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Yale University

251 clinical trials

51 abstracts

Abstract
Evaluating the diagnostic performance of 18F-fluciclovine for detection of recurrent brain metastases after radiation therapy: Results from a prospective phase 2 trial.
Org: Department of Neurosurgery, Prince of Wales Hospital, Department of Radiation Oncology, Baptist Health South Florida, Perelman School of Medicine, Department of Radiology,
Abstract
Phase II trial of pembrolizumab in patients with brain metastases.
Org: Massachusetts General Hospital and Harvard Medical School, Dana-Farber Cancer Institute, Dana-Farber/Brigham and Women's Cancer Center, Massachusetts General Hospital, Yale University,
Clinical trial
The SUGAR Study: (SBRT and Ultrashort GnRH Antagonist-Relugolix) for Clinicogenomic Unfavorable Intermediate Risk Prostate Cancer
Status: Recruiting, Estimated PCD: 2028-02-01
Abstract
Correlation of hormone receptor positive HER2-negative/MammaPrint high-2 breast cancer with triple negative breast cancer: Results from gene expression data from the ISPY2 trial.
Org: Yale Cancer Center, Yale School of Medicine, New Haven, CT, Yale University School of Medicine, Bioinformatics Support Program,
Abstract
Relationship between receipt of combined axillary dissection and nodal irradiation and age.
Org: Brigham and Women's Hospital, Dana-Farber Cancer Institute, Yale University,
Abstract
Oral cancer drug repositories: Challenges and solutions.
Org: Bangalore Medical College And Research Institute, Yale University, Yale School of Medicine, Yale-New Haven Hospital,
Abstract
Characterizing the authorship of phase 3 randomized clinical trials in oncology, 1960-2023.
Org: Brown University/Legorreta Cancer Center, Dana-Farber Cancer Institute, Vanderbilt University Medical Center, Vanderbilt-Ingram Cancer Center, University of Kansas Medical Center,
Abstract
Understanding trends of US breast cancer hospitalization, mortality and costs using the National Inpatient Sample database.
Org: MedStar Georgetown Cancer Institute, Yale University, Harvard T.H. Chan School of Public Health, NYU Langone Health, Dow University of Health Sciences,
Abstract
Integrating 4 Methods (In4M) to evaluate physical function in patients with cancer: Results of a comprehensive digital health study.
Org: Mayo Clinic, U.S. Food and Drug Administration, Yale University, Fight Colorectal Cancer, Arlington, VA, CancerHacker Lab,
Abstract
Real-world use of a CSF circulating tumor cell assay in the diagnosis and management of leptomeningeal metastasis.
Org: Yale University,
Clinical trial
Effects of E-cigarette Flavors on Youth
Status: Completed, Estimated PCD: 2023-06-16
Clinical trial
Assessing a Natural Product Plus Bioadhesive Nanoparticle (BNP) Sunscreen
Status: Completed, Estimated PCD: 2023-09-01
Clinical trial
Understanding Factors That Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine Receptors
Status: Withdrawn, Estimated PCD: 2024-02-01
Clinical trial
The Study of NC318 Alone or in Combination With Pembrolizumab in Patients With Advanced Non-small Cell Lung Cancer
Status: Recruiting, Estimated PCD: 2025-06-30
Clinical trial
Repeat Dosing of Psilocybin in Headache Disorders
Status: Completed, Estimated PCD: 2023-11-05
Clinical trial
The Safety of Thoracentesis, Tunneled Pleural Catheter (Pleurx), and Chest Tubes in Patients Taking Novel Oral Anti-Coagulants (NOAC).
Status: Completed, Estimated PCD: 2020-01-01
Clinical trial
Imaging the Neurochemistry of Drug Addiction With PET
Status: Recruiting, Estimated PCD: 2024-09-01
Clinical trial
Sex Differences in Neural Response to Cannabidiol
Status: Completed, Estimated PCD: 2023-04-27
Clinical trial
Feasibility, Acceptability, and Preliminary Efficacy of Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: An Open-Label Pilot Study
Status: Not yet recruiting, Estimated PCD: 2025-12-31
Clinical trial
The Impact of Pre-operative Olanzapine on Quality of Recovery-40 Scores After Discharge From Ambulatory Surgery
Status: Recruiting, Estimated PCD: 2026-01-01
Clinical trial
A Behavioral Treatment With Sequenced Adjunctive Pharmacotherapy for Weight Regain After Bariatric Surgery: A Pilot Study
Status: Completed, Estimated PCD: 2022-09-13
Clinical trial
Phase II Study of Peri-Operative Modified Folfirinox in Localized Pancreatic Cancer
Status: Active (not recruiting), Estimated PCD: 2026-02-01
Clinical trial
Parametric Cardiac 18F-flutemetamol PET Imaging in ATTR Cardiomyopathy
Status: Recruiting, Estimated PCD: 2025-06-01
Clinical trial
The Use of Guanfacine (GUA) (3mg/Day) to Reduce Drug Craving, Improve Cognitive Flexibility and Result in Associated Lower Drug Use in Women With Substance Use Disorder (SUD).
Status: Completed, Estimated PCD: 2022-11-30
Clinical trial
Exploration of Synaptotrophic Effects of Psilocybin in Opioid Use Disorder (OUD)
Status: Not yet recruiting, Estimated PCD: 2027-01-01
Clinical trial
Mechanisms of Hypertension in Women With Polycystic Ovary Syndrome
Status: Terminated, Estimated PCD: 2022-06-30
Abstract
Correlation of HER2 low status in I-SPY2 with molecular subtype, response, and survival.
Org: University of California Comprehensive Cancer Center, San Francisco, CA, University of California, San Francisco, San Francisco, CA, University of Texas MD Anderson Cancer Center, Houston, TX, UC Davis, Davis, CA, Masonic Cancer Center, Minneapolis, MN,
Abstract
International medical graduates (IMG) representation at international oncology conference meetings.
Org: Roswell Park Comprehensive Cancer Center, Memorial Sloan Kettering Cancer Center, The University of Texas MD Anderson Cancer Center, Gazi University Faculty of Medicine, University of Arkansas for Medical Sciences,
Abstract
Evaluation of the study of control arms in randomized clinical trials of cancer.
Org: Brown University School of Medicine-Rhode Island Hospital, Memorial Sloan Kettering Cancer Center, Yale University School of Medicine, Saint Louis University School of Medicine, UNC Lineberger Comprehensive Cancer Center,
Clinical trial
Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis - A Prospective Clinical Trial
Status: Active (not recruiting), Estimated PCD: 2025-05-31
Clinical trial
Measuring the Neuroimmune Response to Alcohol
Status: Completed, Estimated PCD: 2021-11-20
Clinical trial
Reduction of Demoralization After Treatment of TD With Valbenazine
Status: Not yet recruiting, Estimated PCD: 2024-07-01
Clinical trial
Targeting the Gut-brain Axis to Facilitate Weight Loss in High Fat Diet Consumers
Status: Active (not recruiting), Estimated PCD: 2027-12-31
Clinical trial
Effects of Menthol in E-cigarettes on Smoking Behaviors
Status: Completed, Estimated PCD: 2023-07-25
Clinical trial
Addictive Threshold of Nicotine
Status: Recruiting, Estimated PCD: 2027-01-30
Clinical trial
Does Endotoxin Administration Increase Alcohol Consumption in Individuals With AUD?
