Product
Cyclosporine
Aliases
27-400, Ciclosporin, CsA, CSA, Cyclosporin (10 other aliases)
Name
Neoral
INN Name
Cyclosporine
FDA Approved
Yes
44 clinical trials
2 organizations
83 indications
3 documents
Indication
HealthyIndication
Severe Aplastic AnemiaIndication
chronic kidney diseaseIndication
Aplastic AnemiaIndication
Membranous NephropathyIndication
LeukemiaIndication
lymphomaIndication
Myelodysplastic SyndromesIndication
hematologic malignanciesIndication
Myeloid MalignancyIndication
Acute Lymphoblastic LeukemiaIndication
Acute Myeloid LeukemiaIndication
Chronic Myelomonocytic LeukemiaIndication
Myelodysplastic SyndromeIndication
Recurrent Acute Myeloid LeukemiaIndication
Recurrent Mixed Phenotype Acute LeukemiaIndication
Mixed Phenotype Acute LeukemiaIndication
Dry EyeIndication
Colorectal CancerIndication
Solid TumorIndication
Colorectal cancerIndication
Takotsubo cardiomyopathyIndication
Myeloproliferative DisorderIndication
Non-Hodgkin LymphomaIndication
Hodgkin lymphomaIndication
RetinoblastomaIndication
Myeloproliferative DisordersIndication
Chronic Myelogenous LeukemiaIndication
COVID-19Indication
Aggressive Non-Hodgkin LymphomaIndication
Chronic Lymphocytic LeukemiaIndication
Diffuse Large B-Cell LymphomaIndication
mantle cell lymphomaIndication
Prolymphocytic LeukemiaIndication
BCR-ABL1-positiveIndication
Hodgkin LymphomaIndication
Multiple MyelomaIndication
Small Lymphocytic LymphomaIndication
Waldenstrom MacroglobulinemiaIndication
Hematologic and Lymphocytic DisorderIndication
nephrotic syndromeIndication
Dry Eye SyndromeIndication
Hodgkin's LymphomaIndication
Stevens-Johnson SyndromeIndication
Toxic Epidermal NecrolysisIndication
MyelofibrosisIndication
Hemophagocytic SyndromeIndication
Renal Allograft RecipientsIndication
Hepatitis CIndication
Multiple Myeloma in RelapseIndication
RefractoryIndication
severe acute respiratory syndromeIndication
Pure Red Cell AplasiaIndication
AcquiredIndication
Acute Biphenotypic LeukemiaIndication
Lung TransplantIndication
AllograftsIndication
Anaplastic Large Cell LymphomaIndication
Burkitt lymphomaIndication
Chronic Myeloid LeukemiaIndication
Lymphoblastic LymphomaIndication
Refractory Chronic Lymphocytic LeukemiaIndication
Follicular LymphomaIndication
Marginal Zone LymphomaIndication
ProteinuriaIndication
autoimmune diseaseIndication
Glomerular DiseaseIndication
Membranous nephropathyIndication
Thrombotic Thrombocytopenic PurpuraIndication
Sickle Cell DiseaseIndication
Graft-Versus-Host DiseaseIndication
Sjögren's syndromeClinical trial
A Phase 1, Open-Label, Drug Interaction Study to Investigate the Effect of Multiple Doses of Cyclosporine on the Pharmacokinetics of LY3502970 in Healthy ParticipantsStatus: Completed, Estimated PCD: 2023-01-17
Clinical trial
A Three-Part Phase 1 Study to Evaluate the Potential Drug Interactions Between ALXN2050 and Cyclosporine, Tacrolimus, and Mycophenolate Mofetil in Healthy Adult ParticipantsStatus: Completed, Estimated PCD: 2022-03-21
Clinical trial
Two Arm Bridging Study to Evaluate the Efficacy of Romiplostim in the Treatment of Adult Severe Aplastic Anemia Participants Who Are Either Previously Untreated With IST or Refractory to ISTStatus: Withdrawn, Estimated PCD: 2025-02-25
Clinical trial
