray in Patients With Moderate-severe Persistent Allergic Rhinitis and Intermittent Asthma: Effects on the Quality of Life Evaluated With the Rhinasthma Questionnaire
Status: Completed, Estimated PCD: 2009-05-01
Product
Mometasone furoate nasal spray
Product
Placebo nasal spray
Clinical trial
A 52-week, Randomised, Double-blind, Placebo-controlled, Parallel-group, Multi-centre Study of the Efficacy and Safety of GSK3511294 Adjunctive Therapy in Adult and Adolescent Participants With Severe Uncontrolled Asthma With an Eosinophilic Phenotype
Status: Completed, Estimated PCD: 2023-11-21
Clinical trial
Aggravated Airway Inflammation: Research on Biological Treatment (Mepolizumab)
Status: Recruiting, Estimated PCD: 2024-12-31
Product
L-ctirulline
Clinical trial
Phase IIa Trial to Evaluate the Pharmacokinetic/Pharmacodynamic Characteristics and Safety of JYB1904 in Patients With Allergic Asthma
Status: Not yet recruiting, Estimated PCD: 2025-10-31
Product
JYB1904
Clinical trial
Ketamine Efficacy for Acute Severe Bronchospasm in Mechanically Ventilated-critically Ill Patients: a Randomized Controlled Trial
Status: Completed, Estimated PCD: 2017-06-16
Clinical trial
A Multicenter, Double-Blind, Randomized, Crossover Design Study to Evaluate the Effect of Montelukast Vs. Salmeterol on the Inhibition of Exercise-Induced Bronchoconstriction in Asthmatic Patients Aged 6-14 Years
Status: Completed, Estimated PCD: 2008-11-01
Product
Salmeterol
Clinical trial
An 8 Week Study to Evaluate the Effectiveness of Adding Montelukast to Inhaled Corticosteroid (ICS) to the ICS/Long-Acting Beta 2-Agonist Therapy in Adult Subjects With Asthma and Allergic Rhinitis
Status: Completed, Estimated PCD: 2008-01-01
Clinical trial
Comparison of Immune Profiles in Chronic Rhinosinusitis Patients After Mepolizumab Treatment
Status: Recruiting, Estimated PCD: 2024-12-30
Clinical trial
A 12-Week, Randomized, Placebo-Controlled, Dose-Ranging, Efficacy and Safety Study of Mometasone Furoate Metered Dose Inhaler in the Treatment of Children Ages 5 to 11 Years With Persistent Asthma (Phase 2; Protocol No. P04223AM3)
Status: Completed, Estimated PCD: 2015-01-29
Product
Placebo Dry Powder Inhaler
Clinical trial
Randomized, Placebo-controlled, Multicenter Study to Assess the Efficacy, Safety and Tolerability of ORal Bacterial EXtract for the Prevention of Wheezing Lower Respiratory Tract Illness (ORBEX)
Status: Active (not recruiting), Estimated PCD: 2025-12-31
Clinical trial
A Multicenter, Randomized, Double-Blind, Parallel-Group 6-Month Study to Evaluate the Efficacy and Safety of Oral Montelukast Sodium, Fluticasone Propionate and Placebo in Patients With Chronic Asthma Who Smoke Cigarettes
Status: Completed, Estimated PCD: 2010-04-01
Clinical trial
A Randomized, 52-Week Treatment Double-Blind, Placebo-Controlled Efficacy and Safety Study of Dupilumab 300 mg Every Other Week After Endoscopic Sinus Surgery in Patients With Allergic Fungal Rhinosinusitis (AFRS) on a Background Therapy With Intranasal Corticosteroid Spray
Status: Recruiting, Estimated PCD: 2025-12-01
Drug
Dupilumab
Clinical trial
A Randomized, Double-blind, Multicentre, Event-driven, Parallel Group, Phase III Study Evaluating the Efficacy and Safety of PT027 Compared With PT007 Administered As Needed in Symptomatic Chinese Adults With Asthma (BAIYUN)
Status: Not yet recruiting, Estimated PCD: 2026-10-30
Clinical trial
A Multicentre, Randomised, Open-Label, Parallel-Group, Phase IIIb Study to Assess the Potential for Tezepelumab-treated Patients With Severe Asthma to Reduce Background Therapy While Sustaining Asthma Control and Clinical Remission
Status: Not yet recruiting, Estimated PCD: 2027-06-30
Product
Mannitol
Clinical trial
CIVETTA: Correlating Inflammatory Values of FEno, SympToms, SpuTum and Lung Function in Asthma
Status: Active (not recruiting), Estimated PCD: 2025-05-01
Product
Fluticason
Clinical trial
Safety, Tolerability and Pharmacodynamics of Single and Multiple Ascending Doses of OM-85-IN Versus Placebo in Healthy Volunteers, and Patients With Mild Allergic Asthma Using Nasal Allergen Challenge
Status: Recruiting, Estimated PCD: 2025-02-28
Product
OM-85-IN
Clinical trial
A Multicenter, Randomized, Double-blind, Parallel-group, Placebo-controlled Phase III Clinical Study Evaluating the Efficacy and Safety of SIM0718 in Adults and Adolescents With Asthma
Status: Not yet recruiting, Estimated PCD: 2027-06-30
Product
SIM0718
Clinical trial
Lung Immune Challenge Study Controlled Exposure to Inhaled Resiquimod (R848) to Study Mechanisms of Inflammation
Status: Recruiting, Estimated PCD: 2025-05-01
Product
Biological Treatment