Status: Recruiting, Estimated PCD: 2024-10-31
Clinical trial
A Phase II Evaluation of Pembrolizumab, a Humanized Antibody Against PD-1, in the Treatment of Persistent or Recurrent Hypermutated/Ultramutated Endometrial Cancer Identified by Next Generation Sequencing (NGS) and Comprehensive Genomic Profiling (CGP)
Status: Active (not recruiting), Estimated PCD: 2025-10-01
Clinical trial
Behavioral and Pharmacologic Treatment of Binge Eating and Obesity
Status: Completed, Estimated PCD: 2021-12-01
Clinical trial
Ketamine for the Treatment of Depression in Parkinson's Disease (KET-PD)
Status: Recruiting, Estimated PCD: 2024-08-01
Clinical trial
Evaluating the Immune Response to COVID19 Vaccination in Immunodeficient Patients
Status: Active (not recruiting), Estimated PCD: 2024-05-31
Clinical trial
Alpha-Amino-3-Hydroxy-5-Methyl-4- Isoxazole Propionic Acid Receptor Components of the Anti-Depressant Ketamine Response
Status: Recruiting, Estimated PCD: 2032-12-01
Clinical trial
The Role of Neuroactive Steroids in Stress, Drug Craving and Drug Use in Cocaine Use Disorders
Status: Completed, Estimated PCD: 2023-05-08
Clinical trial
Anesthetic Greater Occipital Nerve Blockade in Veterans With Post-Traumatic Headache: Sub-study 1
Status: Recruiting, Estimated PCD: 2025-03-31
Clinical trial
A Phase 2 Trial of Pembrolizumab Plus Bevacizumab in Patients With Metastatic Melanoma or Non-small Cell Lung Cancer With Untreated Brain Metastases
Status: Recruiting, Estimated PCD: 2025-04-01
Clinical trial
A Translational and Neurocomputational Evaluation of a Dopamine Receptor 1 Partial Agonist for Schizophrenia
Status: Active (not recruiting), Estimated PCD: 2024-03-22
Clinical trial
Cannabidiol Pharmacotherapy for Co-occurring Opioid Use Disorder and Chronic Pain
Status: Recruiting, Estimated PCD: 2025-02-28
Clinical trial
Topical Antibacterial Agents for Prevention of COVID-19
Status: Completed, Estimated PCD: 2023-09-22
Clinical trial
Clinical Evaluation of NMDA Modulator NYX-783 for OUD: Randomized, Double-blind, Placebo-Controlled Study to Assess Safety, Tolerability, and Pharmacokinetics of NYX-783 in Combination With Oxycodone (Study 1)
Status: Recruiting, Estimated PCD: 2024-07-31
Clinical trial
Feasibility, Acceptability, and Preliminary Efficacy of Off-Label Medications for Alcohol Use Disorder Among Patients With HIV: An Open-Label Pilot Study
Status: Recruiting, Estimated PCD: 2024-12-31
Clinical trial
A Multicenter Phase 2 Trial to Evaluate Intracranial Response to Pembrolizumab and Lenvatinib in Patients With Brain Metastases From Melanoma or Renal Cell Carcinoma Who Are Anti-PD1/PD-L1 Experienced
Status: Recruiting, Estimated PCD: 2027-01-31
Clinical trial
Fixed Order, Open-Label, Dose-Escalation Study of DMT in Humans
Status: Active (not recruiting), Estimated PCD: 2024-12-01
Clinical trial
Does Propranolol, a Beta Blocker, Attenuate Stress-Induced Drinking?
Status: Recruiting, Estimated PCD: 2025-02-28
Clinical trial
Superficial Cervical Plexus Block and Quality of Recovery After Thyroidectomy: A Randomized Controlled Trial
Status: Recruiting, Estimated PCD: 2024-12-31
Abstract
ERBB2 mutations and association with molecular phenotype in urothelial carcinoma.
Org: Dana-Farber Cancer Institute, Yale University School of Medicine, Yale School of Medicine, Yale Cancer Center, Yale University,
Abstract
Impact of semaglutide and tirzepatide administration on weight in women with stage I-III breast cancer.
Org: Yale University School of Medicine, Yale University, Yale Center for Analytical Sciences, Yale School of Medicine,
Clinical trial
A Randomized Phase II Evaluation of Weekly Ixabepilone With or Without Biweekly Bevacizumab in Recurrent or Persistent Platinum-resistant/Refractory Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers
Status: Completed, Estimated PCD: 2022-12-29
Abstract
Overcoming barriers in equitable care delivery for women with gynecologic cancers: Outcomes and analysis from an educational program on health equity.
Org: Clinical Care Options, LLC, Vanderbilt University Medical Center, The University of Texas MD Anderson Cancer Center, Stem Cell Transplantation Rsch, Houston, TX, University of California Irvine, Yale University,
Abstract
Associations between violence, distress, and cancer in transgender and non-transgender people.
Org: Yale Cancer Center, University of Rochester Medical Center, James P. Wilmot Cancer Center - Pluta, Columbia University - Mailman School of Public Health, Emory University, Atlanta, GA, USA,
Abstract
Efficacy of imetelstat on red blood cell (RBC)-transfusion independence (TI) in the absence of platelet transfusions or myeloid growth factors in IMerge.
Org: Yale University, Azienda Ospedaliero Universitaria Careggi, University of Florence, University of Florence, AOUC, Medical Clinic and Policlinic 1, Hematology and Cellular Therapy, University Hospital Leipzig, University Hospital Leipzig,
Abstract
Real world outcomes of patients with small cell lung cancer (SCLC) presenting with brain metastasis at diagnosis in a single institution health system.
Org: Yale New Haven Hospital, Yale University, Department of Therapeutic Radiology, Yale School of Medicine, Department of Neurosurgery, Peking Union Medical College Hospital, Beijing, China,
Abstract
A medical school curriculum to foster the physician-patient relationship through narrative medicine.
Org: Yale School of Medicine, Yale University,
Clinical trial
The Impact of Phosphate Metabolism on Healthy Aging
Status: , Estimated PCD: 2024-08-01
Abstract
Clinical benefit of luspatercept treatment (tx) in transfusion-dependent (TD), erythropoiesis-stimulating agent (ESA)–naive patients (pts) with very low-, low- or intermediate-risk myelodysplastic syndromes (MDS) in the COMMANDS trial.
Org: Yale School of Medicine, Yale Cancer Center, Yale University, University Hospital Leipzig, Cancer Center IRCCS Humanitas Research Hospital,
Abstract
HLA class-I antigen presentation machinery (APM) alterations mediate immune evasion in lung cancer brain metastases.
