Organization
Geron
4 clinical trials
2 abstracts
Clinical trial
A Randomized Open-Label, Phase 3 Study to Evaluate Imetelstat (GRN163L) Versus Best Available Therapy (BAT) in Patients With Intermediate-2 or High-risk Myelofibrosis (MF) Relapsed / Refractory (R/R) to Janus Kinase (JAK) InhibitorStatus: Recruiting, Estimated PCD: 2026-04-27
Clinical trial
A Study to Evaluate Imetelstat (GRN163L) in Transfusion-Dependent Subjects With IPSS Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS) That is Relapsed/Refractory to Erythropoiesis-Stimulating Agent (ESA) TreatmentStatus: Active (not recruiting), Estimated PCD: 2023-10-13
Clinical trial
An Open Label, Phase 1/1b Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics and Clinical Activity of Imetelstat in Combination With Ruxolitinib in Patients With MyelofibrosisStatus: Recruiting, Estimated PCD: 2025-06-06
Abstract
IMerge: Results from a phase 3, randomized, double-blind, placebo-controlled study of imetelstat in patients (pts) with heavily transfusion dependent (TD) non-del(5q) lower-risk myelodysplastic syndromes (LR-MDS) relapsed/refractory (R/R) to erythropoiesis stimulating agents (ESA).Org: Yale School of Medicine and Yale Cancer Center, Yale University, Leipzig University Hospital, Azienda Ospedaliero Universitaria Careggi, University of Florence, Hôpital Saint-Louis, Université de Paris, Sylvester Comprehensive Cancer Center, University of Miami Health System,
Abstract
Efficacy of imetelstat on red blood cell (RBC)-transfusion independence (TI) in the absence of platelet transfusions or myeloid growth factors in IMerge.Org: Yale University, Azienda Ospedaliero Universitaria Careggi, University of Florence, University of Florence, AOUC, Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, University Hospital Leipzig,