An Open-label, 3-Treatment, 3-Period, Fixed Sequence Study in Healthy Subjects to Assess the Pharmacokinetics of Verinurad and Allopurinol When Administered Alone, and in Combination With Single Doses of Cyclosporine or RifampicinStatus: Completed, Estimated PCD: 2020-11-23
Clinical trial
SOAR, Interventional Phase II Single-arm Study to Assess Efficacy and Safety of Eltrombopag Combined With Cyclosporine as First Line Therapy in Adult Patients With Severe Acquired Aplastic AnemiaStatus: Completed, Estimated PCD: 2020-11-03
Clinical trial
A Multicenter, Randomized, Controlled, Open Phase Ib/ Ⅱ Study Evaluating the Efficacy and Safety of Recombinant Humanized Monoclonal Antibody MIL62 Injection in the Treatment of Primary Membranous Nephropathy.Status: Recruiting, Estimated PCD: 2024-11-01
Clinical trial
A Phase Ⅲ Clinical Study to Evaluate the Safety and Efficacy of MIL62 Injection in Participants With Primary Membranous NephropathyStatus: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
Allogeneic Stem Cell Transplantation for Patients With Hematological Malignancies Using Multiple Unrelated Cord Blood UnitsStatus: Active (not recruiting), Estimated PCD: 2009-11-11
Clinical trial
A Phase II Pediatric Study of a Graft-VS.-Host Disease (GVHD) Prophylaxis Regimen With no Calcineurin Inhibitors After Day +60 Post First Allogeneic Hematopoietic Cell Transplant for Hematological MalignanciesStatus: Recruiting, Estimated PCD: 2026-04-01
Clinical trial
A Study Evaluating Escalating Doses of 211^At-Labeled Anti-CD45 MAb BC8-B10 (211^At-BC8-B10) Followed by Allogeneic Hematopoietic Cell Transplantation for High-Risk Acute Myeloid Leukemia (AML), Acute Lymphoblastic Leukemia (ALL), or Myelodysplastic Syndrome (MDS)Status: , Estimated PCD: 2023-01-13
Clinical trial
The Effect of Topical 0.05% Cyclosporine Eye Drops on Post-refractive Surgery Dry EyeStatus: Recruiting, Estimated PCD: 2023-12-31
Clinical trial
Early Initiation of Oral Therapy With Cyclosporine and Eltrombopag for Treatment Naive Severe Aplastic Anemia (SAA)Status: Recruiting, Estimated PCD: 2025-03-01
Clinical trial
A Phase IB Study of the Combination of AZD6244 Hydrogen Sulfate (Selumetinib) and Cyclosporin A (CsA) in Patients With Advanced Solid Tumors With an Expansion Cohort in Metastatic Colorectal CancerStatus: Active (not recruiting), Estimated PCD: 2017-01-31
Clinical trial
Tear Film Markers in Dry Eye Syndrome: Impact of Immunomodulatory TherapyStatus: Withdrawn, Estimated PCD: 2023-12-08
Clinical trial
Cyclosporine In Takotsubo Syndrome (CIT) TrialStatus: Not yet recruiting, Estimated PCD: 2026-10-01
Clinical trial
CLAG-M or FLAG-Ida Chemotherapy Followed Immediately by Related/Unrelated Reduced-Intensity Conditioning (RIC) Allogeneic Hematopoietic Cell Transplantation for Adults With Myeloid Malignancies at High Risk of Relapse: A Phase 1 StudyStatus: Recruiting, Estimated PCD: 2025-12-31
Clinical trial
A Phase II Study of IL-6 Receptor Blockade to Ameliorate Acute Graft Versus Host Disease and Early Toxicity After Double Unit Cord Blood Transplantation in Adults With Hematologic Malignancies.Status: Active (not recruiting), Estimated PCD: 2025-02-07
Clinical trial