Org: Yale University, Catalan Institute of Oncology-Hospitalet, Hospital Duran i Reynals, IDIBELL Medical Oncology,
Clinical trial
SV2A Density Cannabis Use Disorder
Status: Recruiting, Estimated PCD: 2027-05-01
Clinical trial
A Smart Approach to Treating Tobacco Use Disorder in Persons Living With HIV
Status: Active (not recruiting), Estimated PCD: 2024-11-30
Clinical trial
Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Substudy III
Status: Active (not recruiting), Estimated PCD: 2024-12-01
Clinical trial
Systems Investigation of Vaccine Responses in Aging and Frailty
Status: Recruiting, Estimated PCD: 2027-04-01
Clinical trial
A Phase II Evaluation of Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2-SN-38 Antibody-drug Conjugate in Recurrent or Persistent Platinum-resistant Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers
Status: Recruiting, Estimated PCD: 2025-11-01
Clinical trial
Muscarinic M1 Receptor Availability and Cognition in Schizophrenia
Status: Completed, Estimated PCD: 2023-10-31
Clinical trial
Effects of E-Cigarette Flavors on Adults
Status: Completed, Estimated PCD: 2023-07-12
Clinical trial
Project Tara: Pharmacist-led Intervention for Injectable HIV Treatment for Women With Health-related Social Needs
Status: Not yet recruiting, Estimated PCD: 2025-05-30
Clinical trial
Mechanism and Effects of Manipulating Chloride Homeostasis in Acute Heart Failure
Status: Completed, Estimated PCD: 2022-09-07
Clinical trial
Pharmacological and Behavioral Treatments to Treat Loss-of-Control Eating and Improve Weight Outcomes After Bariatric Surgery: Maintenance Treatment (Stage 2a)
Status: , Estimated PCD: 2027-05-01
Clinical trial
Investigating the Role of the Polyol Pathway in the Central Nervous System Production of Fructose: an Intervention Study
Status: Completed, Estimated PCD: 2020-03-20
Clinical trial
The Stimulation To Induce Mothers (STIM) Study: A Parallel Group Randomized Controlled Trial
Status: Recruiting, Estimated PCD: 2028-11-01
Clinical trial
Pilot Study of Non-invasive Measurement of PD-L1 Levels With Positron Emission Tomography (PET) in Head and Neck Malignancies and Intracranial Metastases
Status: Terminated, Estimated PCD: 2024-01-31
Clinical trial
Characterization of Immune Response to Intradermal Influenza Vaccination
Status: Recruiting, Estimated PCD: 2026-05-01
Clinical trial
A Phase II Study of Pembrolizumab for Patients With Head and Neck Squamous Cell Carcinoma With Residual Disease Following Definitive Chemoradiation
Status: Terminated, Estimated PCD: 2020-02-01
Clinical trial
Effect of Allopregnanolone on Stress-induced Craving
Status: Completed, Estimated PCD: 2023-09-01
Clinical trial
An Electrophysiological Examination of CB1 and NMDA Receptors in Humans
Status: Completed, Estimated PCD: 2022-06-21
Clinical trial
Brain Network Changes Accompanying and Predicting Responses to Pharmacotherapy in OCD
Status: Recruiting, Estimated PCD: 2024-07-31
Clinical trial
Mindfulness-Based ADHD Treatment for Children: a Feasibility Study
Status: Recruiting, Estimated PCD: 2024-06-30
Clinical trial
Effect of Cannabis Use on Synaptic Density in Older Adults
Status: Recruiting, Estimated PCD: 2024-09-30
Clinical trial
Safety and Efficacy of Psilocybin for the Treatment of Headache Disorders
Status: Completed, Estimated PCD: 2022-06-30
Clinical trial
Impact of Flavors on Nicotine Perception and Self-Administration Via E-cigarettes
Status: , Estimated PCD: 2024-05-31
Clinical trial
A Phase I/II Trial of Evaluating the Combination of MK-3475 and Stereotactic Body Radiotherapy in Patients With Metastatic Melanoma or NSCLC
Status: Completed, Estimated PCD: 2019-02-19
Clinical trial
A Phase 2 Study of Autologous Tumor Infiltrating Lymphocytes (LN-145) in Patients With Pretreated Metastatic Triple Negative Breast Cancer
Status: Completed, Estimated PCD: 2023-01-30
Clinical trial
Behavioral and Pharmacologic Treatment of Binge Eating and Obesity
Status: Completed, Estimated PCD: 2021-12-16
Clinical trial
Intervention of HIV, Drug Use and the Criminal Justice System in Malaysia
Status: Completed, Estimated PCD: 2014-12-01
Clinical trial
Nicotine Discrimination in Smokers
Status: Completed, Estimated PCD: 2023-07-19
Clinical trial
Safety and Efficacy of Psilocybin for the Treatment of Headache Disorders: Sub-Study I
Status: Completed, Estimated PCD: 2021-04-30
Clinical trial
Phase 2 Study of Pembrolizumab and Brentuximab Vedotin in Subjects With Relapsed/Refractory CD30 Positive T-cell Lymphoma
Status: Recruiting, Estimated PCD: 2028-04-30
Clinical trial
GLP-1 Analogue Effects on Food Cues, Stress, Motivation for Highly Palatable Foods, and Weight
Status: Recruiting, Estimated PCD: 2025-01-01
Clinical trial
A Trial Comparing the Effectiveness and Tolerability of Medications in Older Adults With Stable Angina and Multiple Chronic Conditions: LIVEBETTER
Status: Recruiting, Estimated PCD: 2027-05-30
Clinical trial
Influence of Mavoglurant on Alcohol Craving and Drinking in Heavy Drinkers
Status: Not yet recruiting, Estimated PCD: 2026-05-31
Clinical trial
Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity
Status: Active (not recruiting), Estimated PCD: 2024-07-01
Clinical trial
Addiction, HIV and Tuberculosis in Malaysian Criminal Justice Settings
Status: Active (not recruiting), Estimated PCD: 2024-05-01
Clinical trial
Torsemide Comparison With Furosemide for Management of Patients With Stable Heart Failure
Status: Active (not recruiting), Estimated PCD: 2023-06-30
Clinical trial
Semaglutide, 2.4mg, Once Weekly: Effects on Beta-cell Preservation and Reduction of Intrahepatic Triglyceride Content in Obese Youth With Prediabetes (IGT)/Early Type 2 Diabetes (T2D) and Non-Alcoholic Fatty Liver Disease (NAFLD)
Status: Recruiting, Estimated PCD: 2026-12-01
Clinical trial
Evaluation of the Clinical and Psychological Impact of Vitamin D Replacement in Adolescent Females at Risk for Polycystic Ovarian Syndrome (PCOS)
Status: Not yet recruiting, Estimated PCD: 2025-03-01
Clinical trial
Pharmacological and Behavioral Treatments to Treat Loss-of-Control Eating and Improve Weight Outcomes After Bariatric Surgery: Medication Change for Non-Responders (Stage 2b)
Status: , Estimated PCD: 2027-05-01
Clinical trial
Acute Effects of Vaping Nicotine on Reward Processing and Inhibitory Control in Young Adults
Status: Completed, Estimated PCD: 2022-08-17
Clinical trial
Investigation of the Effects of Cannabis on the Immune-genome in People With HIV
Status: Recruiting, Estimated PCD: 2025-10-01
Clinical trial
A Pilot Study on the Safety and Efficacy of Mavoglurant in Alcohol Drinking
Status: Completed, Estimated PCD: 2023-07-13
Clinical trial
Sodium-Glucose Cotransporter-2 Inhibitor for Acute Cardiorenal Syndrome: A Feasibility Study
Status: Recruiting, Estimated PCD: 2026-05-01
Clinical trial
Utility of Brexanolone to Target Stress-induced Alcohol Use Among Men and Women With Posttraumatic Stress Disorder
Status: Recruiting, Estimated PCD: 2024-04-30
Clinical trial
Cannabinoids, Learning, and Memory
Status: Active (not recruiting), Estimated PCD: 2018-08-10
Clinical trial
Obesity Complicating Type 1 Diabetes in Young Adults: Physiology and Impact of GLP-1 Analogue Anti-obesity Treatment on Cardiometabolic Risk Factors
Status: Not yet recruiting, Estimated PCD: 2025-06-01
Clinical trial
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
Status: Recruiting, Estimated PCD: 2024-08-01
Clinical trial
JAK1 Inhibition in Sarcoidosis: an Opportunity for Pathogenesis Directed Therapy
Status: Recruiting, Estimated PCD: 2024-12-31
Clinical trial
Yale Steroid Enhanced Versus Exparel Nerveblock TKA Randomized Controlled Trial (RCT) Study
Status: Recruiting, Estimated PCD: 2025-03-01
Clinical trial
AMPK-activation by Metformin in FSGS: AMP-FSGS
Status: Recruiting, Estimated PCD: 2027-11-01
Clinical trial
Imaging Traumatic Stress and Alcohol Use Disorder With [18F]Bavarostat
Status: Not yet recruiting, Estimated PCD: 2030-06-01
Clinical trial
SIMCAP (Surgery in Metastatic Carcinoma of Prostate): Phase 2.5 Multi-Institution Randomized Prospective Clinical Trial Evaluating the Impact of Cytoreductive Radical Prostatectomy Combined With Best Systemic Therapy on Oncologic and Quality of Life Outcomes in Men With Newly Diagnosed Metastatic Prostate Cancer
Status: Recruiting, Estimated PCD: 2024-10-31
Clinical trial
Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD: a Proof-of-concept Study of Stimulant-induced Dopamine Release Using [11C]-PHNO PET in Healthy Humans
Status: Completed, Estimated PCD: 2023-01-17
Clinical trial
Characterization of CB1 Receptors Using [11-C]OMAR in Opioid Use Disorder
Status: Recruiting, Estimated PCD: 2025-12-15
Clinical trial
A Pilot Study of Oral Azacitidine (CC-486) Epigenetic Priming and Maintenance in Adult AML Patients Eligible for Reduced Intensity Allogeneic Stem Cell Transplant
Status: Withdrawn, Estimated PCD: 2028-11-01
Clinical trial
Imaging the Neuroimmune System in PTSD With PET
Status: Active (not recruiting), Estimated PCD: 2023-05-30
Clinical trial
Genetics of Cannabis Use Disorder and Cannabinoid Response in Humans
Status: Not yet recruiting, Estimated PCD: 2028-12-31
Clinical trial
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I
Status: Recruiting, Estimated PCD: 2024-06-01
Clinical trial
Novel Combination of Belantamab Mafodotin and Elotuzumab to Enhance Therapeutic Efficacy in Multiple Myeloma
Status: Recruiting, Estimated PCD: 2025-01-01
Clinical trial
A Phase II Evaluation of Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2-SN-38 Antibody-drug Conjugate in Patients With Recurrent or Persistent Cervical Cancer
Status: Recruiting, Estimated PCD: 2026-06-01
Clinical trial
Imaging SV2A in Mood Disorders
Status: Recruiting, Estimated PCD: 2027-01-01
Clinical trial
Impact of Menthol on the Abuse Potential of Nicotine
Status: Completed, Estimated PCD: 2023-06-29
Clinical trial
Ultrasound Guided Emergency Physician Performed Erector Spinae Nerve Block for Rib Fracture Analgesia
Status: Not yet recruiting, Estimated PCD: 2025-01-01
Clinical trial
Anticoagulation in Intracerebral Hemorrhage (ICH) Survivors for Stroke Prevention and Recovery
Status: Recruiting, Estimated PCD: 2027-04-01
Clinical trial
Influence of Medication on Functional Connectivity
Status: Completed, Estimated PCD: 2022-06-02
Clinical trial
Renal Mechanistic Effects of Acute and Chronic Empagliflozin in Heart Failure
Status: Recruiting, Estimated PCD: 2024-11-01
Clinical trial
Effects of Repeated Dosing of Psilocybin on Obsessive-Compulsive Disorder: A Randomized, Waitlist-Controlled Study
Status: Recruiting, Estimated PCD: 2026-07-01
Clinical trial
Lidocaine Patches After Cesarean Section
Status: Completed, Estimated PCD: 2022-08-31
Clinical trial
Investigation of Cocaine Addiction Using mGluR5 PET and fMRI
Status: Completed, Estimated PCD: 2022-08-18
Clinical trial
Phase II Study to Evaluate Modified Folfirinox and Stereotactic Body Radiation Therapy in Non-metastatic Unresectable Pancreatic Adenocarcinoma
Status: Recruiting, Estimated PCD: 2024-08-01
Clinical trial
Combining Varenicline and Guanfacine for Smoking Cessation
Status: Recruiting, Estimated PCD: 2024-08-31
Clinical trial
A Phase I/Ib Study of APX005M in Combination With Nivolumab and Cabiralizumab in Patients With Advanced Melanoma, Non-small Cell Lung Cancer or Renal Cell Carcinoma Whose Disease Has Progressed on Anti-PD- 1/PD-L1 Therapy
Status: Active (not recruiting), Estimated PCD: 2022-01-05
Clinical trial
Digoxin In Treatment of Alcohol Associated Hepatitis (DIGIT-AlcHep)
Status: Recruiting, Estimated PCD: 2024-10-01
Clinical trial
Diagnosing and Targeting Mechanisms of Diuretic Resistance in Heart Failure
Status: Completed, Estimated PCD: 2020-01-23
Clinical trial
Diabetes Prevention With Lifestyle Intervention and Metformin Escalation
Status: Terminated, Estimated PCD: 2021-12-01
Clinical trial
Apremilast for Alcohol Use Disorder Treatment in Women and Men
Status: Recruiting, Estimated PCD: 2025-02-28
Clinical trial
Safety of Acute and Repeated Doses of Natural Medical Marijuana Products and Effects on Subjective and Physiological Responses to Stress and Pain
Status: Completed, Estimated PCD: 2023-12-15
Clinical trial
A Phase 2, Randomized, Double-Blind, Placebo-Controlled, Dose Titration Study to Assess the Safety, Tolerability, and Efficacy of Valbenazine for the Treatment of Trichotillomania in Adults
Status: Recruiting, Estimated PCD: 2025-10-15
Clinical trial
Exploration of Baseline Alterations on the Dopamine D2/D3 Receptor System and the Effects of Vitamin D in Opioid Use Disorder: an [11C]-PHNO Study
Status: Recruiting, Estimated PCD: 2024-06-01
Clinical trial
A Trial to Evaluate Target Occupancy of Scopolamine at the Muscarinic M1 Receptor
Status: Not yet recruiting, Estimated PCD: 2024-10-01
Clinical trial
Prazosin Treatment for Alcohol Use Disorder With Alcohol Withdrawal Symptoms
Status: Recruiting, Estimated PCD: 2026-06-30
Clinical trial
Office-based Methadone Versus Buprenorphine to Address Retention in Medication for Opioid Use Disorder Treatment - A Pragmatic Hybrid Effectiveness/Implementation Trial
Status: Recruiting, Estimated PCD: 2028-12-01
Clinical trial
Acetylcholine, Tobacco Smoking, Genes and Nicotinic Receptors
Status: Completed, Estimated PCD: 2021-12-01
Clinical trial
A Phase II Evaluation of Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2-SN-38 Antibody-drug Conjugate, in Patients With Persistent or Recurrent Endometrial Carcinoma
Status: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
Cognitive-Behavioral and Pharmacologic Treatment of Binge-Eating Disorder and Obesity
Status: Terminated, Estimated PCD: 2023-12-14
Clinical trial
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3