Multicenter Phase II Study for International Intraocular Retinoblastoma Classification Groups B, C & D Tumors Treated With Carboplatin-Etoposide-Vincristine-Cyclosporine-Focal Therapy Multimodality Protocol (OCRN Multicenter RB 2003)Status: Active (not recruiting), Estimated PCD: 2016-04-20
Clinical trial
Non-Myeloablative Allogeneic Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Hematologic Malignancies in High Risk Patients and in Patients With Debilitating Hematologic DiseasesStatus: Completed, Estimated PCD: 2018-12-14
Clinical trial
Study on the Efficacy and Safety of Anti-CD25 rhMAb in the Treatment of Steroid-Refractory Chronic Graft-Versus-Host Disease (cGVHD) of the Liver Following Allogeneic Hematopoietic Stem Cell TransplantatioStatus: Not yet recruiting, Estimated PCD: 2027-12-31
Clinical trial
I-SPY COVID TRIAL: An Adaptive Platform Trial to Reduce Mortality and Ventilator Requirements for Critically Ill PatientsStatus: Recruiting, Estimated PCD: 2028-07-31
Clinical trial
A Randomized Phase II Study to Compare the Net Clinical Benefit of Cyclosporine and Sirolimus Combined With MMF or Post-Transplant Cyclophosphamide as GVHD Prophylaxis After HLA-Matched or HLA-Mismatched Unrelated G-CSF Mobilized Blood Cell Transplantation Using Nonmyeloablative or Reduced Intensity Conditioning for Patients With Hematologic MalignanciesStatus: Recruiting, Estimated PCD: 2026-10-11
Clinical trial
Effect of Obesity on Cyclosporine Blood Trough Level in Nephrotic Syndrome PatientsStatus: Recruiting, Estimated PCD: 2024-02-01
Clinical trial
Effects of CEQUA™ on Objective and Subjective Dry Eye Findings Associated With Sjogren's SyndromeStatus: Completed, Estimated PCD: 2024-03-21
Clinical trial
Intracanalicular Dexamethasone Used in Conjunction With Restasis (Cyclosporine Ophthalmic Emulsion) for the Treatment of Signs and Symptoms of Dry Eye Disease as Compared to Restasis With Lotemax (Loteprednol Etabonate Ophthalmic Suspension 0.5%) and Restasis Monotherapy.Status: Completed, Estimated PCD: 2022-02-16
Clinical trial
A Phase I Trial of Brentuximab Vedotin Plus MDR1 Inhibitors in Relapsed/Refractory Hodgkin LymphomaStatus: Completed, Estimated PCD: 2022-05-24
Clinical trial
NATIENS: A Phase III Randomized Double-Blinded Placebo Controlled Study to Determine the Optimal Management and Mechanisms of Stevens-Johnson Syndrome and Toxic Epidermal NecrolysisStatus: Recruiting, Estimated PCD: 2027-08-01
Clinical trial
Phase II Study of Horse Anti-Thymocyte Globulin (hATG), Cyclosporine, Methylprednisolone, and GCSF (Filgrastim or Pegfilgrastim) in Patients With Aplastic Anemia (AA), or Low/Int-1 Risk Myelodysplastic Syndrome (MDS)Status: Recruiting, Estimated PCD: 2026-06-30
Clinical trial
A Multi-centre Phase II Trial of GVHD Prophylaxis Following Unrelated Donor Stem Cell Transplantation Comparing Thymoglobulin vs. Calcineurin Inhibitor or Sirolimus-based Post-transplant CyclophosphamideStatus: Recruiting, Estimated PCD: 2026-01-01
Clinical trial
A Randomized Controlled Study of High-dose Cyclophosphamide Induction Therapy in Adult Patients With HLHStatus: Recruiting, Estimated PCD: 2026-04-20
Clinical trial