Status: Recruiting, Estimated PCD: 2025-07-31
Clinical trial
Adipose Dysfunction, Imaging, Physiology, and Outcomes With SGLT2i's for Sleep Apnea: The ADIPOSA Study
Status: Recruiting, Estimated PCD: 2027-09-01
Clinical trial
Multimodal Magnetoencephalography and Electroencephalography Exploration of the Acute Effects of THC Exposure on Neural Noise and Information Transmission Within Working Memory Networks
Status: Not yet recruiting, Estimated PCD: 2025-12-01
Clinical trial
Mechanistic Evaluation of Guanfacine on Drinking Behavior in Women and Men With Alcohol Use Disorders
Status: Recruiting, Estimated PCD: 2025-02-28
Clinical trial
PBR28 Brain Positron Emission Tomography Imaging With Lipopolysaccharide (LPS) Challenge for the Study of Microglia Function in Alzheimer's Disease
Status: Completed, Estimated PCD: 2022-07-27
Clinical trial
Cognitive-Behavioral and Pharmacologic (LDX) Treatment of Binge-Eating Disorder and Obesity
Status: Completed, Estimated PCD: 2023-09-13
Clinical trial
Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol
Status: Completed, Estimated PCD: 2020-11-19
Clinical trial
A Phase 2B, 8-week, Randomized, Double-Blind, Placebo-Controlled, Parallel Study to Evaluate Efficacy, Safety and Tolerability of the Fatty Acid Amide Hydrolase (FAAH) Inhibitor PF-04457845 in Adults With DSM5 Current Cannabis Use Disorder (CUD)
Status: Completed, Estimated PCD: 2022-07-25
Clinical trial
In Vivo Study of THC-induced Immune-genome Changes at Single Cell Solution in HIV-infected Humans
Status: Recruiting, Estimated PCD: 2025-06-30
Clinical trial
A Phase II Evaluation of Afatanib, an Irreversible Human Epidermal Growth Factor Receptor 2 (Her2/Neu) Tyrosine Kinase Inhibitor, in Patients With Persistent or Recurrent HER2-positive Uterine Serous Carcinoma
Status: Recruiting, Estimated PCD: 2024-07-01
Clinical trial
A Single Arm Open-label, Phase II Study of Sipuleucel-T With Bipolar Androgen Therapy in Men With Metastatic Castration-resistant Prostate Cancer
Status: Recruiting, Estimated PCD: 2027-12-01
Clinical trial
Treatment Targets for Inflamed Intracranial Atherosclerosis on Vessel Wall MRI
Status: Recruiting, Estimated PCD: 2024-11-27
Clinical trial
Examine the Feasibility of a Standardized Field Test for Marijuana Impairment: Laboratory Evaluations
Status: Completed, Estimated PCD: 2020-03-30
Clinical trial
Psilocybin - Induced Neuroplasticity in the Treatment of Major Depressive Disorder
Status: Active (not recruiting), Estimated PCD: 2021-07-08
Clinical trial
Imaging Glutamate Release From Alcohol
Status: Recruiting, Estimated PCD: 2025-12-01
Clinical trial
Transverse Abdominis Plane Block Using Liposomal Bupivacaine for Post-operative Cesarean Delivery Analgesia- Walking Towards Recovery
Status: Recruiting, Estimated PCD: 2025-05-30
Clinical trial
Atezolizumab and Bevacizumab in Combination With TACE for Patients With BCLC B HCC
Status: Recruiting, Estimated PCD: 2025-03-01
Clinical trial
Effect of Empagliflozin on Peritoneal and Kidney Function in End Stage Renal Disease
Status: Recruiting, Estimated PCD: 2024-12-31
Clinical trial
Regulating Blood Pressure During Recovery From Intracerebral Hemorrhage and Ischemic Stroke
Status: Recruiting, Estimated PCD: 2025-03-01
Clinical trial
A Pilot Study of Combination Immunotherapy With Ipilimumab and Nivolumab in Patients With Recurrent Extensive Stage Small Cell Lung Cancer (SCLC) Who Have Previously Received Platinum-based Chemotherapy
Status: Active (not recruiting), Estimated PCD: 2024-12-01
Clinical trial
Effects of Empagliflozin on Natriuresis and Volume Overload in Patients With Cirrhosis and Ascites
Status: Recruiting, Estimated PCD: 2025-09-01
Clinical trial
Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study II
Status: Active (not recruiting), Estimated PCD: 2024-12-01
Clinical trial
Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study I
Status: Active (not recruiting), Estimated PCD: 2024-12-01
Clinical trial
Efficacy and Mechanisms of Naltrexone+Bupropion for Binge Eating Disorder
Status: Completed, Estimated PCD: 2022-04-19
Clinical trial
Testing the Interactive Effects of Delta-9-Tetrahydrocannabinol and Pregnenolone
Status: Completed, Estimated PCD: 2019-06-24
Clinical trial
Safety and Efficacy of Psilocybin for the Treatment of Headache Disorders: Sub-Study II
Status: Terminated, Estimated PCD: 2023-06-27
Clinical trial
A Preliminary Test of Concurrent vs. Sequential Cessation of Dual Cigarette and E-cigarette Use on Behavior, Tobacco Toxicant Exposure, and Health Effects
Status: Recruiting, Estimated PCD: 2024-06-01
Clinical trial
Safety and Efficacy of BXCL501, a Sublingual Film Delivery of Dexmedetomidine for the Treatment of Acute Agitation in Schizophrenia
Status: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
A Pilot Study to Evaluate Biomarkers and Safety of Dapagliflozin Concomitant With Neoadjuvant Therapy for Patient With HER2-negative Early-stage Breast Cancer and Hyperinsulinemia
Status: Not yet recruiting, Estimated PCD: 2025-12-01
Clinical trial
Yale Steroid Enhanced Versus Exparel Nerveblock TKA Part 2
Status: Recruiting, Estimated PCD: 2025-03-01
Clinical trial
Behavioral and Pharmacological Treatments to Enhance Weight Outcomes After Metabolic and Bariatric Surgery
Status: Recruiting, Estimated PCD: 2027-01-12
Clinical trial
Pregnenolone for the Treatment of Alcohol Use Disorder
Status: Recruiting, Estimated PCD: 2028-07-31
Clinical trial
The Impact of AMPA Receptor Blockade on Ketamine's Anti-Suicidal Effects
Status: Recruiting, Estimated PCD: 2033-03-01
Clinical trial
Effects of IL-17A Inhibition on Idiopathic Subglottic Stenosis
Status: Not yet recruiting, Estimated PCD: 2026-11-01
Clinical trial
Reducing Adolescent Suicide Risk: Safety, Efficacy, and Connectome Phenotypes of Intravenous Ketamine
Status: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
Phase II Study of Mogamulizumab With DA-EPOCH in Patients With Aggressive T Cell Lymphoma
Status: Not yet recruiting, Estimated PCD: 2026-08-01
Clinical trial
Emergency Department-Initiated Buprenorphine Validation Network Trial
Status: Recruiting, Estimated PCD: 2024-07-31
Clinical trial
Novel in Vivo Synaptic Imaging in Experienced Meditators
Status: Recruiting, Estimated PCD: 2024-08-31
Clinical trial
Single-Arm Phase II Trial of Dual Inhibition of EGFR With Afatinib and Cetuximab With Correlative Studies in the Treatment of Advanced Squamous Cell Cancers of the Head and Neck
Status: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
The Role of Neuroactive Steroids in Stress, Alcohol Craving and Alcohol Use in Alcohol Use Disorders
Status: Completed, Estimated PCD: 2022-11-01
Clinical trial
Fibroids and Unexplained Infertility Treatment With Epigallocatechin Gallate; A Natural CompounD in Green Tea (FRIEND)
Status: Recruiting, Estimated PCD: 2025-12-30
Clinical trial
Age-dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-associated Thrombosis in Critically Ill Children
Status: Recruiting, Estimated PCD: 2026-04-30
Clinical trial
Understanding Effects of Cannabis Use and Abstinence on Neural Glutamate Homeostasis
Status: Recruiting, Estimated PCD: 2028-02-28
Clinical trial
Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis - A Prospective Clinical Trial
Status: Recruiting, Estimated PCD: 2026-06-30
Clinical trial
Assessment of Cognitive Function Before and After Conversion From Immediate Release Tacrolimus to Envarsus XR
Status: Recruiting, Estimated PCD: 2024-07-01
Clinical trial
Cannabidiol Pharmacotherapy for Comorbid Opioid Addiction and Chronic Pain
Status: Recruiting, Estimated PCD: 2024-06-01
Clinical trial
The Effect of Glucagon on Rates of Hepatic Mitochondrial Oxidation and Pyruvate Carboxylase Flux in Man Assessed by Positional Isotopomer NMR Tracer Analysis (PINTA)
Status: Completed, Estimated PCD: 2023-11-01
Clinical trial
Functional Neuroimaging of Alcoholism Vulnerability: Probing Glutamate and Reward, Using the mGluR5 Inhibitor Mavoglurant
Status: Recruiting, Estimated PCD: 2025-06-30
Clinical trial
A Phase 4, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Assess the Efficacy of Ocrelizumab in Patients With Radiologically Isolated Syndrome
Status: Terminated, Estimated PCD: 2023-06-12
Clinical trial
Physiologic Markers of Cardiometabolic Risk in People With Type 1 Diabetes
Status: Recruiting, Estimated PCD: 2028-06-01
Clinical trial
Pharmacokinetics and Pharmacodynamics of Oral and Vaporized Delta-9-Tetrahydrocannabinol (THC) in Older Adults
Status: Recruiting, Estimated PCD: 2025-04-30
Clinical trial
Temozolomide and Olaparib for O6-Methylguanine DNA Methyltransferase Promoter Hypermethylated Colorectal Cancer
Status: Completed, Estimated PCD: 2022-01-06
Clinical trial
Integrated eHealth for HIV and Substance Use Disorders in Justice Involved Women
Status: Recruiting, Estimated PCD: 2027-04-01
Clinical trial
A Randomized Active Placebo Controlled Trial of Ketamine in Borderline Personality Disorder
Status: Terminated, Estimated PCD: 2022-05-06
Clinical trial
Ertugliflozin in Chronic Heart Failure: Cardio-renal and Diuretic Effects
Status: Recruiting, Estimated PCD: 2025-01-31
Clinical trial
Probing the Cannabinoid System in Individuals With a Family History of Psychosis
Status: Active (not recruiting), Estimated PCD: 2024-06-01
Clinical trial
PET Imaging of Synaptic Density Combined With Neuroimmunologic Measures to Reveal Mechanisms of HIV Neuropathogenesis During ART
Status: Recruiting, Estimated PCD: 2027-12-01
Clinical trial
Examine the Feasibility of a Standardized Field Test for Marijuana Impairment: Laboratory Evaluations II
Status: Active (not recruiting), Estimated PCD: 2025-02-01
Clinical trial
Diluted Insulin in Young Children: Bigger Volumes for Smaller Patients
Status: Completed, Estimated PCD: 2023-06-30
Clinical trial
Aspirin to Prevent Preeclampsia in Women With Elevated Blood Pressure and Stage 1 Hypertension (ASPPIRE)
Status: Terminated, Estimated PCD: 2022-06-22
Clinical trial
Mechanisms of Diuretic Resistance in Heart Failure, Aim 2
Status: Recruiting, Estimated PCD: 2027-06-01
Clinical trial
Safety, Feasibility, and Tolerability of Psilocybin Treatment for Individuals With Functional Impairment Related to Mood, Anxiety, Trauma and/or Addiction Symptoms: An Open-label Proof-of-concept Study
Status: Not yet recruiting, Estimated PCD: 2027-07-01
Clinical trial
Effect of Cannabidiol on Microglial Activation and Central Pain-Sensitization
Status: Recruiting, Estimated PCD: 2024-08-31
Clinical trial
Efficacy, Safety, and Tolerability of MoviPrep® Versus GoLYTELY® Bowel Preparation in Hospitalized Patients Undergoing Colonoscopy: a Randomized Control Trial
Status: Recruiting, Estimated PCD: 2024-07-01
Clinical trial
Emergency Department-Initiated Medications for Alcohol Use Disorder
Status: Not yet recruiting, Estimated PCD: 2027-12-01
Clinical trial
A Single Center, Pilot Study of Induced Hypertension for Minimizing Infarct Progression in Patients With Acute Large-vessel Occlusion Ischemic Stroke Undergoing Endovascular Therapy
Status: , Estimated PCD: 2024-06-01
Clinical trial
Examining the Effect of Burosumab on Muscle Function Using MR Spectroscopy
Status: Completed, Estimated PCD: 2022-08-25
Clinical trial
Mechanisms and Interventions Addressing Accelerated Cardiovascular Disease Risk in Women With Endometriosis
Status: Recruiting, Estimated PCD: 2025-08-30
Clinical trial
Real-World Data to Assess Variation in Opioid Prescribing and Use for Acute Pain in Diverse Populations
Status: Completed, Estimated PCD: 2023-11-30
Clinical trial
Examine the Feasibility of a Standardized Field Test for Marijuana and Alcohol Impairment: Laboratory Evaluations
Status: Active (not recruiting), Estimated PCD: 2024-04-01
Clinical trial
1311013082
Status: Completed, Estimated PCD: 2022-08-14
Clinical trial
Mechanism and Effects of Manipulating Chloride Homeostasis in Stable Heart Failure
Status: Recruiting, Estimated PCD: 2025-06-01
Clinical trial
Randomized Phase II Evaluation of Carboplatin/Paclitaxel With and Without Trastuzumab (Herceptin) in HER2/Neu+ Patients With Advance/Recurrent Uterine Serous Papillary Carcinoma
Status: Completed, Estimated PCD: 2022-06-30
Clinical trial
Impact of Recurrent Hypoglycemia on Brain Ketone Metabolism in Type 1 Diabetes
Status: Completed, Estimated PCD: 2022-04-04
Clinical trial
Neuroimmune Mechanisms in Obesity
Status: Withdrawn, Estimated PCD: 2033-01-01
Clinical trial
The Effects of Dronabinol in Opioid-Related Outcomes
Status: Recruiting, Estimated PCD: 2024-10-30
Clinical trial
The Interaction of Flavor With Nicotine Form in Adult Smokers
Status: Completed, Estimated PCD: 2022-01-10
Clinical trial
Testing Restoring Effects of Vitamin D on the Dopamine System: A Human Laboratory Study Among Cocaine Users.
Status: Terminated, Estimated PCD: 2020-01-17
Clinical trial
Posttraumatic Stress Disorder (PTSD) Treatment: Using Ketamine to Enhance Memory Reconsolidation and Extinction of Overgeneralized Fear in Individuals Diagnosed With PTSD
Status: Recruiting, Estimated PCD: 2030-08-01
Clinical trial
Pilot Analysis of the Association Between Types of Anesthetic and Outcomes in Transfemoral Aortic Valve Replacement
Status: Completed, Estimated PCD: 2017-05-01
Clinical trial
Botulinum Toxin-A for Hidradenitis Suppurativa
Status: Not yet recruiting, Estimated PCD: 2024-07-01
Clinical trial
Ketamine for Severe Adolescent Depression: Intermediate-term Safety and Efficacy
Status: Terminated, Estimated PCD: 2019-12-18
Clinical trial
Mechanisms of Diuretic Resistance in Heart Failure, Aim 3
Status: Not yet recruiting, Estimated PCD: 2028-03-01
Clinical trial
Psilocybin Treatment in Obsessive-Compulsive Disorder: a Preliminary Efficacy Study and Exploratory Investigation of Neural Correlates.