A Prospective, Open-label, Multicenter, Randomized Study to Evaluate the Benefits and Risks of Conversion of Existing Adolescent Renal Allograft Recipients Aged 12 to Less Than 18 Years of Age to a Belatacept-based Immunosuppressive Regimen as Compared to Continuation of a Calcineurin Inhibitor-based Regimen, and Their Adherence to Immunosuppressive MedicationsStatus: Recruiting, Estimated PCD: 2026-05-25
Clinical trial
Cyclosporine in Hepatitis C Infection Viral Clearance Following Liver TransplantationStatus: Completed, Estimated PCD: 2008-05-01
Clinical trial
A Single-arm, Prospective Study of Cyclosporine in Combination With Carfilzomib and Dexamethasone in Patients With Relapsed Multiple Myeloma Refractory to Carfilzomib With High Expression of the Peptidylprolyl Isomerase A (PPIA) Gene in Myeloma CellsStatus: Recruiting, Estimated PCD: 2024-04-01
Clinical trial
The Efficacy of Immunosuppressive Therapy Combined With Cord Blood Transfusion in Treatment of Severe Aplastic AnemiaStatus: Completed, Estimated PCD: 2021-12-01
Clinical trial
Randomized Phase IIa Clinical Trial Of Cyclosporine For The Treatment Of COVID-19(+) Non-ICU Hospital InpatientsStatus: Completed, Estimated PCD: 2021-12-10
Clinical trial
Sirolimus Treatment for Newly Diagnosed Primary Acquired Pure Red Cell Aplasia: a Single Center Prospective StudyStatus: Completed, Estimated PCD: 2022-07-30
Clinical trial
A Phase II Study of Reduced Intensity Allogeneic Bone Marrow Transplant for the Treatment of Myelodysplastic SyndromesStatus: Completed, Estimated PCD: 2014-02-01
Clinical trial
Transplantation of Umbilical Cord Blood in Patients With Hematological Malignancies Using a Treosulfan Based Preparative RegimenStatus: Completed, Estimated PCD: 2021-12-14
Clinical trial
Hematopoietic Stem Cell Transplantation From Haploidentical Donors in Patients With Hematological Malignancies Using a Treosulfan-Based Preparative RegimenStatus: Recruiting, Estimated PCD: 2024-12-31
Clinical trial
A Scandinavian Controlled, Randomized, Open-label, and Multi-centre Study Evaluating if Once-daily Tacrolimus or Twice-daily Cyclosporin, Reduces the 3-year Incidence of Chronic Lung Allograft Dysfunction After Lung TransplantationStatus: Active (not recruiting), Estimated PCD: 2025-10-30
Clinical trial
Rituximab Plus Cyclosporine in Idiopathic Membranous NephropathyStatus: Recruiting, Estimated PCD: 2024-12-01
Clinical trial
A Multi-Center, Randomized Study of Cyclosporine or Corticosteroids as an Adjunct to Plasma Exchange in the Initial Therapy of Thrombotic Thrombocytopenic Purpura (TTP)Status: Completed, Estimated PCD: 2017-09-20
Clinical trial
A Phase II Randomized Controlled Trial Comparing GVHD-Reduction Strategies for Allogeneic Peripheral Blood Transplantation (PBSCT) for Patients With Acute Leukemia or Myelodysplastic Syndrome: Selective Depletion of CD45RA+ Naïve T Cells (TND) vs. Post-Transplantation Cyclophosphamide (PTCy)Status: Recruiting, Estimated PCD: 2026-12-31
Clinical trial
Abatacept for Graft Versus Host Disease Prophylaxis After Hematopoietic Stem Cell Transplantation for Pediatric Sickle Cell Disease: a Sickle Transplant Alliance for Research TrialStatus: Completed, Estimated PCD: 2021-12-30
Document
DailyMed Label: SandimmuneDocument
DailyMed Label: GengrafOrganization
AbbVie Inc.Document
DailyMed Label: NeoralOrganization
Novartis Pharmaceuticals Corporation