Status: Active (not recruiting), Estimated PCD: 2024-08-30
Clinical trial
A Phase I Study of APX005M in Combination With Nivolumab and Ipilimumab in Treatment Naïve Patients With Advanced Melanoma or Renal Cell Carcinoma
Status: Recruiting, Estimated PCD: 2024-08-01
Clinical trial
Novel Approach of Combined Lithium-Ketamine Therapy in Bipolar Depression: To Preserve Efficacy and Minimize Adverse Effects
Status: Withdrawn, Estimated PCD: 2013-01-01
Clinical trial
Ziprasidone vs Placebo in the Prevention of Psychosis Among Symptomatic Adolescents and Young Adults at Prodromal Risk
Status: Completed, Estimated PCD: 2012-11-01
Clinical trial
Progesterone Treatment in Reducing Trauma and Alcohol Induced Craving in Individuals Diagnoses With Alcohol Dependence (AD) and Post-tramatic Stress Disorder (PTSD).
Status: Completed, Estimated PCD: 2021-09-08
Clinical trial
Translational Neuroscience Optimization of GlyT1 Inhibitor
Status: Completed, Estimated PCD: 2018-12-01
Clinical trial
Real-World Effectiveness of Perinatal RSV Immunoprophylaxis
Status: Not yet recruiting, Estimated PCD: 2028-12-30
Clinical trial
Buprenorphine Treatment for Prescription Opioid Dependence
Status: Completed, Estimated PCD: 2022-02-01
Clinical trial
Behavioral and Pharmacologic Treatment of Binge Eating and Obesity
Status: Completed, Estimated PCD: 2021-07-23
Clinical trial
Impulsivity and Stimulant Administration
Status: Completed, Estimated PCD: 2014-05-01
Clinical trial
Norepinephrine Transporter Imaging in Addiction Disorders
Status: Withdrawn, Estimated PCD: 2012-07-01
Clinical trial
Imaging Extrastriatal Dopamine Release in Tobacco Smokers and Nonsmokers
Status: Completed, Estimated PCD: 2017-12-01
Clinical trial
A Phase One Study Investigating the Tolerability and Effects of AZD0530 on Functional Neuroimaging Responses in Individuals With or Without a Family History of Alcoholism
Status: Completed, Estimated PCD: 2019-04-26
Clinical trial
FAAH-Inhibitor for Cannabis Dependence
Status: Completed, Estimated PCD: 2016-03-11
Clinical trial
FAAH Availability in Psychiatric Disorders: A PET Study
Status: Terminated, Estimated PCD: 2021-06-30
Clinical trial
Inhibition of Sterile Inflammation by Digoxin
Status: Completed, Estimated PCD: 2023-05-05
Clinical trial
The Potential Therapeutic Effects of Psychedelic, N, N-dimethyltryptamine (DMT), on Alcohol Use Disorder (AUD)
Status: Not yet recruiting, Estimated PCD: 2025-09-30
Clinical trial
The Effects of MDMA on Prefrontal and Amygdala Activation in Posttraumatic Stress Disorder
Status: Withdrawn, Estimated PCD: 2028-01-01
Clinical trial
Colchicine/Statins for the Prevention of COVID-19 Complications (COLSTAT) Trial
Status: Completed, Estimated PCD: 2022-03-30
Clinical trial
An Open-Label, Single-Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Receptor Occupancy of BMS-984923
Status: Completed, Estimated PCD: 2022-04-24
Clinical trial
CYstic Fibrosis bacterioPHage Study at Yale (CYPHY): A Single-site, Randomized, Double-blind, Placebo-controlled Study of Bacteriophage Therapy YPT-01 for Pseudomonas Aeruginosa Infections in Adults With Cystic Fibrosis
Status: Completed, Estimated PCD: 2023-05-26
Clinical trial
GLP-1 Agonism for Blocking Cocaine Euphoria and Self-Administration
Status: Completed, Estimated PCD: 2018-08-01
Clinical trial
Use of Antibiotic Based Irrigation for Ureteroscopic Treatment of Urolithiasis
Status: Not yet recruiting, Estimated PCD: 2025-06-01
Clinical trial
Vitamin D as a Therapeutic Adjunct in the Stimulant Treatment of ADHD: a Proof-of-concept Tele-health Study of Stimulant-induced Improvement in Neurocognitive Functioning.
Status: Terminated, Estimated PCD: 2020-09-29
Clinical trial
Postoperative Dexamethasone on Post-Cesarean Pain in Patients Using Medication Assisted Treatment (MAT)
Status: Recruiting, Estimated PCD: 2024-11-30
Clinical trial
Toward a Computationally-Informed, Personalized Treatment for Hallucinations
Status: Recruiting, Estimated PCD: 2024-08-20
Clinical trial
A Multi-Center Phase 0/I Trial of Anti-TIGIT Antibody AB154 in Combination With Anti-PD-1 Antibody AB122 for Recurrent Glioblastoma.
Status: Recruiting, Estimated PCD: 2025-02-28
Clinical trial
1212011268
Status: Completed, Estimated PCD: 2014-06-01
Clinical trial
Pharmacokinetics and Hepatic Safety of EGCG
Status: Completed, Estimated PCD: 2022-01-31
Clinical trial
1403013567
Status: Terminated, Estimated PCD: 2014-06-09
Clinical trial
Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II
Status: Recruiting, Estimated PCD: 2024-06-01
Clinical trial
Mechanisms for Restoration of Hypoglycemia Awareness
Status: Completed, Estimated PCD: 2023-08-14
Clinical trial
Treatment of High-Grade Pre-Neoplastic Cervical Lesions (CIN 2/3) Using a Novel "Prime and Pull" Strategy
Status: Completed, Estimated PCD: 2022-05-24
Clinical trial
ECMO Hemostatic Transfusions in Children
Status: Recruiting, Estimated PCD: 2025-04-01
Clinical trial
Efficacy of Laparoscopic-assisted Transversus Abdominus Plane (TAP) Block in Minimally Invasive Gynecologic Surgeries: A Prospective, Randomized Control Trial.
Status: Completed, Estimated PCD: 2023-10-15
Clinical trial
Mechanisms of Diuretic Resistance in Heart Failure
Status: Recruiting, Estimated PCD: 2026-05-01
Clinical trial
Varenicline for Treatment of E-cigarette Dependence
Status: Completed, Estimated PCD: 2023-09-01
Clinical trial
The Neural Correlates of Cannabis Use
Status: Completed, Estimated PCD: 2022-04-27
Clinical trial
Influence of Genetics Variants on the Pharmacokinetics and Pharmacodynamics of Combined Oral Contraceptive Pill Users
Status: Not yet recruiting, Estimated PCD: 2028-05-01
Abstract
Determinants of resistance to nivolumab (nivo) monotherapy investigated through genomic and transcriptomic analysis of renal cell carcinoma (RCC) tumors from the HCRN GU16-260 study.
Org: School of Medicine, Zhejiang University, Hangzhou, China, Yale University, New Haven, CTI BioPharma, Keck School of Medicine of the University of Southern California,
Abstract
A multifaceted approach to wellness in a hematology/oncology fellowship program.
Org: Yale New Haven Hospital, Yale Cancer Center, Yale School of Medicine, New Haven, CT, Yale School of Medicine, Yale University,
Abstract
Somatic mutations in tumor-adjacent normal breast tissue in young women with high risk family history.
Org: Yale School of Medicine, Silesian University of Technology, Yale University, Yale Cancer Center, Yale School of Medicine, New Haven, CT,
Abstract
Role of HLA class-I antigen peptide loading complex components in immune evasion and treatment sensitivity in human lung cancer.
Org: Yale University, Harvard Cancer Center,
Abstract
A phase 2 study of the WEE1 inhibitor AZD1775 in SETD2-deficient advanced solid tumor malignancies.
Org: University of California San Francisco, Vanderbilt University Medical Center, Dana-Farber Cancer Institute, The University of Texas MD Anderson Cancer Center, Stem Cell Transplantation Rsch, Houston, TX, Robert H. Lurie Comprehensive Cancer Center of Northwestern University,
Abstract
Pathologic concordance rate and outcomes by histologic subtype in advanced papillary renal cell (pRCC) carcinoma: An analysis from the SWOG S1500 (PAPMET) trial.
Org: City of Hope Comprehensive Cancer Center, SWOG Statistics and Data Management Center, Seattle, WA, University of Washington and Fred Hutchinson Cancer Research Centre, Yale School of Medicine, Yale University,
Abstract
Characterization of the immunophenotype and tumor specificity of CD8+ T-cells in chromophobe renal cell carcinoma (ChRCC) and renal oncocytic neoplasms.
Org: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, St. Elizabeth's Medical Center, Brighton, MA,
Abstract
The Brown University cancer prevention & survivorship curriculum: A case study on program development in an internal medicine residency.
Org: Brown University/Lifespan Hospitals, University of Texas MD Anderson Cancer Center, Yale University, Legorreta Cancer Center at Brown University, Brown University - Lifespan Cancer Institute,
Abstract
Association of alterations in multiple tumor suppressor genes with poor outcomes in patients with EGFR-mutant lung cancer.
Org: Yale School of Medicine, New Haven, CT, Yale Cancer Center, Yale School of Medicine, New Haven, CT, Plantsville, CT, Yale University,
Abstract
Phase II study of cabozantinib (Cabo) with nivolumab (Nivo) and ipilimumab (Ipi) in advanced renal cell carcinoma with variant histologies (RCCvh).
Org: Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, Department of Data Sciences, Winship Cancer Institute of Emory University,
Abstract
Discovery of gene fusions in driver-negative NCI-MATCH screening samples.
Org: Massachusetts General Hospital/Harvard Medical School, Frederick National Laboratory for Cancer Research, Yale University, Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, MD, National Cancer Institute, Vilnius, Lithuania,
Abstract
Oral paclitaxel and dostarlimab with or without trastuzumab in early-stage, high-risk breast cancer: Results from the neoadjuvant ISPY 2 TRIAL.
Org: University of California San Diego Medical Center, La Jolla, CA, Wake Forest University School of Medicine, University of California San Francisco, University of Rochester Medical Center Department of Medical Oncology, University of Alabama at Birmingham Department of Hematology, Birmingham, AL,
Abstract
MammaPrint Index as a predictive biomarker for neoadjuvant chemotherapy response and outcome in patients with HR+HER2- breast cancer in NBRST.
Org: Dallas Surgical Group, Bon Secours Cancer Institute at St. Francis, Yale University, Lenox Hill Hospital, Northwell Health, New Hyde Park, NY,
Abstract
Racial and ethnic disparities in quality of diagnostic evaluation for uterine cancer among Medicare patients.
Org: Yale University, Columbia University - Mailman School of Public Health,
Abstract
A phase 2 trial of mosunetuzumab with lenalidomide augmentation as first-line therapy for follicular (FL) and marginal zone lymphoma (MZL).
Org: Brown University - Lifespan Cancer Institute, Yale University, Rhode Island Hospital, Lifespan Oncology Clinical Research, Brown University Oncology Research Group,
Abstract
The impact of genetic predisposition to depression on quality of life in patients with head and neck cancer immediately post-treatment: A longitudinal study.
Org: McGill University Health Center, McGill University - Lady Davis Institute for Medical Research, Jewish General Hospital Stroll Cancer Prevention Centre, Yale University,
Abstract
Molecular predictors and immunomodulatory role of dual checkpoint inhibitor blockade using ipilimumab/nivolumab in patients with extensive stage small cell lung cancer.
Org: Yale University School of Medicine, Ocean Genomics, Yale University Dept of Pathology, Yale School of Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT,
Abstract
Biomarkers of response to first-line nivolumab therapy in patients with advanced renal cell carcinoma (RCC) enrolled in the HCRN GU16-260 trial.
Org: Brigham and Women's Hospital/Massachusetts General Hospital, Dana-Farber Cancer Institute, Massachusetts General Hospital, Harvard Medical School, Yale University,
Abstract
The impact of oncology hospitalist utilization on resident education.
Org: Yale University, Yale School of Medicine, Smilow Cancer Hospital, Yale New Haven Hospital, Yale Cancer Center/Smilow Cancer Hospital at Yale New Haven Health,
Abstract
ACTION-1 phase Ib/3 trial of RYZ101 in somatostatin receptor subtype 2–expressing (SSTR2+) gastroenteropancreatic neuroendocrine tumors (GEP-NET) progressing after 177Lu somatostatin analogue (SSA) therapy: Initial safety analysis.
Org: Advanced Molecular Imaging and Therapy, Hoag Family Cancer Institute and University of Southern California, MD Anderson Cancer Center, Moffitt Cancer Center and Research Institute, Nebraska Cancer Specialists,
Abstract
Brentuximab vedotin + AVD for newly diagnosed classic Hodgkin lymphoma (cHL): Incidence and management of peripheral neuropathy in a multi-institution cohort.
Org: Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, University of Colorado Denver Anschutz Medical Center, Aurora, CO,
Abstract
The association between systemic anticancer therapy (SACT) at the end of life (EOL) and acute care use among patients treated at oncology practices participating in the Oncology Care Model (OCM).
Org: Yale School of Medicine, Everett Castle, LLC, Integra Connect, Yale University,
Abstract
Demographic and clinical factors associated with cardiovascular events in elderly long-term survivors of breast cancer.
Org: Yale University, Cancer Outcomes, Public Policy and Effectiveness Research Center, Public Policy and Effectiveness Research (COPPER) Center, Yale School of Medicine, Thomas Jefferson University,
Abstract
Evaluating differences in cancer survivorship care plans experienced by cancer survivors with disabilities.
Org: Cancer Outcomes, Public Policy, and Effectiveness Research (COPPER) Center, Yale University, Yale University School of Nursing,
Abstract
Relations between mutant KRAS and TP53 subtypes and other co-mutations in pancreatic cancer.
Org: Bridgeport Hospital, Yale New Haven Health, University of Pittsburgh, School of Medicine, Yale University Dept of Pathology, Yale University,
Abstract
Trends in breast cancer death by stage at diagnoses in 2000-2018.
Org: Yale Cancer Center, Yale School of Medicine, New Haven, CT, New Haven, CT, Silesian University of Technology, Gliwice, Poland, Yale University,
Abstract
Peripheral blood immune cell and cytokine profiling of patients receiving corticosteroids for immune checkpoint inhibitor-related adverse events: Steroid dose and duration.
Org: Yale University School of Medicine, Yale Cancer Center, Yale School of Medicine, New Haven, CT, Yale University, Yale School of Public Health,
Abstract
Racioethnic differences in missing data in the National Cancer Database: A window into inequities in cancer care.
Org: Duke University Medical Center, Yale University, University of Pennsylvania Health System,
Abstract
Effect of durable hematocrit control and minimal thrombotic risk in real-world polycythemia vera patients treated with ruxolitinib.
Org: Levine Cancer Institute Atrium Health, Levine Cancer Institute, Department of Hematologic Malignancies and Blood Disorders, Yale School of Medicine, Yale University,
Abstract
The impact of receipt of systemic anticancer therapy (SACT) near the end of life (EOL) on cost among oncology practices participating in CMS' Oncology Care Model (OCM).
Org: Yale School of Medicine, Everett Castle, LLC, Integra Connect, Yale University,
Clinical trial
Mechanistic Studies of Psilocybin in Headache Disorders
Status: Not yet recruiting, Estimated PCD: 2026-09-30
Clinical trial
Translational Neuroscience Optimization of GlyT1 Inhibitor
Status: Completed, Estimated PCD: 2018-12-01